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Anti-Hyperglycemic Property Of Medicinal Plants
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Karanpreet Singh Bhatia, Arpita Roy, Navneeta Bhardavaj
Juniperus communis, commonly known as juniper berry, is a member of Cupressaceae family, and widely grown in North America, Asia, and Europe. It is a small coniferous plant or shrub and has anti-hyperglycemic and anti-hyperlipidemic potential. Sánchez de Medina et al. (1994) reported that juniper decoction at a dosage of 0.25 g/kg, significantly decreased glucose levels in normoglycemic rats and a dosage of 125 mg/kg was efficient for STZ-I hyperglycemic rats. They suggested that the hypoglycemic effect of juniper can be due to either an increase in peripheral glucose consumption or a potentiation of glucose-induced insulin secretion (Sánchez et al., 1994). Methanolic extract of juniper has been evaluated against type 2 diabetes in streptozotocin nicotinamide induced (STZN-I) hyperglycemic rats. A significant reduction in blood glucose level along with different lipid profile parameters was reported (Banerjee et al., 2013).
Monographs of essential oils that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
The common juniper (Juniperus communis L.) is an aromatic and evergreen coniferous shrub or tree. It is widely distributed in Europe, North Africa, North America and north Asia southwards to the Himalayas. It produces blue-black ‘berries’, which are not true berries in the botanical sense, but are the female seed cones which have a berrylike appearance. The junipers are grown commercially in several countries, including the United States, Canada, northern Italy, and Croatia. Juniper berries are widely used in the food industry as flavorings (in tea, beer, brandy and marinades for meat, poultry and fish) and in the production of juniper-flavored spirits, such as gin (8).
Role of Natural Agents in the Management of Diabetes
Published in Rohit Dutt, Anil K. Sharma, Raj K. Keservani, Vandana Garg, Promising Drug Molecules of Natural Origin, 2020
Monika Elżbieta Jach, Anna Serefko
Juniperus communis is a coniferous plant whose bark is commonly used in traditional and folk medicine, especially in the Northern Hemisphere, for management of diabetes. Besides bark, its aerial parts, berries, and fruits are widely used for alleviation of various complaints (Bais et al., 2014; Banerjee et al., 2013). Juniper contains various active compounds including flavonoids, volatile oil, coumarins, and several labdane diterpenes and diterpenoids (Bais et al., 2014).
Medicinal plants consumption against urinary tract infections: a narrative review of the current evidence
Published in Expert Review of Anti-infective Therapy, 2021
Efthymios Poulios, Georgios K. Vasios, Evmorfia Psara, Constantinos Giaginis
Ebani and coworkers investigated the antimicrobial activity of EOs obtained from star anise, basil, origanum, clary sage and thymus against MDR strains of Escherichia coli, Enterococcus spp., Candida albicans, and Candida famata, previously isolated from dogs and cats suffering from UTIs. Thymus and origanum EOs showed the greatest activity against all the examined pathogens; thus, they may be suggested for external and/or intravesical washes formulation in small animals [39]. In a similar study, Lagha and coworkers assessed the antibacterial potential of five medicinal plant EOs against UTIs induced by E. coli using disc diffusion and other minimal inhibition concentration (MIC) assays. Moreover, EOs biofilm inhibitory activity was evaluated by crystal violet. Gas chromatography-mass spectrometry (GC-MS) methodology found a variability amongst EOs, concerning compound composition and their quantity. Antibacterial properties were found only in cases of Origanum majorana, Thymus zygis and Rosmarinus officinalis. In contrast, Juniperus communis and Zingiber officinale did not exert any effect against E. coli. Further, T. zygis EO exerted the greatest antibacterial action against E. coli, followed by O. majorana and R. officinalis. Additionally, EOs exerted enhanced biofilm inhibitory action, and especially R. officinalis EO exhibited the greatest antibiofilm activity followed by T. zygis and O. majorana [40].
Hesperidin-loaded nanoemulsions improve cytotoxicity, induce apoptosis, and downregulate miR-21 and miR-155 expression in MCF-7
Published in Journal of Microencapsulation, 2021
Judie Magura, Daniel Hassan, Roshila Moodley, Irene Mackraj
Induction of apoptosis and regulation of cell cycle progression or cell cycle arrest (stopping in-phase until DNA is repaired or cells undergo apoptosis) are regarded as practical approaches in cancer treatment (Murad et al. 2016, Jaudan et al. 2018). In keeping with this approach, Li et al. (2018) demonstrate a dichloromethane fraction from the roots of Toddalia asiatica (L.) Lam. (TA) induced cell cycle arrest at G2/M phase and apoptosis in HT-29 cells and could be a promising source for colon cancer therapeutics. Similarly, extracts from Juniperus communis showed natural therapeutic effects against oesophagal cancer through induction of cell cycle arrest and apoptosis in ESCC cells (Li et al. 2021).