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Specific Management of PPH
Published in Gowri Dorairajan, Management of Normal and High Risk Labour During Childbirth, 2022
The ratio usually followed in obstetrics is 1:1:1. That means for every four packed red blood cells transfused within 2 hours, equal units of fresh frozen plasma and platelets should be empirically transfused. Many hospitals follow the 3:2:2 ratio for obstetric haemorrhage due to the pregnancy-related changes in the coagulation system.
Septic shock
Published in Hung N. Winn, Frank A. Chervenak, Roberto Romero, Clinical Maternal-Fetal Medicine Online, 2021
Bryan E. Freeman, Michael R. Foley
After resolution of hypoperfusion, and in the absence of complicating factors such as myocardial infarction, acute hemorrhage, and so on, administration of blood products (not covered in recommendations for initial resuscitation) may be considered. Packed red blood cells should be transfused for hemoglobin levels <7.0 g/dL, with a target hemoglobin of 7.0 to 9.0 g/dL. The use of erythropoietin is not recommended in the treatment of severe sepsis unless there is another reason for its administration, such as renal failure (12).
Nucleated Cell Separation Using the Fenwal CS3000™
Published in Adrian P. Gee, BONE MARROW PROCESSING and PURGING, 2020
Herbert M. Cullis, Ellen Areman, Charles S. Carter
Packed red blood cells are in the PRBC bag and in the separation bag in the centrifuge. These cells can be siphoned into the PRBC bag. The PRBC bag can be aseptically removed from the system by sealing the lines. It can also be removed by withdrawing the needles from the rest of the set. Withdrawing the needles permits reconnection if necessary.
Capsaicin has potent anti-oxidative effects in vivo through a mechanism which is non-receptor mediated
Published in Archives of Physiology and Biochemistry, 2022
Ankita Chaudhary, Jalaj Kumar Gour, Syed Ibrahim Rizvi
After 21 days of capsaicin supplementation, the rats were sacrificed under light anesthesia and blood samples were collected into 10 U/ml heparinized syringes via cardiac puncture. Plasma was separated from erythrocytes by centrifugation of the collected blood at 800 g/4 °C/10 min and removal of the upper buffy coat and 15% of packed red blood cells (PRBCs). Subsequently, the RBCs were washed three times with ice-cold phosphate-buffered saline (PBS) (10 mM; pH 7.4) and utilized for the estimation of oxidative stress parameters; reduced glutathione (GSH), malondialdehyde (MDA), and plasma membrane redox system (PMRS). Plasma was stored at -80 °C (frozen) for the assessment of various other biochemical parameters; ferric reducing ability of plasma (FRAP), advanced oxidation protein products (AOPPs), and protein carbonyls (PCOs).
Fatal Sodium Nitrite Poisoning: Key Considerations for Prehospital Providers
Published in Prehospital Emergency Care, 2021
Matthew R. Neth, Jennifer S. Love, B. Zane Horowitz, Michael D. Shertz, Ritu Sahni, Mohamud R. Daya
The patient received multiple rounds of ACLS medications, including the administration of one milligram of epinephrine approximately every five minutes. Sodium bicarbonate and calcium chloride were administered due to concern for acidosis and hyperkalemia. Three doses of methylene blue, each at a dose of 2 mg/kg intravenously, were administered over five minutes approximately every 15 to 20 minutes. Additionally, two units of packed red blood cells were transfused in an attempt to expand the patient’s oxygen-carrying capacity by providing fresh red blood cells, as yet unaffected by methemoglobin. Bedside ultrasonography showed poor cardiac contractility without any palpable pulses during pulse checks. Despite about 70 minutes of CPR and ACLS measures in the ED, the patient never regained a pulse or signs of life, and resuscitative efforts were terminated.
Metformin protects red blood cells against rotenone induced oxidative stress and cytotoxicity
Published in Archives of Physiology and Biochemistry, 2021
Shambhoo Sharan Tripathi, Abhishek Kumar Singh, Farhan Akhtar, Ankita Chaudhary, Syed Ibrahim Rizvi
After 30 days of treatment, the rats were euthanised by standard protocol and blood samples were collected by cardiac puncture into heparinised syringes. The red blood cells and plasma were separated by centrifugation of the collected blood at 800 × g at 4 °C for 10 min, and subsequent removal of the upper buffy coat and 15% of packed red blood cells (PRBCs). Post-separation, the RBCs were washed thrice with ice-cold phosphate buffer saline (PBS) (10 mM; pH 7.4) and used for the assessment of oxidative stress parameters such as reduced glutathione (GSH), malondialdehyde (MDA), and plasma membrane redox system (PMRS). Plasma was frozen and stored at −80 °C for analysis of biochemical parameters such as the ferric reducing ability of plasma (FRAP), advanced oxidation protein products (AOPPs), and protein carbonyls (PCOs).