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Dermoscopy in General Dermatology
Published in Ashfaq A Marghoob, Ralph Braun, Natalia Jaimes, Atlas of Dermoscopy, 2023
Konstantinos Lallas, Zoe Apalla, Aimilios Lallas
The dermoscopic vascular pattern of psoriasis seems to remain unaltered irrespective of body site (scalp, palms, soles, folds, and genitalia) or clinical subtype (guttate or erythrodermic psoriasis).69 In contrast, there is variability in the amount and thickness of superficial scales according to the anatomic site. For example, scalp, palmar, and plantar lesions are often hyperkeratotic. Therefore, vessels might not be seen under dermoscopy unless the scales are mechanically removed. For scalp psoriasis, some additional clues have been described, including signet ring vessels, red loops, punctate hemorrhage, pigmentation (perifollicular, honeycomb pigment pattern), and white/yellow scales.8–11 In palmoplantar pustular psoriasis, dermoscopy might also reveal the underlying pustules in addition to the scales and vessels.6,7 Hyperkeratosis is usually absent in inverse psoriasis or psoriatic balanitis (Figure 12b.24), and thus, dermoscopy will reveal multiple regularly distributed dotted vessels without scales.70,71 A diffuse reddish background with dotted/glomerular vessels and white scales is the dermoscopic hallmark of erythrodermic psoriasis.69
Preliminary findings of altered functional connectivity of the default mode network linked to functional outcomes one year after pediatric traumatic brain injury
Published in Developmental Neurorehabilitation, 2018
Jaclyn A. Stephens, Cynthia F. Salorio, Anita D. Barber, Sarah R. Risen, Stewart H. Mostofsky, Stacy J. Suskauer
The TBI group included 11 participants (five females), 10 right-handed and 1 left-handed, whose mean age at testing was 16.0 years; range was 12.6–18.7 years. Six sustained mild and five sustained moderate TBI. Of the children with moderate TBI, two children had abnormal findings on initial computed tomography (CT) scans (one with punctate hemorrhage and one with hemorrhagic contusion), two had PTA between 24 hours and 7 days post-injury, and one had a GCS score of 12; see Table 1 for detail. Additionally, two children with normal CT scans had findings on magnetic resonance imaging (MRI) which was acquired at the first study visit (both with single punctate abnormalities which were felt to be nonspecific and not definitively related to trauma). There were no significant differences in connectivity values or behavioral performance between the participants with mild versus moderate TBI (all p values > 0.177).
Preparation, optimization, and in vivo evaluation of an inhaled solution of total saponins of Panax notoginseng and its protective effect against idiopathic pulmonary fibrosis
Published in Drug Delivery, 2020
Mengjiao Liu, Tianyi Zhang, Chen Zang, Xiaolan Cui, Jianliang Li, Guohua Wang
The lung surface of the sham-operation group was smooth, pink, and elastic (Figure 7(A)). Figure 7(B) shows that the lung surface of model group was uneven and dark red, the volume was reduced, the elasticity was poor, the hardness had increased, and the surface showed nodular changes. Changes of lung volume, color, and elasticity, are shown in Figure 7(C–E); these changes were mild, and the changes in lung volume, color, and elasticity, lay between the changes exhibited by the sham-operation group and the model group. Only a few lobes were dark red; these were scattered with a small amount of punctate hemorrhage and the lobes showed a slight reduction in volume (see Figure 7).
Superior sagittal sinus thrombosis as a rare complication of spontaneous intracranial hypotension syndrome: a case report and review of the literature
Published in International Journal of Neuroscience, 2019
Han Zhang, Xiaotian Zhang, Dongming Zheng
The patient was treated with a large amount of fluids (daily of 4000–5000 mL) to rehydrate and relieve the headache. When an orthostatic headache reoccurred after a sauna following non-contrast-enhanced brain MRI, the MRI demonstrated crescent-shaped hyperintense lesions on T1WI and T2WI of the bilateral frontoparietal lobes which were consistent with subdural effusions probably due to intracranial hypotension (Figure 1(C) and (D)). Midsagittal images revealed strip-type hyperintense lesions on T1 within the SSS (Figure 1(E)). The MRV scan showed that SSS was obliterated, and the left sigmoid sinus, transverse sinus, and jugular vein were narrower than the contralateral side which proved formation of SSST (Figure 2(B)). Considering that the symptoms of SIH have not achieved full remission, and combined with SSST, low molecular weight heparin (LMWH) (0.4 mL) was given immediately. However, 20 minutes after the first subcutaneous injection of LMWH, the patient developed a serious headache, nausea, and vomiting; he complained of numbness in mouth and both upper limbs without erythema. Neurological examination showed the patient to be alert and fully oriented with normal cranial nerve examination. LMWH was discontinued immediately, but by the time an urgent head CT that showed a subdural collection of fluid in bilateral frontoparietal lobes was performed, the CT value was near to CSF, and punctate T1 hyperintensities on the convex surface of the brain were observed, which are consistent with punctate hemorrhage. The density of the SSS was uneven with slightly hypointense lesions in the middle. The results of blood coagulation, serum ions were normal. We thought of the above discomfort symptoms as adverse drug reactions and, 2 hours later they improved by themselves. With rehydration treatment, the patient’s headache subsided gradually.