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Prostatic Hypertrophy/Benign Prostatic Hypertrophy (BPH)
Published in Charles Theisler, Adjuvant Medical Care, 2023
Stinging Nettles (Urtica dioica): There is some limited evidence that Urtica dioica (600 mg bid) may improve some symptoms of BPH, including lower urinary tract symptoms. There is also evidence that Urtica dioica and saw palmetto (Serenoa repens) as in PRO 160/120 may be efficacious for lower urinary tract symptoms associated with BPH. In one RCT, researchers gave individuals either stinging nettles or a placebo for eight weeks. They found a significant reduction in symptoms for people taking stinging nettles, but not those taking the placebo.14 In three other clinical trials on BPH patients, Urtica dioica, or nettle, had a better impact in reducing patients' clinical symptoms than a placebo. The results of another study showed that simultaneous consumption of higher doses of U. dioica, up to 7 gm/day, plus the medication prazosin (Minipress), compared with the consumption of prazosin alone, resulted in significant improvements in the clinical symptoms of BPH.15,16,17
Science Behind Maca: A Traditional Crop from the Central Andes
Published in Raj K. Keservani, Anil K. Sharma, Rajesh K. Kesharwani, Nutraceuticals and Dietary Supplements, 2020
Gustavo F. Gonzales, Cinthya Vasquez-Velasquez, Dulce Esperanza Alarcón-Yaquetto
One of the most studied herbal extracts to treat BPH is Serenoa repens or saw palmetto, used in traditional medicine by Native Americans, demonstrating a favorable activity against LUTS and cystitis (Buck, 2004). Commercially it is known as Permixon, and it contains compounds such as long-chain fatty acids, phytosterols such as stigmasterol, β-sitosterol, and campesterol (Buck, 2004), which inhibit isoenzymes 5-α reductase (Van Coppenolle et al., 2000); they also inhibit the binding of DHT with RA (Nicholson and Ricke, 2011), which confers antiapoptotic and antiproliferative effects (Van Coppenolle et al., 2000).
Benign prostatic hyperplasia
Published in J Kellogg Parsons, E James Wright, The Brady Urology Manual, 2019
Serenoa repens (saw palmetto): Some data suggest clinical effectiveness in men with BPHMechanism of action unknown, but is associated histologically with induction of atrophy and epithelial contractionSaw palmetto alone does not generally affect PSA concentration; however, some ingredients in combination therapies may possess anti-androgenic activity that could potentially decrease PSACommon dose for BPH is 320 mg (lipophilic ingredients) daily.
A review of the treatment of male pattern hair loss
Published in Expert Opinion on Pharmacotherapy, 2020
Katherine York, Nekma Meah, Bevin Bhoyrul, Rodney Sinclair
Serenoa Repens/Saw Palmetto is a type of palm. Extract from its berries results in competitive non selective inhibition of 5AR type I and II and less DHT uptake by the hair follicle. It also has the additional function of estrogen receptor activation which aids anagen maintenance and catagen normalization.[62] It has demonstrated efficacy in BPH[63] but few studies exist to support its efficacy in androgenetic alopecia. In a small randomized double blind placebo controlled pilot study of 10 males with AGA on oral SR, improvement was seen in 60%[62]. An open label study comparing the efficacy of finasteride 1mg to oral SR after 24 months found 38% of patients receiving SR had increased hair growth, whilst 68% of those on finasteride showed improvement.[17]In another small study, SR extract in a lotion and shampoo base were applied for three months by 34 men and 28 women, resulting in a 35% increase in hair density[64].
The influence of nutritional factors on prostate cancer incidence and aggressiveness
Published in The Aging Male, 2018
Manrique Pascual-Geler, Noelia Urquiza-Salvat, Jose Manuel Cozar, Inmaculada Robles-Fernandez, Ana Rivas, Luis Javier Martinez-Gonzalez, Francisco Manuel Ocaña-Peinado, Jose Antonio Lorente, Maria Jesus Alvarez-Cubero
In other cancer like breast cancer, the consumption of fruits and vegetables, dietary fiber intake, vitamin supplementation along with the intake of probiotic products, are the most extensively studied by a negative association to cancer risk [13]. In PCa it is clear that obesity and metabolic syndrome are important risk factors [3,4]. Based on the epidemiological studies, several dietary factors and vitamins/supplements may be associated with PCa risk and/or progression of disease [14]. Many nutrients show potential benefits in helping to slow progression and reduce recurrence, as well as complementing conventional treatment to improve quality of life [15]. Nutraceuticals and supplements, particularly antioxidants, polyphenols and soy have evidence for benefit for prevention of PCa and progression of the disease [3]. Comhaire and Mahmoud [16] suggest food supplementation with the liposterolic extract of Serenoa repens and a combination of the antioxidants selenium, lycopene and natural vitamin E, together with fish oil to prevent or delay PCa and benign prostatis hypertrophy. Trends in the published data suggest that consumption of carbohydrates, saturated, trans and ω-6 fats and certain vitamin supplements may promote PCa risk and progression [17] . Conversely, consumption of fruit, vegetables, dietary fiber and ω-3 fatty acids seem to slow the risk and progression of the disease [18], even to produce a small reduction in prostate cancer risk [19].
Over-the-counter medication availability could augment self-management of male lower urinary tract symptoms
Published in Postgraduate Medicine, 2018
Claus G. Roehrborn, Martin M. Miner, Richard Sadovsky
It should be noted that effective blinding of herbal therapies such as Serenoa repens is difficult due to the odor of the extract. However, in one of the few studies using an effective blinding approach, gelcaps containing the extract or placebo were blister packaged and the effectiveness of blinding was tested at the end of the study by asking participants to guess the treatment assigned. This double-blind, randomized, controlled study, the Complementary and Alternative Medicine for Urinary Symptoms (CAMUS) trial, definitively showed that over a study duration of 72 weeks, increasing doses of Serenoa repens did not reduce the rate of LUTS more than that of placebo [80].