Adipsia

Adipsia

Fluid and electrolyte disorders

Published in Philip E. Harris, Pierre-Marc G. Bouloux, Endocrinology in Clinical Practice, 2014

Ploutarchos Tzoulis, Pierre-Marc G. Bouloux

Another cause of pure water deficit is adipsia, or impaired thirst. Patients with hypothalamic disease (e.g., tumors, radiotherapy, sarcoidosis) can have a defect in their hypothalamic osmoreceptors and associated hypodipsia or adipsia.

Vitamin D attenuated 6-OHDA-induced behavioural deficits, dopamine dysmetabolism, oxidative stress, and neuro-inflammation in mice

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Journal Information

Published in Nutritional Neuroscience, 2022

Adedamola Bayo-Olugbami, Abdulrazaq Bidemi Nafiu, Abdulbasit Amin, Olalekan Michael Ogundele, Charles C. Lee, Bamidele Victor Owoyele

6-OHDA lesions are commonly induced unilaterally, as bilateral dopamine denervation is associated with aphagia, adipsia, and weight loss [19]. Also, unilateral intrastriatal injections with 6-OHDA causes progressive loss of dopaminergic neurons, simulating nigrostriatal damage [20]. At different levels of the nigrostriatal tract, injection of 6-OHDA causes different degrees of DA degeneration [21] and these have different impacts behaviourally and histochemically. Striatal injection of 6-OHDA causes a graded and progressive loss of substantia nigra neurons [22], which is useful as a partial DA depletion model in studies of functional recovery [21]. It therefore mimics the earlier stage of the disorder [23].

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Fluid and electrolyte disorders

Vitamin D attenuated 6-OHDA-induced behavioural deficits, dopamine dysmetabolism, oxidative stress, and neuro-inflammation in mice