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Herbal and Supplement Use in Pain Management
Published in Sahar Swidan, Matthew Bennett, Advanced Therapeutics in Pain Medicine, 2020
Dosing: Back pain: Doloteffin, ardeypharm 2400 mg taken in three divided doses daily for up to 1 year has been used.12WS 1531 600–1200mg of harpagophytum extract twice daily for 4 weeks.13Osteoarthritis: 670–800 mg three times daily up to 2 months.(Doloteffin, ardeypharm) 2400 mg taken in three divided doses daily for up to 1 year has been used.12
African Traditional Medicine
Published in Charles Wambebe, African Indigenous Medical Knowledge and Human Health, 2018
Contrary to the widespread belief that African traditional medicine is mystic, superstitious, and demonic rather than scientific, some evidence suggests that the practitioners were probably aware of the natural causes of illness (Oke, 1995; Erinosho, 1998, 2005, 2006). For example, in sub-Saharan Africa, the ancient kingdoms and empires of Asante, Benin, Borno, Ethiopia, Jukun, Monomotapa and Mali, Nubia, Nri, Nupe, Oyo, and Songhai had remarkably codified healing recipes (Mungwini, 2009), which prominently featured medicinal plants as key components. Indeed, the folkloric claims of a number of these plants have been scientifically validated, possible evidence that they were used not only for their spiritual and symbolic significance, but also for their perceived “pharmacological” effects. Notable among these plants include Acacia senega (Gum Arabic), Agathosma betulina (Buchu), Aloe ferox (Cape Aloes), Aloe vera (North African Aloes), Artemisia afra (African wormwood), Boswellia sacra (Frankincense), Commiphora myrrha (Myrrh), Harpagophytum procumbens (Devil's Claw), Hibiscus sabdariffa (Hibiscus, Roselle), Hypoxis hemerocallidea (African potato), Prunus africana (African Cherry), and Catharanthus roseus (Rosy Periwinkle) (Sofowora 1993; Hostettmann et al., 2000).
The important role of fungi in inflammatory bowel diseases
Published in Scandinavian Journal of Gastroenterology, 2021
Sui Wang, Yu-Rong Zhang, Yan-Bo Yu
Modulation of the fungal community has been demonstrated to offer therapeutic approaches for IBD. Fluconazole is mostly used to eradicate fungal infections, usually candidiasis or candidaemia infections, in immunocompromised IBD patients. Fluconazole-treated patients who were confirmed to have fungal overgrowth showed that the UC activity index decreased significantly compared with that of other patients treated with mesalazine (mesalamine), azathioprine, or probiotic lacidofil [100]. Increasing the protective function of yeast probiotic strains or inhibiting C. albicans infections may be a potential therapeutic strategy. For instance, specifically targeting Enterobacteriaceae with antifungal drugs can help treat IBD patients with overgrowth of C. albicans [29,33]. Some studies claim that the water extract of Harpagophytum procumbens has an antioxidant and anti-inflammatory profile and significantly inhibits C. albicans and C. tropicalis in IBD patients. In addition, similar protective effects have been shown in hemp inflorescence water extracts, alcoholic Phlomis fruticosa, O. sipyleum extracts, and Ocimum americanum extracts and Phlomis herba-venti extracts in IBD models [101–105] based on small case reports or studies.
Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine in Pain Reduction and Functional Capacity in Osteoarthritis Patients
Published in Journal of Dietary Supplements, 2019
Jordi Puigdellivol, Carme Comellas Berenger, Miguel Ángel Pérez Fernández, Juan M. Cowalinsky Millán, Christian Carreras Vidal, Inés Gil Gil, Julio Martínez Pagán, Borja Ruiz Nieto, Francisco Jiménez Gómez, Francesc X. Comas Figuerola, María E. Aguilar Hernández
Clinical trials have shown that CS and GS are effective and safe drugs for pain control and functional improvement in patients with mild to moderate OA of the knee (Michel et al., 2005; Kahan, Uebelhart, De Vathaire, Delmas, & Reginster, 2009; Hochberg, 2010; Lee, Woo, Choi, Ji, & Song, 2010). In addition, the combination of these two compounds could have a positive synergistic effect on the various affected structures of the joint (Canapp, McLaughlin, Hoskinson, Roush, & Butine, 1999; McCarty, Russell, & Seed, 2000; Tat et al., 2007; Calamia et al., 2010). In the present study, CS and GS have been linked with other components as a food supplement (Artipotect®). Other ingredients include hydrolyzed collagen and devil's claw (Harpagophytum procumbens) and bamboo (Bambusa arundinasa) extracts. Hydrolyzed collagen has been shown to improve joint function and be effective in managing OA-associated symptoms (Schauss, Stenehjem, Park, Endres, & Clewell, 2012). Devil's claw contains harpagoside, a monoterpenoid specific of devil's claw and responsible for the anti-inflammatory activity attributed to this plant. Several studies have shown the beneficial effects of harpagoside in OA and other inflammatory diseases (Chrubasik, Conradt, & Roufogalis, 2004; Oltean et al., 2014). Harpagoside suppresses IL-6 expression in primary human OA chondrocytes, leading to a significant anti-inflammatory effect (Haseeb, Ansari, & Haqqi, 2017). Bamboo extract is a rich source of organic silica (>70%) and traditionally has been considered useful in strengthening the musculoskeletal system.
Effects and mechanisms of natural plant active compounds for the treatment of osteoclast-mediated bone destructive diseases
Published in Journal of Drug Targeting, 2022
Qiang Xu, Zhiyou Cao, JiaQiang Xu, Min Dai, Bin Zhang, Qi Lai, Xuqiang Liu
Harpagoside, a glycoside isolated from Harpagophytum procumbens, inhibits RANKL-induced osteoclastogenesis in vitro, and suppresses inflammation-induced bone loss in mice by suppressing ERK, JNK, and Syk-Btk-PLCγ2-Ca2+ signalling, and the activation of c-Fos and NFATc1 [94]. Additionally, it inhibits LPS-induced bone loss in inflammatory osteoporosis. However, it does not prevent ovariectomy-mediated bone erosion in post-menopausal osteoporosis. These results suggest that harpagoside is useful against inflammation-related bone disorders, but not against osteoporosis induced by hormonal abnormalities.