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Cardiovascular Risk Factors
Published in Nicole M. Farmer, Andres Victor Ardisson Korat, Cooking for Health and Disease Prevention, 2022
Cookware may also be a factor in preventing loss of minerals such as potassium. Water-free cooking using muti-ply cookware that allows for water-free cooking was assessed in comparison with traditional cookware in a study of 57 participants by Mori et al. (2012). Biomarkers of 24-hour urinary potassium and vitamin C were used to determine vegetable intake. Participants in the cookware experimental group were provided vegetables daily for 2 weeks and instructed to consume 350 g of vegetables daily. Photographs of food during cooking, serving plates, and post eating were provided to research staff. Participants in the water-free cookware group had significantly higher potassium levels after 2 weeks compared to their baseline and compared to the traditional cookware group and control group.
African Medicinal Plants and Traditional Medical Knowledge
Published in Charles Wambebe, African Indigenous Medical Knowledge and Human Health, 2018
Gerard Bodeker, Emma Weisbord, Drissa Diallo, Robert Byamukama, Yahaya Sekagya, Charlotte I.E.A. van't Klooster
During the 1990s, Uganda was one of the first countries in Africa to engage THPs in combating HIV transmission and also in evaluating traditional herbal remedies used to manage AIDS-related conditions. Other research has focused on malaria and also on a range of common illnesses. In this report, as part of the EU-funded Multi-University Initiative on Traditional Healthcare (MUTHI) Makerere University collaborated with Mbarara University in Southwest Uganda and an association of THPs, PROMETRA Uganda, to create a legal framework to partner in investigating important traditional medicines for scientific evaluation.
Understanding medications and medical investigations
Published in Ross Balchin, Rudi Coetzer, Christian Salas, Jan Webster, Addressing Brain Injury in Under-Resourced Settings, 2017
Ross Balchin, Rudi Coetzer, Christian Salas, Jan Webster
Muti is a general term (derived from the Zulu word for tree) that collectively refers to the various medicines used in traditional medicine in Southern Africa. Such medicines are prepared by traditional healers to treat a wide range of illnesses and complaints. They can be made from plants, various animal parts or minerals.
miR-23a-3p-abundant small extracellular vesicles released from Gelma/nanoclay hydrogel for cartilage regeneration
Published in Journal of Extracellular Vesicles, 2020
Hongxing Hu, Lanlan Dong, Ziheng Bu, Yifan Shen, Jian Luo, Hang Zhang, Shichang Zhao, Fang Lv, Zhongtang Liu
hUC-MSCs morphology observed under the microscope revealed a spindle-like shape (Figure 1(a)). To evaluate the muti-lineage differentiation potential of hUC-MSCs, they were induced to chondrogenic, adipogenic, osteogenic cells when cultured in chondrogenic, adipogenic, osteogenic induction medium, respectively. The images from Alcian blue, Oil Red O, Alizarin Red staining (Supplementary Figure 1) indicated that hUC-MSCs showed muti-lineage differentiation. Moreover, we measured the surface marker of hUC-MSCs such as CD44, CD73, CD151, CD34, CD133 by flow cytometer assay (Figure 1(b)). The analysis data confirmed that hUC-MSCs were consistent with the criteria for identifying stem cells. Furthermore, we successfully isolated sEVs from hUC-MSCs and identified the characteristics using various experiments (Figure 1(c–e)). hUC-MSCs-sEVs exhibited a spherical microvesicle structure observed under the TEM, whose diameters were approximately from 50 to 150 nm (Figure 1(c)). Data from NTA demonstrated that the average diameters of the microvesicles were about 142.9 nm, while the percentage of the vesicles with diameters 30–150 nm was 99.2% and the concentration was 8.2 × 106 particles/mL (Figure 1(d)). In addition, western blot analysis revealed that the exosomal surface marker CD81, CD63, CD9 expressed on sEVs rather than hUC-MSCs (Figure 1(e)). In general, all these results confirmed sEVs were successfully isolated from hUC-MSCs.
Dissecting the molecular landscape of pancreatic cancer: towards a precision medicine approach
Published in Expert Review of Precision Medicine and Drug Development, 2019
Antonio Pea, Liang Cheng, Claudio Luchini
In 2011, a French group of research demonstrated a significant improvement in overall survival (more than 4 months in average) for PDAC patients treated with a combination of 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) than those treated with gemcitabine alone [4,5]. Notably, Von Hoff and colleagues described a significant improved in overall survival (about 2 months) for PDAC patients treated with gemcitabine and the stromal-targeting nanoparticle albumin-bound paclitaxel (nab-paclitaxel) than those treated with gemcitabine alone [5,6]. Although such muti-drugs oncological treatments have improved the survival of PDAC patients, the control of disease and its progression remains still challenging. Therefore, alternative therapeutic approaches are needed to improve clinical outcomes.
Revision of potential prognostic markers of cholangiocarcinoma for clinical practice
Published in Expert Review of Anticancer Therapy, 2023
Charupong Saengboonmee, Sumalee Obchoei, Kanlayanee Sawanyawisuth, Sopit Wongkham
The emergence of the ‘Omics’ technologies, exosome extraction, and bioinformatics facilitate the biomarker discovery in many cancers, including CCA. Although there are several novel biomarkers reported for CCA in the past 5 years (Table 1), none of them is officially approved for use in clinical practice. A vast cohort with appropriate control groups for validation is still needed. The international wide with a muti-centers collaborative program to establish the potential prognostic markers for CCA should be conducted. In addition, several research translating the preclinical data to routine laboratory service should be encouraged to facilitate and transfer the potential biomarkers from preclinical studies to clinical practice.