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Concept of the Traditional Medicinal System and Holistic Health
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
The presence of TCM can be traced by means of inscribed pieces of literature as far back as around 3,000 years. One of the primaeval texts on the subject of traditional Chinese medicine is the Yellow Emperor's manual of medicine or Ti Nei Ching. Traditional Chinese medicine is based upon the holistic management approach and an acceptance of the body's ability to come back to its balanced health states, provided the appropriate motivation to do so. The two most significant energies of the body that are required to be in balance are negative (yin) and positive (yang). Both of these forces oppose each other and rule the entire universe. Management is thus carried out by keeping in mind the source of the imbalance which demonstrates itself in symptoms, as compared to addressing merely the symptoms of disease largely and abandoning the cause without correction. It takes into consideration that the human body has a self-healing mechanism, and any intervention should only be made to enhance its self-healing capabilities. The physician at that time had to depend upon the examination of the body surface, the colour of the body's waste product (urine, sputum or faeces), body temperature and pulse (Ellis, 1994).
Connective Tissue Disorders
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Laura Atzori, Caterina Ferreli, Franco Rongioletti
Course: Disease activity typically continues for 3–6 years, but some patients develop longer periods of activity or recurrences. Self-healing is possible. Tissue sclerosis may cause joint contractures and other functional impairments.
Bio-Implants Derived from Biocompatible and Biodegradable Biopolymeric Materials
Published in P. Mereena Luke, K. R. Dhanya, Didier Rouxel, Nandakumar Kalarikkal, Sabu Thomas, Advanced Studies in Experimental and Clinical Medicine, 2021
Self-healing is known as the human body repairs the damaged tissues by itself whenever there is an injury. This happens when the portion of the injury is smaller in size. When there is an injury or damage which is beyond self-healing, there is an introduction of alternative material like the use of an implant. Implants may be subjected to various loads; wear and aging which causes failure and needed to replace. Researchers are trying to produce materials that can heal or repair by itself the first types of self-healing biomaterials are composites that irreversibly repaired. Second generation self-healing materials can reversibly restore the damaged matrix. To get improved mechanical and physical properties polymeric self-healing materials, nanoparticles are used. Compared to metals and ceramics, polymers show lower strength and modulus which can be improved by various techniques.
Polysaccharides from Laminaria japonica protect memory abilities and neurogenesis in mice after cranial irradiation through ameliorating neuroinflammation and collagen IV degradation
Published in International Journal of Radiation Biology, 2022
Siqin Zhang, Shaoyong Chen, Pian Ao, Rong Cai, Wenqi Liu, Li Wei
As is commonly known, learning and memory abilities are closely related to adult neurogenesis (Cameron and Glover 2015). Therefore, the regulation of adult neurogenesis can enhance and improve cognitive function. DCX and Ki67 are common markers for newborn and immature neuron in the study of adult neurogenesis (Rao and Shetty 2004; Moon et al. 2016). In this study, the RIBI model has been successfully established in Kunming mice strain, confirmed by our MWM data. Radiation has proven to result in neurogenesis impairment in the mice brain, evidenced by the significantly reduced densities of DCX and Ki67-positive cells in the irradiated animals. Our results once again confirmed conclusion of published study that neural stem cells or progenitor cells (NSCs/NPCs) are sensitive to radiation (Zanni et al. 2015; Wang et al. 2019). The adult brain is originally capable of self-repair through neurogenesis of the hippocampus when engaging in noxious stimulus. Unfortunately, such ability of self-healing is usually temporary because of the inhibition by the deterioration and disruption of neurogenic microenvironment or niches (Thored et al. 2006). Here, we found LJP could preserve neurogenesis injury in the RIBI mice, proved by the markedly increased densities of DCX and Ki67-positive cells in the irradiated mice with LJP treatment.
PCR detection of Mycobacterium ulcerans—significance for clinical practice and epidemiology
Published in Expert Review of Molecular Diagnostics, 2018
Gisela Bretzel, Marcus Beissner
BU involves the skin and the subcutaneous adipose tissue. The disease starts as a painless papule, nodule, plaque, or edema that usually evolves into large painless ulcerations with characteristically undermined edges, often accompanied by edema of the surrounding skin. About 5–10% of patients have multifocal lesions and/or osteomyelitis. Bones may be affected by direct spread from an overlying cutaneous lesion or through lymphohematogenous dissemination from remote lesions, bone involvement may however also occur in patients with no evidence of past or present lesions. Lesions are classified into three categories (I: single lesions, <5 cm diameter; II: single lesions 5–15 cm diameter; III: single lesions >15 cm diameter, multiple lesions, lesions at critical sites, osteomyelitis) [1,2,4,5,12]. Self-healing processes may lead to scarring and contractures. Though mortality is low, morbidity and subsequent functional disability are severe [1,2,5,13–15].
Recent development and biomedical applications of self-healing hydrogels
Published in Expert Opinion on Drug Delivery, 2018
Yinan Wang, Christian K. Adokoh, Ravin Narain
Self-healing is one of the most fundamental properties of living tissues that allows them to withstand repeated damage [1]. Healing in biological systems is accomplished by the vascular networks that supplies biochemical components, such as Von Willebrand factor, at injured site, forms reversible self-healing polymer–colloid aggregates, releases Factor VIII, and clotting by converting fibrinogen to fibrin fibers. Inspired by this process, White and coworkers have developed microcapsule-based systems that release healing agents in response to environmental stimulus at damage site [2–5]. Unfortunately, some challenges, such as limited self-healing cycles as well as the potential interference on the materials properties due to the addition of fillers, still need to be addressed before the materials could be used as human implants.