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Consumer Views on Health Issues Arising from Food Products
Published in Megh R. Goyal, Preeti Birwal, Santosh K. Mishra, Phytochemicals and Medicinal Plants in Food Design, 2022
Harita R. Desai, Murlidhar Meghwal
The indiscriminate use of antibiotics to livestock health is responsible for causing antibiotic resistance in humans. The use of synthetic hormones to increase the rate of growth in livestock has caused adverse effects on the naturally occurring levels of hormones in humans [69, 107].
A Functional Approach to Gynecologic Pain
Published in Sahar Swidan, Matthew Bennett, Advanced Therapeutics in Pain Medicine, 2020
As most painful ovarian cysts are physiologic, short-term watchful waiting is often the best option. The integrative clinician can play an important role in destigmatizing the ovarian cyst and explaining the normal physiology and helping the patient with short-term pain relief. The standard medical approach to recurrent physiologic cyst formation, and indeed most conditions associated with gynecologic pelvic pain, is in the form of hormonal contraception. Controlling the hypothalamic–pituitary axis and inhibiting ovulation will prevent the formation of most physiologic cysts. However, many integrative clinicians object to the use of the synthetic hormones in birth control.
Effects of Environmental Factors on the Endocrine System
Published in George H. Gass, Harold M. Kaplan, Handbook of Endocrinology, 2020
In recent years, there are more concerns about fertile or pregnant women in an environment associated with high reproductive and teratogenic risks. Although endocrine malfunctions resulting in reproductive failure are emphasized, other abnormal endocrine changes such as thyroid and adrenal malfunctions also affect the survival of individuals. Despite the apparent success of the reproductive process, deficiencies in these systems also lead to high mortality of the offspring. According to some recent studies, there are many risk factors, such as solvents, different types of pollution, anesthetic agents, and even video display terminals.32 Special attention is necessary in clinical uses of hormonally related drugs. They include synthetic hormones or hormonal extracts as well as their agonists and antagonists. Because they have profound effects on the endocrine system, the use of these drugs requires stringent screening tests. Toxicological testings with higher sensitivities are necessary.33
Dydrogesterone indications beyond menopausal hormone therapy: an evidence review and woman’s journey
Published in Gynecological Endocrinology, 2021
During their reproductive years many women suffer from various hormone-related medical conditions. If hormonal treatment is indicated, an increasing number of women prefer to receive bio-identical rather than synthetic hormones. However, bio-identical micronized progesterone is not always well tolerated due to its central nervous system effects. As a stereoisomer of progesterone, dydrogesterone does not display such effects and may be used as an optimal alternative. As the case study illustrates, dydrogesterone has multiple potential clinical uses throughout a woman’s reproductive years, from adolescence through to peri- and post-menopause. Apart from its indication as a component of menopausal hormone therapy, dydrogesterone can be used to treat a range of conditions affecting menses and pregnancy such as dysmenorrhea, irregular menstrual cycles, premenstrual syndrome, threatened or recurrent miscarriage, and luteal phase support during assisted reproduction. Evidence of benefit with dydrogesterone is particularly strong for the prevention of threatened or recurrent miscarriage.
Temperature regulation in women: Effects of the menstrual cycle
Published in Temperature, 2020
Fiona C. Baker, Felicia Siboza, Andrea Fuller
Combined oral contraceptives typically contain ethinyl estradiol and a synthetic progestin taken for 21 days, and a placebo taken for 7 days. There are also progestin-only contraceptives. Women taking oral contraceptives have low endogenous hormone levels but high levels of synthetic hormones [52]. As such, some effects observed in women taking oral contraceptives could reflect suppression of the endogenous hormones and/or effects of the exogenous hormones. Hormones contained in contraceptive preparations also are synthetic so may exert different effects to endogenous hormones. For example, ethinyl estradiol has a high affinity for estrogen (estradiol) receptors and is more potent [52] and may be bioactive for longer [51] than the endogenous hormone. They also may have different actions on progesterone/estrogen receptors as a consequence of differences in structure, type, and concentration, and are taken once per day as a single dose, whereas endogenous hormones are continuously secreted from the ovary in varying amounts across the menstrual cycle [51]. It should be noted that the assays used to measure endogenous progesterone and estrogen (typically estradiol) do not measure synthetic hormones and there is a large variation between individuals in the pharmacokinetics of contraceptive steroids [53].
Sheehan’s syndrome and sickle cell disease: the story of Natasha*
Published in Neuropsychological Rehabilitation, 2018
Barbara A. Wilson, Anita Rose, Gerhard Florschutz
Treatment for SS consists of hormone replacement such as ovarian, thyroid, and adrenocortical hormones. Synthetic hormones may be used. Oral contraceptives may be used to replace oestrogen/progesterone. There is a risk of diabetes insipidus and this is treated with yet another hormone. Growth hormone replacement therapy (GHRT) is sometimes used and has been shown to lead to increased muscle mass and an improved sense of well-being (Shivaprasad, 2011). Abs et al. (1999) conducted a study comprising 1034 adults with GH deficiency. SS was found to be the sixth most frequent aetiology and was responsible for 3.1% of cases. This contrasted with 53.9% of cases due to a pituitary tumour. There are a number of papers reporting on the treatment of SS with GHRT (for example, Abs et al., 1999; Diri et al., 2016; Kelestimur, et al., 2005; Shivaprasad, 2011). Abs et al. (1999) say that their work confirms earlier findings whereby untreated GH deficiency is associated with a number of clinical problems and that treatment is usually well tolerated. Kelestimur et al. (2005) found that treatment improved quality of life and body composition.