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Dermatologic diseases and pregnancy
Published in Hung N. Winn, Frank A. Chervenak, Roberto Romero, Clinical Maternal-Fetal Medicine Online, 2021
Holly Edmonds, Dana Ward, Ann G. Martin, Susana Leal-Khouri
Hemangiomas, hemangioendotheliomas, glomangiomas, glomus tumors, neurofibromas, dermatofibromas, and leiomyomas may arise during gestation. Except for neurofibromas, these tumors tend to regress postpartum, but may recur during subsequent pregnancies. Keloids may grow rapidly and desmoid tumors may also develop during pregnancy. Desmoid tumors should be treated by wide local excision if there is rapid enlargement and resultant local tissue destruction.
Laparoscopic Subtotal/Total/Proctocolectomy
Published in Haribhakti Sanjiv, Laparoscopic Colorectal Surgery, 2020
In general, the preferred operation depends on the severity and distribution of colorectal adenomas. Other important factors to consider include the risk of desmoid tumors and the patient's age and comorbidities. The specific APC genotype may be useful in predicting which patients would be better suited for ileorectal anastomosis (IRA) versus total proctocolectomy with IPAA, by predicting the severity of colorectal polyposis and the risk of desmoid development [13]. IPAA is more extensive surgery compared to IRA and is associated with an increased risk of bleeding and reduction in fertility in women. Patients with an IRA who subsequently develop severe rectal polyposis will require a secondary proctectomy.
Soft Tissue Sarcomas
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
Thomas F. DeLaney, David C. Harmon, Karol Sikora, Francis J. Hornicek
The etiology of desmoid tumors is unknown. However, the identification of clonal chromosomal changes in a significant fraction of cases supports the neoplastic nature of these tumors, and emerging evidence implicates dysregulated wound healing in the pathogenesis of these and other fibroblastic lesions.
Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments
Published in International Journal of Hyperthermia, 2021
Robb Merrill, Henrik Odéen, Christopher Dillon, Rachelle Bitton, Pejman Ghanouni, Allison Payne
As with any aspect of MRgFUS treatments, acoustic coupling of the ultrasound beam to the patient is critical. The addition of the skin-cooling pad assembly to the acoustic window requires careful attention to ensure complete acoustic coupling is achieved with no air bubbles. In the pig experiments, successful acoustic coupling required the skin-cooling pad assembly to be covered with water, as shown in Figure 4(b). The conformable nature and feedback pressure control allow for the pad to be used at a variety of treatment sites under variable load conditions, as shown in Figure 7. This flexibility is required for treatment of desmoid tumors. The skin-cooling pad assembly was able to maintain pressure and conform to the desired anatomy with the pressure control system. The only pressure problem encounter occurred when the system operational pressure set-point was set below the baseline back-pressure and flow resistance of the assembly (including tubing lines, skin-cooling pad assembly and valves). It was found that a set-point value of approximately 115 mbar (at 1300 meters elevation) counteracted this potential problem and allowed pad coupling and conformability to be maintained throughout the study.
Combination therapy with sorafenib and celecoxib for pediatric patients with desmoid tumor
Published in Pediatric Hematology and Oncology, 2020
Joanna Robles, Vahakn S. Keskinyan, Matthew Thompson, Joseph T. Davis, David Van Mater
Desmoid tumors, also known as aggressive fibromatosis, are local tumors of mesenchymal origin that may cause significant morbidity due to their infiltrative nature.1,2 Risk factors for the development of desmoid tumors include familial adenomatous polyposis, pregnancy, blunt trauma, previous surgery, and oral contraceptive medications.3 Desmoid tumors can develop in any anatomic location, but they are most commonly found in the extremities, trunk, abdominal wall, and intra-abdominal cavity. The behavior and clinical presentation of these tumors depends on their size, location, and degree of infiltration. While many patients are asymptomatic, the mass effect of the tumor may lead to pain, discomfort, paresthesia, neuropathy, and decreased joint mobility.2,4
Sino-orbital desmoid tumor in a pediatric patient – Case report with review of literature
Published in Orbit, 2019
Mariel Angelou Parulan, Gangadhara Sundar, Yew Kwang Ong, Tseng Tsai Yeo, Victor Lee, Miriam Santiago Kimpo
Desmoid tumor is also known as aggressive fibromatosis, desmoid fibromatosis, musculo-aponeurotic fibromatosis, or deep fibromatosis.4 Typically noted in the abdominal areas, it occurs less frequently in the head and neck (12–15%).5,6 A review of head and neck desmoids in pediatric patients reported that majority are located in the mandible, submandibular area, neck, and tongue.6 A few of the reported cases presenting as a pediatric orbital mass included a 5-year-old boy who presented with painless right eyelid swelling with ptosis and proptosis, a 10-month-old boy with unilateral orbital mass extending to the lateral orbital wall, maxillary sinus, and temporal and infratemporal fossa, and a 3-year-old girl with unilateral ptosis and upper lid fullness. The first case was treated with combination chemotherapy and the latter two were subjected to complete excisions, with orbital exenteration for the second case. All cases reported no recurrences.7–9 Although histologically known to be benign, DT is known to have an aggressive and unpredictable behavior and thus may behave like malignant tumors.5,10 It can grow into massive sizes in the head and paranasal regions, capable of causing bony destruction. A proper assessment and accurate diagnosis is necessary before planning its definitive management.