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Collision Tumors and Exceptions to Rules
Published in Ashfaq A Marghoob, Ralph Braun, Natalia Jaimes, Atlas of Dermoscopy, 2023
Andrea Combalia, Xavier Fustà, Alicia Barreiro, Cristina Carrera
Additional clues to help differentiate DFs from skin cancer include:Palpation. DFs reveal a positive “dimple sign,” which consists of a central depression when the lesion is pressed along its margin.The peripheral network in DFs is fine, light brown, and often associated with ring-like globules, which are located toward the center of the lesion between the delicate network and the central scarlike area.
Benign tumors
Published in Rashmi Sarkar, Anupam Das, Sumit Sethi, Concise Dermatology, 2021
They are firm or hard intracutaneous nodules. They are usually found on the limbs as solitary lesions, but sometimes two or three or even more are found in the same patient. Generally, they are brownish in color (from the haemosiderin pigment) and have a rough or warty surface because these dermal nodules have the propensity to thicken up the epidermis immediately above them. On squeezing the overlying epidermis, the ‘dimple sign or Fitzpatrick sign’ is seen, due to tethering of the overlying epidermis to the underlying lesion (Figure 12.4). Multiple dermatofibromas are associated with systemic lupus erythematosus, chronic myeloid leukemia, HIV, and patients on immunosuppressive therapy.
Lumps and lesions
Published in Manu Shah, Ariyaratne de Silva, The Male Genitalia, 2018
Manu Shah, Ariyaratne de Silva
These common benign lesions are often found in the pubic area or on the thighs. They are relatively rare on the genitals themselves. Mostly they are asymptomatic but occasionally they may itch or become tender. Most lesions present in early adulthood as isolated dermal nodules measuring 5–10mm in diameter. The diagnosis is made clinically. The overlying skin is usually pigmented and when the nodule is laterally compressed it exhibits a characteristic ‘dimple’ sign due to tethering of the lesion to the overlying epidermis.
Diagnosis and Treatment of 75 Patients with Idiopathic Lobular Granulomatous Mastitis
Published in Journal of Investigative Surgery, 2019
Breast mass was the most common symptom, occurring in 89.3% (67/75) patients. Other symptoms included skin swelling (2.7%, 2/75), breast pain (2.7%, 2/75) and nipple discharge (5.3%, 4/75). Before they visited doctors, 32% (24/75) of patients experienced a rapid increase in breast mass, 12% (9/75) experienced skin ulceration, 2.7% (2/75) had nipple bleeding and 6.7% (5/75) had nipple discharge within 9 to 60 days (median 30 days). Moreover, 41.3% (31/75) received antibiotics before admission, in which 25.8% (8/31) patients had reduction in lumps and skin redness, but antibiotics treatment was ineffective in 74.2% (23/31) of patients (Table 2). Physical examination showed unilateral mass in 73 patients (left, 62.7%, 47/75; right, 34.7%, 26/75) and bilateral mass in two patients. Furthermore, 92% (69/75) had single lesion, 5.3% (4/75) two lesions and 2 cases had three lesions. Lesions were located in the areola area in 15 patients. The proportion of the mass in the peripheral area of the breast was higher than that in the areola area. The mass size by palpation was 1.5 cm × 1.0 cm ∼9.0 cm × 8.0 cm, with a mean size of (3.90 ± 2.05) cm × (4.83 ± 2.44) cm. Among these patients, 10 patients (13.3%) showed palpable axillary lymph nodes. Twenty-one cases (28%) had ipsilateral nipple retraction, 3 cases (4%) had pelvic surface skin edema, 3 cases (4%) had sinus formation, 1 case (1.3%) had the dimple sign and 18 cases (24%) had acute inflammation (Table 3).