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Foot and ankle radiology
Published in Maneesh Bhatia, Essentials of Foot and Ankle Surgery, 2021
Plantar fibromatosis is a benign yet locally invasive neoplasm involving the plantar fascia. There is abnormal proliferation of the fibrous tissue, which replaces the plantar aponeurosis and can slowly invade adjacent skin and deep musculature (8). It is associated with other fibroproliferative conditions such as Dupuytren and Peyronie diseases, although flexion deformity is not a common finding (9). On US, plantar fibromatosis demonstrates low or mixed echogenic discrete, nodular thickening along the plantar fascia. MRI is the modality of choice in assessing plantar fibromatosis. As with US, there is nodular thickening along the plantar fascia, which is low or intermediate SI on T1- and T2-weighted images due to the acellular, fibrous nature of the lesions (Figure 22.12).
The locomotor system
Published in C. Simon Herrington, Muir's Textbook of Pathology, 2020
Palmar fibromatosis (Dupuytren's contracture) begins as a firm nodule in the palm of middle-aged and elderly patients and in time extends to form subcutaneous bands, which produce flexion contractures, especially of the fourth and fifth fingers. Histologically, the palmar aponeurosis is expanded by multiple nodules of proliferating myofibroblasts. In time these nodules become heavily collagenized and poorly cellular. Similar lesions may occur in the sole of the foot, usually without contracture (plantar fibromatosis) or in the penis (Peyronie's disease).
Hands
Published in Tor Wo Chiu, Stone’s Plastic Surgery Facts, 2018
Other areas of involvement: Garrod’s knuckle pads (PIPJ) occur in ~20% of patients, lying between skin and extensor tendon, attached to paratenon.Plantar fibromatosis (Lederhosen) but no flexion contracture.Penile curvature (Peyronie).Frozen shoulder.The first two rarely cause symptoms.
Use of calcium channel blockers in dermatology: a narrative review
Published in Expert Review of Clinical Pharmacology, 2021
Yang Lo, Lian-Yu Lin, Tsen-Fang Tsai
Verapamil is one of the conservative treatment choice for plantar fibromatosis [35], possibly through the property of enhanced secretion of MMP1 in fibroblasts and collagenase secretion [36]. Several articles reported its efficacy for Peyronie’s disease [37,38], 57% plaque volume decreased after intralesional verapamil injection [38], and lesion size and penis curvature decreased 30% after intralesional verapamil for a total of 6 weeks (10 mg/cm2, every 2 weeks) [39]. However, some studies reported no significant improvement after intralesional verapamil or nicardipine [40,41]. Treatment success was reported after topical verapamil 15% gel was applied twice daily for 9 months, which decreased the size in Peyronie’s to 85% [37]. However, another study suggested that topical verapamil is not recommended for the treatment for Peyronie’s disease, due to its inability to infiltrate the tunica albuginea [42]. Whether topical verapamil is effective for treatment of Peyronie’s disease is still controversial.
A post hoc analysis of Dupuytren contracture treated with collagenase Clostridium histolyticum across disease stages
Published in Journal of Plastic Surgery and Hand Surgery, 2018
Gary M. Pess, Maj Sundbom, Koo Wilson, Daniel Lindqvist, Lars B. Dahlin
Dupuytren disease (OMIM 126900) is a benign fibroproliferative progressive disorder, affecting the palmar fascia of the hands and fingers, and is characterized by flexion contracture within the joints of the fingers. The prevalence varies between populations and age groups and the disease is more common among men and in people of Northern European descent [1–3]. The disease is heterogeneous involving both genetic and environmental factors [4,5]. The onset and progression varies and occasionally other fibroproliferative conditions, such as Peyronie disease (OMIM 171000) and plantar fibromatosis (or Ledderhose disease), are associated with Dupuytren contracture.