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The Pale Child
Published in Michael B O’Neill, Michelle Mary Mcevoy, Alf J Nicholson, Terence Stephenson, Stephanie Ryan, Diagnosing and Treating Common Problems in Paediatrics, 2017
Michael B O’Neill, Michelle Mary Mcevoy, Alf J Nicholson, Terence Stephenson, Stephanie Ryan
Looking at the FBC to assess iron-deficiency anaemia. Rationale: the FBC report should be assessed for the Mentzer index (MCV/number of red cells in millions). A Mentzer score <13 suggests thalassaemia.
Spectrum of β-Thalassemia and Other Hemoglobinopathies in the Saurashtra Region of Gujarat, India: Analysis of a Large Population Screening Program
Published in Hemoglobin, 2022
Nishith A. Vachhani, Daya J. Vekariya, Roshan B. Colah, Heena N. Kashiyani, Sanjeev L. Nandani
After generating awareness in the population of the region, a total of 16,780 individuals (including school and college students) were screened over a period of 1 year (from December 2017 to November 2018). Blood samples (2 mL), were collected in EDTA-containing vacutainers, after informed consent was obtained. Red blood cell (RBC) indices were measured on a semi-automated three-part hematology counter. The Mentzer index [3] was calculated using the formula [mean corpuscular volume (MCV)/RBC)]. A value of <13.000 was taken as a cutoff for suspected β-thal carriers [3]. The Shine and Lal index [4] was also calculated using the formula MCV × MCV × MCH (mean corpuscular Hb)/100. A value of <1530.00 was the cut off-for suspected β-thal carriers. Hb F, Hb A2 and other Hb variants were quantitated by automated cation exchange high performance liquid chromatography (HPLC) on the VARIANT II™ analyzer (Bio-Rad Laboratories K.K., Tokyo, Japan). A cutoff of Hb A2>3.5% was taken as a diagnostic level for β-thal trait. This study was approved by the Ethics Committee of the Institutional Review Board at Rajkot, Gujarat, India.
High Prevalence of Anemia and Inherited Hemoglobin Disorders in Tribal Populations of Madhya Pradesh State, India
Published in Hemoglobin, 2020
Sonam Chourasia, Ravindra Kumar, Mendi P.S.S. Singh, Chandrika Vishwakarma, Ashok K. Gupta, Rajasubramaniam Shanmugam
Low MCV (<76.0 fL) and MCH (<26.0 pg) values were observed in 63.0% (2456/3900) and 86.2% (3361/3900) of the cases. Forty-three (1.1%) subjects have high MCV (>100.0 fL) levels. Mentzer index (MI) and a red cell distribution width index (RDWI) was calculated in all cases and it was found that out of 3354 individuals who have low MCV and/or low MCH, 1401 (41.7%) had both MI >13 and RDWI >220, indicating a possible iron deficiency in these subjects. Furthermore, the presence of infection, as revealed by an abnormal leucocyte count, was observed in 466 (11.7%) cases. It was interesting to note that out of these 466 individuals, 270 (57.9%) likely also had an iron deficiency, indicating that subjects having iron deficiency are more prone to infections.