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Translational Research
Published in Goh Cheng Soon, Gerard Bodeker, Kishan Kariippanon, Healthy Ageing in Asia, 2022
Aging is related to a decline of gonadal hormone in both sexes: andropause in men and menopause in women. In men, reductions in testosterone can initiate a fall in bone mass, muscle mass, and physical function. In women, the effect of estradiol on bones is well known, but there is only some evidence regarding whether decline of estradiol adversely impacts muscle mass and physical function. Nevertheless, the lack of anabolic hormones has been demonstrated to predict health status and longevity in people of an older age. Thus, whether targeted HRT may have an effect in treating age-associated sarcopenia, cancer cachexia, and acute or chronic illnesses merits attention. HRT in women may prevent and reverse fall in bone mass, muscle mass, and physical function and perhaps enhance healthy aging and longevity (Horstman et al., 2012).
Managing Pain in the Presence of Autoimmune Disease
Published in Sahar Swidan, Matthew Bennett, Advanced Therapeutics in Pain Medicine, 2020
Approximately 94% of lead is sequestered in our bones and teeth.117 So, when menopause or andropause start to cause loss of bone density, the sequestered lead starts to flood into our system, disrupting many organ systems including negatively impacting the immune system and nervous system. Blood testing tends to greatly underestimate the toxic load someone is carrying.118 If lead can be found in significant levels in serum, you know someone is carrying a very high lead load. Thus, we can test negative for lead or other toxins in the blood and still have a big toxic load in fat and bone stores throughout the body.
The chemistry of the Body
Published in Gail S. Anderson, Biological Influences on Criminal Behavior, 2019
These drugs are not without side effects. All reduce testosterone levels, and because testosterone is a critical hormone in many functions, its loss can cause many health issues. Anti-androgen drugs are frequently used medically in conditions such as prostate cancer, so there are many studies available on the side effects. Anti-androgen drugs reduce bone density and lean body mass, both of which increase the risk of bone fractures. Other side effects include femininization, loss of body hair, and breast development.50 Anti-androgen drugs have also been associated with the development of diabetes and increased risk for metabolic syndrome and cardiovascular disease.51 They cause andropause, the male equivalent of menopause, which results in hot flashes and other unpleasant effects; it can cause depression and, perhaps most concerning, severe mood instability.49
Association between metabolic syndrome, hepatic steatosis, and testosterone deficiency: evidences from studies with men and rodents
Published in The Aging Male, 2020
Danielle Aparecida Munhos Hermoso, Paulo Francisco Veiga Bizerra, Rodrigo Polimeni Constantin, Emy Luiza Ishii-Iwamoto, Eduardo Hideo Gilglioni
Even though human life expectancy has increased in recent years, there are still incident health complications in the older population, some of which are related to age-decline in gonadal hormones. In women, the production of sex steroid hormones by the ovaries stops abruptly at approximately 50 years of age. Consequently, the serum estradiol (E2) level decreases rapidly, menstruation ceases, defining the menopause. Menopause is frequently accompanied by climacteric symptoms such as hot flushes, vaginal dryness, decreased libido, and mood swings [1]. In contrast to women, the reproductive function remains relatively intact in older men. Some of them, however, have similar symptoms to those of climacteric women, including hot flushes, decreased libido, erectile dysfunction (ED), tiredness, and decreased vigor [2]. As a slight decrease in testosterone (T) levels may be responsible for some of these symptoms, the term andropause was suggested for men. However, there is no precise definition for this term [3]. Not all older men have T deficiency and, thus, the analogy between andropause and menopause may belong to clinical manifestations, but not the nature of the hormonal changes [4]. Therefore, the widespread use of T replacement in men, in analogy to estrogen/progesterone replacement therapy in postmenopausal women, is questionable [3].
Andropause symptoms and sickness absence in Japanese male workers: a prospective study
Published in The Aging Male, 2020
Kumi Hirokawa, Yasuhito Fujii, Toshiyo Taniguchi, Jiro Takaki, Akizumi Tsutsumi
The andropause symptoms reported by middle-aged men include insomnia, decreased libido, reduced sexual activity, decreased mineral bone density, and abdominal obesity [28], and these are similar to menopausal symptoms in middle-aged women. Men with testosterone deficiency tend to display a similar syndrome, specifically in relation to the sexual domain, according to the European Male Aging Study survey [29,30]. Based on recommendations for clinical diagnosis [19], andropause refers to the combination of low testosterone levels and clinical symptoms, especially sexual symptoms. The tool used to measure andropause symptoms in the present study, the AMS scale, comprises not only “sexual symptoms,” but also “somatic” and “psychological” symptoms [31]. The results of this study were that sexual symptoms were not associated with sickness absence and neither were low testosterone levels. Additionally, no association was found between testosterone deficiency combined with high sexual symptoms and sickness absence. However, somatic symptoms were positively associated with an increased risk of sickness absence, particularly absences because of physical illness. Among the items in the AMS somatic symptom sub-scale was a question on “complaints in joints or muscles (pain in lower back, joints, or legs).” A higher percentage of men with testosterone deficiency reported back and/or neck pain than those without testosterone deficiency [32]. Somatic symptoms related to aging such as joint and muscle pain could be reflected on the scores of the AMS scale; however, those somatic symptoms are not specific for either andropause or LOH.
Effect of education about andropause health on level of the knowledge and attitude of men referring to the education and training retirement center of Shiraz
Published in The Aging Male, 2020
Maliheh Abootalebi, Fatemeh Vizeshfar, Naval Heydari, Farnoosh Azizi
The onset of hormonal changes in men occurs between 40 and 55 years of age, and about 70% of men in this age range experience symptoms of testosterone deficiency [4]. The most common symptoms include sexual dysfunction, decreased libido, general malaise, mood swings, cognitive impairment, irritability, performance difficulties, decline in enjoyment of life and general well-being, night sweats, sleep disturbances, and palpitations [5–9]. Men's health and health problems at different ages have received more attention in recent decades. Andropause has been recognized as a hidden threat to men's family life. Most men feel anxious about andropausal changes and do not know the cause. Some studies showed a link between the onset of symptoms of andropause and some psychological changes such as depression. Andropause and depression are associated with decreased male hormones [10]. Numerous studies worldwide have found that the symptoms of affective disorders are associated with hormonal changes and andropause. Middle-aged men and older might experience moodiness, irritability, nervousness, depression, aggravation, fatigability, poor concentration, and deteriorating memory. Mismanagement of stress and stress coping techniques lead some men to hate enjoyable activities and prolong the course of the above mentioned disorders [11]. One study showed that 21% of men aged 51–59 years, 26% of men aged 60–69 years, and 31% aged 70–86 did not have normal testosterone levels [12].