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Benign Neoplasms
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Abdullah Demirbaş, Ömer Faruk Elmas, Necmettin Akdeniz
Examples of histologic variants include the following: Acanthotic type: This is the most common histologic pattern. Characteristically, there can be hyperkeratosis, papillomatosis, pseudo-horn cysts, and hyperpigmentation.Hyperkeratotic type: This has prominent papillomatosis, orthohyperkeratosis, mild acanthosis, and cyst-like structures. There is no hyperpigmentation.Clonal type: This is characterized by the localized proliferation and clonal expansion of basaloid cells.Adenoid type: This demonstrates anastomoses from basaloid epidermal cells to the epidermis. Horn and pseudo-horn cysts are not seen; however, hyperpigmentation is common.Irritated/inflamed type: Lichenoid inflammation is observed. It can be confused with squamous cell carcinoma in some cases. Acantholysis, dyskeratosis, and spongiosis can be seen.
Acute erythematous rash on the trunk and limbs
Published in Richard Ashton, Barbara Leppard, Differential Diagnosis in Dermatology, 2021
Richard Ashton, Barbara Leppard
A rash which looks like lichen planus (although usually atypical) can rarely be due to a drug. The rash has the typical mauve hue of lichen planus but the lesions are larger and more confluent. Histology shows lichenoid features. Drugs which can cause it include: Beta blockersChlorpropamideGoldMethyl dopaQuinineChloroquineEthambutolMepacrinePenicillamineThiazides
Psoriasis and lichen planus
Published in Rashmi Sarkar, Anupam Das, Sumit Sethi, Concise Dermatology, 2021
Lichen planus (Greek leichen, ‘tree moss’; Latin planus,‘flat’) is an inflammatory disease affecting skin, mucosa (Figure 9.15), scalp, and nails. The term ‘lichenoid’ refers to the histologic description of inflammatory infiltrate and basal cell liquefaction and used to characterize the pathology of diseases resembling lichen planus. This is the only papulosquamous disorder that presents itself without scales.
Lichenoid lesions of the upper labial mucosa: a systematic review and a report of a new case with extensive follow-up
Published in Acta Odontologica Scandinavica, 2023
The first description of lichenoid tissue reaction (LTR), from 1973, characterizes it as a cascade of histological events that leads to epidermal basal cell damage and clinical presentation of lichen-like changes in the skin and mucosa [1]. Lichenoid tissue reaction (or interface dermatitis) is seen in diverse mucocutaneous disorders, such as lichen planus (LP), lupus erythematosus and graft-versus-host disease (GVHD) [2]. Of these, LP is considered the prototypic and most common, with global prevalence of 0.2–1% [3,4]. A chronic inflammatory disorder with unknown aetiology [5], LP can also affect the oral mucosa [6,7]. Typically, oral lichen planus (OLP) presents as bilateral reticular buccal lesions in a middle-aged female patient. In addition to reticular type, the clinical forms of OLP include atrophic, erosive, papular, plaque and bullous. Frequently, these forms appear in combination [6,7].
A drug safety evaluation of mogamulizumab for the treatment of cutaneous T-Cell lymphoma
Published in Expert Opinion on Drug Safety, 2019
Salma Afifi, Sara Mohamed, Jennifer Zhao, Francine Foss
Cutaneous drug eruptions were associated with mogamulizumab, occurring in 24% of patients, compared to only one patient (1%) in the vorinostat arm [8]. These rashes commonly appear papular or maculopapular, morbilliform, or erythematous (Figure 2). Rashes may sometimes appear as lichenoid, spongiotic or granulomatous dermatitis. Other more rare presentations include plaques, pustular eruptions, and folliculitis [21]. Most cases were grade 1–2 and treated with topical steroids. In the clinical trial, systemic steroids were not allowed to be used for the treatment of rash. However, systemic steroids are not a contraindication during mogamulizumab treatment and may be considered in clinical practice for the treatment of rash when appropriate. Drug rashes were the most common reason leading to treatment discontinuation (7%). Signs and symptoms of progression to Steven–Johnson syndrome and toxic epidermal necrosis should be monitored carefully.
Lichen sclerosus of the oral mucosa: clinical and histopathological findings. Review of the literature and a case report
Published in Acta Odontologica Scandinavica, 2018
Anna-Maija Matela, Jaana Hagström, Hellevi Ruokonen
The lichenoid lesion clinically and histopathologically resembles lichen planus. This lesion usually appears as reticular, atrophic or ulcerative forms. The manifestation is often asymmetrical, as in oral LS. Anamnestic data is important, as a lichenoid reaction is often caused by medication, dental restorative materials or may be a graft-versus-host reaction in a bone marrow transplantation patient. White lesions situated in contact with amalgam restoration suggest a lichenoid reaction. Histopathologically, lichenoid reactions have the same features as lichen planus, but the lymphocyte infiltrate may consist of eosinophils and is situated deeper in the lamina propria [39].