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The twentieth century
Published in Michael J. O’Dowd, The History of Medications for Women, 2020
Hydrastis canadensis ‘This drug, commonly known as golden seal, has a direct action on the vaso-motor nerves and is therefore useful in cases of subinvolution, interstitial fibroids, and all forms of uterine congestion.’
Treatment with a Variety of Herbal Agents
Published in Ethan Russo, Handbook of Psychotropic Herbs, 2015
Subsequently, the patient underwent a gastrointestinal regimen, advised by a clinical nutritionist, comprised of a two-month course of goldenseal (Hydrastis canadensis) in conjuction with butyric acid, quercetin, and gamma-oryzanol. A marked reduction in gastrointestinal symptoms and food tolerance resulted, along with a mild improvement in “sense of well-being.” Headaches continued intermittently but were controllable with 1,100 mg of ginger powder, as needed, or, rarely, anti-inflammatories or triptan preparations (sumatriptan nasal [Imitrex] or rizatriptan oral [Maxalt-MLT]).
Hydrastis canadensis (Goldenseal) and Lawsonia inermis (Henna)
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Md. Mizanur Rahaman, William N. Setzer, Javad Sharifi-Rad, Muhammad Torequl Islam
Medicinal plants have been used worldwide for thousands of years as alternative or complementary medicines. They contain natural substances that are valuable due to their biological activities. These plants are promising sources of chemical components that can used for drug development and synthesis. However, a few medicinal plants are considered due to their nutrition, and as a result of that, these plants (e.g., ginger, green tea, and walnuts) are recommended for their therapeutic values (Hassan, 2012). Most people who turn each year to medicinal plants do so because they believe these plant remedies will cause fewer or no undesirable side effects (Philomena, 2011). However, medicinal herbs are important as a primary health care mode for approximately 85% of the world's total population (Pesic, 2015) and also an important resource for drug discovery; approximately 80% of all synthetic drugs are derivedfrom them (Bauer and Bronstrup, 2014). Both Hydrastis canadensis (goldenseal) and Lawsonia inermis (henna) are well known medicinal herbs due to their high physiological activities. Hydrastis canadensis,commonly known as “goldenseal”, is broadly used for its important therapeutic activitiesin humans, such as antimicrobial, anti-inflammatory, anti-spasmodic, anti-parasitic, anticancer, and anti-secretory activities. Additionally, it is sometimes used for the treatment of digestive disorders, nasal congestion, snakebite, chronic candidiasis, canker sores, and vaginitis (Asmi and Lakshmi, 2013). On the other hand, pharmacological studies have shown that henna shows different activities, such as antibacterial, anti-parasitic, antifungal, antioxidant, molluscicidal, antipyretic, immunomodulatory, hepatoprotective, antidiabetic, analgesic, anti-inflammatory, central nervous, wound and burn healing, hypolipidemic, anti-urolithiatic, anti-diarrheal, antiulcer, diuretic, anticancer, and also some other pharmacological effects (Al-Snafi et al.,2019).
Bioactivation of herbal constituents: mechanisms and toxicological relevance
Published in Drug Metabolism Reviews, 2019
Goldenseal extracts (Hydrastis canadensis) is a popular dietary supplement in the United States for gastrointestinal disorders. The primary bioactive constituents are the MDP-containing isoquinoline alkaloids including hydrastine and berberine. Concomitant administration of goldenseal extract inhibited the metabolism of CYP2D6 and CYP3A4 index substrate drugs in healthy subjects (Gurley et al. 2008a, 2008b). Ingestion of a goldenseal supplement (1.3 g root extract containing 132 mg hydrastine and 77 mg berberine) for 2 weeks led to 62% and 41% increase in AUC and Cmax of midazolam respectively (Gurley et al. 2008b). Hydrastine was shown to be a mechanism-based inhibitor of CYP3A4, with inactivation parameters KI = 110 µM and kinact = 0.23 min−1 (Chatterjee and Franklin 2003). The quasi-irreversible inhibition was evidenced by time- and NADPH-dependent formation of the 455 nm absorbing species, with no dissociation of the MI complex in the presence of selective CYP substrates. Mechanism-based inactivation of CYP3A4 and CYP2D6 by berberine was also demonstrated (Zhao et al. 2015). While a carbene may be involved in the MI complex formation, the catechol formed via oxidative demethylenation of the MDP moiety was identified in healthy subjects after oral administration of a goldenseal supplement (Gupta et al. 2015).
Cancer Related to Herbs and Dietary Supplements: Online Table of Case Reports. Part 5 of 5
Published in Journal of Dietary Supplements, 2018
Native Americans used goldenseal (Hydrastis Canadensis L.) as a medicinal remedy and yellow coloring agent (IARC, 2016). It is used to treat gastric infections causing diarrhea and as a topical ointment on skin infections. Oral preparations range from 100 to 470 mg daily. Rat studies suggest an increased risk of liver cancer. After their review, the International Agency for Research on Cancer (IARC, 2016) concluded: “There is sufficient evidence in experimental animals for the carcinogenicity of goldenseal root powder” (Goldenseal, p. 86).“There is inadequate evidence in humans for the carcinogenicity of goldenseal” (Goldenseal, p. 86).“Goldenseal root powder is possibly carcinogenic to humans (Group 2B)” (Goldenseal, p. 86).
Green Fabrication of silver nanoparticles by leaf extract of Byttneria Herbacea Roxb and their promising therapeutic applications and its interesting insightful observations in oral cancer
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2023
Gunashekar Kalvakunta Subramanyam, Susmila Aparna Gaddam, Venkata Subbaiah Kotakadi, Hema Gunti, Sashikiran Palithya, Josthna Penchalaneni, Varadarajulu Naidu Challagundla
The BH-AgNPs detected have substantial cell inhibition, the study was conducted by selecting the IC50 concentrations of 89.25 µL/mL, against the KB cell lines and evaluated Cell Cycle study results by Flow Cytometry. The cells treated with Std Control and BH-AgNPs with a concentration of 89.25 µL/mL. The results revealed follows: the % of Cells get arrested in the different stages of their life cycle. In Sub G0/G1 phase (Apoptotic phase), 1%, 0.66% and 0.62% of cells get arrested in Untreated, Standard and BH AgNPs respectively. In G0/G1 phase (Growth Phase), 69.70%, 52.65% and 58.77% of cells get arrested in Untreated, Standard and BH AgNPs respectively. In S phase (synthetic phase), 4.85%, 11.36% and 9.17% of cells get arrested in Untreated, Standard and BH-AgNPs respectively. On the other hand, in G2/M phase, 22.78%, 30.18% and 27.38% of cells get arrested in Untreated, Standard and BH-AgNPs respectively. BH-AgNPs exhibit prominent Cell Cycle phase arrest similar to the std Control, Camptothecin on KB cells. Figure 7(a,b,c). In the present study also the BH-AgNPs showed cell cycle arrest at G2/M stage which leads to induced cell death, thus proves to BH-AgNPs as effective anticancer agents against oral cancer cells. A report on Nepeta deflersiana extract-mediated AgNPs also showed that the cell cycle and apoptosis were induced by SubG1 arrest and lead to apoptotic/necrotic cell death in HeLA cells [52]. Similar type of results were observed by AgNPs biosynthesized by Hydrastis canadensis and Thuja occidentalis induce differential cytotoxicity through G2/M arrest in A375 cells [54]. Our earlier leaf extract of Argyeria nervosa also showed cell cycle arrest at the G2/M stage, further leads to induced cell death [10]. The present study concludes that BH-AgNPs was confirmed to be a competent anticancer agent against KB oral cancer cells.