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Monographs of fragrance chemicals and extracts that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
A male patient, who had allergic contact dermatitis from oakmoss absolute in aftershave lotions, experienced exacerbations of his hand dermatitis when handling firewood or trees in the forest (presumably containing lichens), and he had allergic reactions to atranorin and evernic acid on patch testing (65). A woman was patch tested for pruritus vulvae. She strongly reacted to the FM I, oakmoss absolute, a cream and its perfume 1% pet., but the presence of oakmoss absolute in the perfume of the cream could not be ascertained (81).
Tetracaine
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
A 52-year-old woman with a 3-month’ history of pruritus vulvae had been repeatedly operated on because of urinary incontinence and frequently catheterized. She presented with erythematous scaly plaques on the vulva, perineal and perianal regions, and inner thighs. Patch tests were positive to an urological lubricant containing tetracaine, to the caine mix and to tetracaine HCI and negative to all topical medicaments previously used by the patient. She greatly improved when the lubricant was substituted. When, accidentally, a new nurse used the original lubricant again, the symptoms returned (32). Allergy to tetracaine in the same ointment caused allergic contact balanitis in a 41-year-old man, who had a urethral stenosis which was treated by periodic dilatations with a PVC dilator lubricated with the ointment (34).
Carcinoma of the Vagina and Vulva
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
Sadaf Ghaem-Maghami, Kostas Lathouras
Intraepithelial disease of the vulva often presents as pruritus vulvae, but 20%–45% are asymptomatic. These lesions are often raised above the surrounding skin, have a rough surface, and are variable in color: white, due to hyperkeratinization; red, due to immaturity of the epithelium; or dark brown, due to increased melanin deposition in the epithelial cells. However, the full extent of the abnormality is often not apparent until 5% acetic acid is applied. After 2 minutes, VIN turns white, and mosaic or punctation may be visible. All these changes are best examined colposcopically. Biopsies must be taken from abnormal areas. This can usually be done under local anesthesia in the outpatient.
Genitourinary syndrome of menopause in Chinese perimenopausal and postmenopausal women
Published in Climacteric, 2021
X. Ruan, L. Zhang, Y. Cui, M. Gu, A. O. Mueck
It has been reported that the incidence of older females suffering from vulvar pruritus and irritation was about 30% [32]. In contrast, in our study the prevalence of pruritus vulvae was 91.55%, of vulval burning was 86.67%, of vaginal burning sensation was 85.63%, and of vaginal pain and vulval pain was 85.48% and 85.26%, respectively (except for non-inflammatory causes). Despite the high frequency of these symptoms, more than 50% were mild, but this prevalence is still higher compared to other studies, which may be explained by the fact that the recruited women in our study came from all over the country to one specialized center. For most other studies, the women were recruited from various centers, often as multicenter trials.
Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription JieZe-1 in protecting against HSV-2 infection
Published in Pharmaceutical Biology, 2022
Tong Liu, Qingqing Shao, Wenjia Wang, Yonggui Ma, Tianli Liu, Ximing Jin, Jianguo Fang, Guangying Huang, Zhuo Chen
Drawing lessons from the traditional Chinese medicine, the Chinese herbal prescription JieZe-1 (JZ-1) was added and subtracted from Yihuang Decoction, an ancient prescription in Fu Qingzhu’s Obstetrics and Gynaecology during the Qing Dynasty period in China (Fu and Ou 2006). It consists of 10 Chinese medicinal herbs, namely, Phellodendron chinense C. K. Schneid. (Rutaceae), Ginkgo biloba L. (Ginkgoaceae), Solanum nigrum L. (Solanaceae), Taraxacum mongolicum Hand.-Mazz. (Asteraceae), Thlaspi arvense L. (Brassicaceae), Dictamnus dasycarpus Turcz. (Rutaceae), Smilax glabra Roxb. (Smilacaceae), Paeonia × suffruticosa Andrews (Paeoniaceae), Mentha canadensis L. (Lamiaceae), and Dryobalanops aromatica C. F. Gaertn. (Dipterocarpaceae). According to some studies, these herbs have anti-inflammatory, antibacterial, and antiviral biological activities (González-Castejón et al. 2012; Wang et al. 2017, 2020; Hua et al. 2018; Sun et al. 2019; Fang et al. 2020; Mahendran and Rahman 2020; Tong et al. 2020; Gong et al. 2021). As an in-hospital preparation of Tongji Hospital (Approval Number: Z20103135), JZ-1 is used for multiple infectious diseases of the lower genital tract. It is effective in treating pruritus vulvae, thermalgia, erosion, vaginal congestion, and excessive leucorrhoea clinically (Wei et al. 2007, 2008). In vivo and in vitro studies show that JZ-1 has a therapeutic effect on Trichomonas vaginitis (Chen et al. 2009a, 2009b), Candida albicans vaginitis (Chen et al. 2009c), and Ureaplasma urealyticum infection (Wei et al. 2007, 2008). It is also effective for GH and has no visible clinical adverse effects. In recent years, the research into anti-HSV effects of Chinese medicine has gradually advanced, from the focus on clinical efficacy to the study of the mechanism of its antiviral activity. The anti-HSV-2 effect of JZ-1 and the mechanism are worthy of being studied.
A multicenter, randomized, open, controlled trial to evaluate the efficacy of Honglilai Vaginal Cream and Premarin Vaginal Cream for Genitourinary Syndrome of Menopause in different subgroups of Chinese postmenopausal women
Published in Gynecological Endocrinology, 2022
Mukun Yang, Shouqing Lin, Shurong Zheng, Aijun Sun, Meilu Bian, Shilan Li, Jianli Liu, Lina Hu, Ning Hui, Jing Zhong, Hongchun Hou, Tianfu Yue, Xiaoli Gao, Wenpei Bai
The incidence of adverse events was lower in the Honglilai group (43.6%) than in the Premarin group (58%), the difference was statistically significant (χ2 = 6.874, p = .009). The main adverse events including swollen breasts, pruritus vulvae, abdominal pain, and vaginal bleeding. All the above symptoms were relieved after drug withdrawal. No serious adverse events occurred.