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Haematology and oncology
Published in Jagdish M. Gupta, John Beveridge, MCQs in Paediatrics, 2020
Jagdish M. Gupta, John Beveridge
9.22. Haemophilia A is associated withpetechiae.prolonged skin bleeding time (BT).prolonged prothrombin time (PT).prolonged activated partial thromboplastin time (APTT)haemarthrosis.
Liver Function Tests and Physiological Features of Liver Failure
Published in Peter Kam, Ian Power, Michael J. Cousins, Philip J. Siddal, Principles of Physiology for the Anaesthetist, 2020
Peter Kam, Ian Power, Michael J. Cousins, Philip J. Siddal
Prothrombin time (INR) is also a marker of the synthetic functions of the liver. It assesses the clotting factors involved in the extrinsic pathway of coagulation (factors II, V, VII, IX and X and fibrinogen) which are synthesized in the liver. As they have short half-lives, prothrombin time is a sensitive indicator of both acute and chronic liver disease.
Methods of nutritional assessment and surveillance
Published in Geoffrey P. Webb, Nutrition, 2019
Biochemical measures of nutrient status yield objective and quantitative measures and are the most sensitive indicators of nutritional status. They can usually be measured with great precision as is common with such analytical procedures. A number of these biochemical measures of nutrient status were discussed in the section dealing with the methods used to assess nutrient requirements e.g.: Measures of blood and tissue levels of nutrients or metabolites. Measures of nutrient excretion rates. Enzyme activation tests. Functional biochemical tests such as prothrombin time.
Nutritional deficiency presenting as acute pain, fatigue and bruising in a college health clinic
Published in Journal of American College Health, 2022
Adam Pallant, Tanya Sullivan, Andrew Kaluzny
Examination on follow-up 10 days after initial presentation is notable for a young man who now appears extremely fatigued with visible pallor. He is unable to stand fully upright due to pain in his joints, and demonstrates persistent mild flexion at both knees secondary to this pain (Figure 1). Vitals: temperature of 99.3, orthostasis with a supine pulse of 116 and a standing pulse of 140. Blood pressure remains stable and weight is unchanged. Physical exam is significant for markedly increased breadth and intensity of broad ecchymoses across the medial portion of bilateral thighs (Figure 2), and significant petechial hemorrhage on the lower extremities (Figure 3). Hemoglobin has dropped to 9.5 g/dl, and a mild lymphopenia is noted at 0.9 × 109/l with remainder of the differential normal. The platelet count remains normal at the 261 × 109/l. Total bilirubin has increased to 2.3 mg/dl (direct bilirubin of 0.4 mg/dl) with an elevated LDH of 240 IU/L. Prothrombin time is mildly elevated to 13.6 seconds (9.5-12.5) within normal INR of 1.2. ALT, AST, TIBC, and ferritin are normal.
Liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for determination of free and total dabigatran in human plasma and its application to a pharmacokinetic study
Published in Drug Development and Industrial Pharmacy, 2021
Khurshid Shaikh, Ashish Mungantiwar, Supriya Halde, Nancy Pandita
Healthy human male subjects aged between 18 and 45 years body mass index (BMI) range 18.50–30.00 kg/m2 with bodyweight ≥50 kg, having normal results for physical and medical examinations, vital signs, ECG, chest X-ray PA view, and laboratory tests during the screening and meeting the pre-defined inclusion criteria and none of the defined exclusion criteria were enrolled in the study. In order to prevent or avoid the possibility of bleeding; prior to investigation product administration, all subjects were evaluated for prothrombin time (PT), activated partial thromboplastin time (aPTT), and creatinine clearance (CrCl), and only the subjects with normal PT and aPTT, and the CrCl value >50 ml/min were dosed [21]. The study was conducted according to the ethical principles that have their origin in the Declaration of Helsinki and comply with the ICH GCP- E6 (R2) [26] and applicable national regulatory requirement(s).
Cottonmouth snake bites reported to the ToxIC North American snakebite registry 2013–2017
Published in Clinical Toxicology, 2020
K. Domanski, K. C. Kleinschmidt, S. Greene, A. M. Ruha, V. S. Bebarta, N. Onisko, S. Campleman, J. Brent, P. Wax
Our data demonstrate that cottonmouth envenomations cause primarily local effects and, occasionally, systemic toxicity. A previous poison center study reported edema in 53% and ecchymoses in 15% of cottonmouth envenomations [7]. These were the most common local effects seen in our study, but we found that they occur more frequently, with swelling in 100% and ecchymoses in 81% of patients. Prothrombin time prolongation occurred in 19% of patients in our study, which is higher than reported in a previous study [7]. Prothrombin times were recorded in 29 patients. Hypofibrinogenemia occurred in 3% of patients and emesis in 16%. These effects have not been described in prior studies. However, in an earlier report describing all snakebites reported in the NASBR from 2013 to 2015, including a subset of this population of cottonmouth envennomations, the percentages of these findings were higher [3].