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Papulosquamous Diseases
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Melek Aslan Kayıran, Jordan V. Wang, Ayşe Serap Karadağ
Guttate psoriasis is more common in children and young adults. Lesions are in the form of multiple, small, erythematous, scaly plaques that are 0.5–1.5 cm in diameter. Streptococcal throat infection is believed to precede many cases. A relationship has been found with HLA-CW*0602.
Psoriasis: Clinical Spectrum
Published in Siba P. Raychaudhuri, Smriti K. Raychaudhuri, Debasis Bagchi, Psoriasis and Psoriatic Arthritis, 2017
Chelsea Ma, Smriti K. Raychaudhuri, Emanual Maverakis, Siba P. Raychaudhuri
Guttate psoriasis is characterized by acute onset of multiple discrete small papules of <1 cm over the trunk and extremities, often in a centripetal fashion. The characteristic morphologic appearance is monomorphic droplet-like papules (gutta) that are at the same stage of evolution (Figure 8.2a). Guttate psoriasis can affect children and adolescents after an upper respiratory tract infection or streptococcal infection [34,35]. Generally, the disease is self-limiting, but it can sometimes progress to chronic plaque psoriasis [34]. Even patients who have complete recovery from an episode of guttate psoriasis have a significantly greater risk of developing plaque psoriasis in the future [36]. Thus, it is not surprising that guttate psoriasis and chronic plaque psoriasis are genetically similar, both with strong associations with the PSORS1 genetic locus [37,38].
Plaque-type psoriasis—chronic plaque, guttate, and erythrodermic phenotypes
Published in M. Alan Menter, Caitriona Ryan, Psoriasis, 2017
Guttate psoriasis is a distinctive form of psoriasis that characteristically occurs in children and young adults. It may arise on its own (acute guttate psoriasis) or may complicate existing, often quite limited, chronic plaque psoriasis (guttate flare of chronic plaque psoriasis). Typically, guttate plaques erupt explosively over large areas of the skin surface 1–2 weeks after an episode of acute tonsillitis or pharyngitis.23
Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics for the treatment of psoriasis
Published in Expert Opinion on Drug Delivery, 2021
Based on clinical manifestations, psoriasis can be categorized into five types, namely, psoriasis vulgaris, inverse, guttate, erythrodermic, and pustular psoriasis. Usually, a patient is affected by only one particular type at a time. The treatment regime depends on the criticality of the disease and varies among patients [5]. Out of all the different types, psoriasis vulgaris occurs in majority of the cases. In this type, reddish round or oval plaques are found in the joint region like knees and elbows [6]. Inverse psoriasis is also known as flexural psoriasis and occurs in folded regions of the body like armpits, genitals, breasts, etc. Nearly 18% of psoriatic patients suffer from this type [7]. Guttate psoriasis generally starts from childhood and occurs due to bacterial infection. Here, tiny droplet-like sores appear on arms, scalp, and legs [8]. Erythrodermic psoriasis is an inflammatory form of this disease that forms scales and redness to most of the body parts. Some patients experience tachycardia, shading of scales and sudden change in body temperature [9]. The last type, pustular psoriasis, is usually seen as pustules on the skin of feet or hands. Very few psoriatic patients are affected by this type [10]. Psoriatic patients also suffer from other morbidities. They have high risks of depression and metabolic complications. Additionally, it has been observed that around 30% of psoriatic patients suffer from psoriatic arthritis [11,12].
Oxidative stress and inflammatory response in patients with psoriasis; is there any relationship with psychiatric comorbidity and cognitive functions?
Published in Psychiatry and Clinical Psychopharmacology, 2019
Erdem Deveci, Tuba Kocacenk, Ebru Şahan, Onur Yılmaz, Ahmet Öztürk, İsmet Kırpınar
The course of the disease, particularly plaque psoriasis, is chronic with periodic remissions of variable duration occasionally lasting years (without therapy). Guttate psoriasis can become chronic and take on the features of chronic plaque psoriasis or in some cases resolve with treatment of the inciting infection, only to recur again in the future with precipitating events. The primary form of generalized and localized pustular psoriasis is also chronic, with periodic remissions. Secondary forms of pustular psoriasis, in the setting of plaque psoriasis, may be transient or may put on a new morphology after conversion. This may be seen as well in erythrodermic psoriasis (differentiated from generalized plaque psoriasis); it may be transient (weeks, months, or a few years) in duration or chronic (less often) [4].
A review of antibiotics and psoriasis: induction, exacerbation, and amelioration
Published in Expert Review of Clinical Pharmacology, 2019
Rifampin is often combined with other antibiotics to treat leprosy, tuberculosis, and mycobacterium avium complex infections. It kills bacteria by inhibiting DNA-dependent RNA polymerase. In dermatology, rifampin is also famous for the treatment of hidradenitis suppurativa, folliculitis decalvans, and dissecting cellulitis based on both of bacterial suppression and anti-inflammatory ability. Plaque psoriasis: a randomized controlled trial (n = 50) for plaque-type psoriasis was performed by Dogra L et al. with rifampin 10mg/kg for 36 weeks in the active treatment arm. PASI score reduced significantly in rifampin group compared with placebo (Mean PASI change = 88% vs 1.2%) [37].Guttate psoriasis: Tsankov N et al. conducted two controlled trials (n = 92 and 87) for guttate psoriasis. Rifampicin 600 mg per day for 60 days were given in experimental groups. The results showed significant PASI response and lower body surface area involvement in treatment groups compared with placebo, while there was no difference between streptococcal carriers or not [38,39].Mixed: Tsankov N et al. also performed a single-arm study for mixed type psoriasis including erythrodermic, pustular, and plaque type with at least 60% body surface area involvement. Rifampicin 600mg/day for 30–45 days were administered, and six out of 10 recipients improved moderately to completely [40].