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Adverse drug reactions on the skin
Published in Robert A. Norman, Geriatric Dermatology, 2020
Bullous and vesicular drug eruptions are diseases in which blisters and vesicles occur as a complication of the administration of drugs. Blisters are a well-known manifestation of cutaneous reactions to drugs. In many types of drug reaction bullae and vesicles may be found in addition to other manifestations. Bullae are usually noted in erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, fixed eruptions when very intense, urticaria, vasculitis, porphyria cutanea tarda and phototoxic reactions (from furosemide and nalidixic acid). Tense, thick-walled bullae can be seen in bromoderma and iododerma as well as in barbiturate overdosage.
Descriptions of important reactions
Published in Jerome Z. Litt, Neil H. Shear, Litt's Drug Eruption & Reaction Manual, 2017
In many types of drug reactions, bullae and vesicles may be found in addition to other manifestations. Bullae are usually noted in: erythema multiforme; Stevens–Johnson syndrome; toxic epidermal necrolysis; fixed eruptions when very intense; urticaria; vasculitis; porphyria cutanea tarda; and phototoxic reactions (from furosemide and nalidixic acid). Tense, thick-walled bullae can be seen in bromoderma and iododerma as well as in barbiturate overdosage.
Descriptions of Important Reactions
Published in Jerome Z. Litt, Neil H. Shear, Litt's Drug Eruption & Reaction Manual, 2017
In many types of drug reactions, bullae and vesicles may be found in addition to other manifestations. Bullae are usually noted in: erythema multiforme; Stevens–Johnson syndrome; toxic epidermal necrolysis; fixed eruptions when very intense; urticaria; vasculitis; porphyria cutanea tarda; and phototoxic reactions (from furosemide and nalidixic acid). Tense, thickwalled bullae can be seen in bromoderma and iododerma as well as in barbiturate overdosage.
Pharmacokinetics and pharmacodynamics of dextromethorphan: clinical and forensic aspects
Published in Drug Metabolism Reviews, 2020
Ana Rita Silva, Ricardo Jorge Dinis-Oliveira
Since DXM can be found in the form of a bromide salt, bromide poisoning may occur if large quantities are taken. Bromide poisoning, known as bromism, is primarily a chronic neuropsychiatric disorder manifested by behavior changes, headaches, apathy, irritation, slurred speech, psychosis, tremors, ataxia, hallucinations, and coma (James et al. 1997; Frances et al. 2003; Hsieh et al. 2007). It can also cause weight loss and bromoderma characterized as an acneiform rash mimicking a pyoderma gangrenosum (Kunze 1976; Battin and Varkey 1982; Hung 2003; Maffeis et al. 2008; Oda et al. 2016).