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Antihypertensive effects of oriental drugs in human and SHR
Published in H. Saito, Y. Yamori, M. Minami, S.H. Parvez, New Advances in SHR Research –, 2020
Hideaki Higashino, Aritomo Suzuki, Koichiro Komai
Eucommia ulmoides Oliv. (ref.A, 1990; ref.10a, 1954; ref.10b, 1955; ref.10c, 1959; ref.10d, 1960). When the extract of the bark (5 ml containing 1-2 g crude drug) was injected intravenously to the anesthetized dogs, remarkable hypotensive responses for 2-3 h duration associated with a tachyphylaxis were observed. Intragastric administration of the 5-8 g/kg doses of decoction to three dogs suffering from renal hypertension daily for 4 weeks caused only 8-22 mmHg (4-10%) reduction in SBP, and no favorable effect for the hypertensive animals was found. Low doses of this drug caused vasodilation in the ear artery of normal rabbit, but not in arteriosclerotic animals. The components and mechanism of the actions remain unclear at present.
THE PROGRESS OF CHINESE MEDICINE IN MAINLAND CHINA
Published in Kevin Chan, Henry Lee, The Way Forward for Chinese Medicine, 2001
Kelvin Chan, Xin-Min Liu, Yong Peng, Pei-Gen Xiao, Wei-Yi Yang
Acacia catechu (st), Achyranthes bidentata (rt), Act^nitum carmtchaelt (rhz), Alpinia oxyphylla (fr), Alisma orientale (rhz), Allium tuberosum (sd), Amomum villosum (fr), Angelica dahurica (rt), A. sinensis (rt). Andrographis paniculata (pl), Areca catechu (sd), Artabotrys hexapelatus (fl), Artemisia argyi (l), Asparagus cochinchinensis (rt), Aster tataricus (rt), Astragalus mongholicus (rt). Atractylodes macrocephala (rhz), Atropa belladonna (l), Aucklandia lappa (rt), Biota orientale (sd), Brassica juncea (sd), Carthamus tinctorius (fl), Cassia acutifolia (l), C. obtusifolia (sd), Celosia cristat (fl), Chaenomeles speciosa (fr). Cinchona ledgeriana (l), C. grandis (exocarp), Citrus aurantium (fr), C. Medica var. sarcodactylis (fr), C. reticulata (exocarp), Codonopsis pilosula (rt), Coix lacryma-jobi var. ma-yuan (sd), Coptis chinensis (rhz), Cornus officinalis (fr), Corydalis yanhuosu (rhz), Crataegus pinnatifida (fr), Crocus sativus (stigma), Curcuma aromatica (rhz). C. domestica (rhz), C. zedoaria (rhz), Cymbopogon citratus (l), Datura metel (fl), D. innoxia (fl), Dendranthema morifolium (fl), Dendrobium morifolium (fl), Dendrobium nobile (pl), Digitalis lanata (l), Dioscorea opposita (rhz), Dolichos lablab (sd), Eriobotrya japonica (l), Eucalyptus globulus (l), Eucommia ulmoides (bk), Euphorbia longan (aril), Eupatorium fortunei (l), Eurya leferox (sd), Evodia rutaecarpa (fr), Foeniculum vulgare (fr).
Integrative hyperthermia treatments for different types of cancer
Published in Clifford L. K. Pang, Kaiman Lee, Hyperthermia in Oncology, 2015
Clifford L. K. Pang, Kaiman Lee
Herbal medicines and acupuncture were applied during the whole process of the treatment. The aforementioned treatment program was applied for 5 weeks. At the intervals, whole-body hyperthermia and peritoneal perfusion were conducted three times each in combination with a variety of treatments such as nutrition, chelation detoxification, medical ozone, acupuncture, and TCM. The patient’s condition was improved markedly, hemoglobin was stabilized at about 95 g/L, weight was increased by 0.6 kg/week, black stools did not appear, and appetite returned to normal. At that time, adjusted peritoneal perfusion drugs and cisplatin plus mitomycin were given. The patient showed leukopenia with WBC reduced to 1.2 × 109/L after adjusting treatment. GM-CSF was applied as well as herbal medicines: Sunburn radix Astragali 30 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Cornu cervi Degelatinatum 15 g, Semen persicae 10 g, safflower 10 g, Fried atractylodes macrocephala Koidz 15 g, Fructus corni 15 g, Donkey-hide Glue (molten) 15 g, Carapax trionycis (Predecoct) 15 g, Carapax trionycis (Predecoct) 15 g, Salvia miltiorrhiza 10 g, with three slides of ginger, five pieces of jujube as the guide, one dose a day. Decocted with water for oral administration. The original program for chelation detoxification, and medical ozone was maintained. Conducted acupuncture and simultaneously Astragalus injection was given at the acupoint of Zusanli. Leukopenia was stabilized and WBCs were normal after 3 days. Conducted this program for more than a month. Conduct whole-body hyperthermia once every 10 days, and combined with medical qigong therapy in the course of treatment.
Aucubin slows the development of osteoporosis by inhibiting osteoclast differentiation via the nuclear factor erythroid 2-related factor 2-mediated antioxidation pathway
Published in Pharmaceutical Biology, 2021
Yongfeng Zhang, Xin Liu, Yangyang Li, Minkai Song, Yutong Li, Anhui Yang, Yaqin Zhang, Di Wang, Min Hu
The perennial woody plant Eucommia ulmoides Oliver (Eucommiaceae), which is found in China (mainly in the provinces of Yunnan, Guizhou and Sichuan) and in the United States, Japan, and some European countries (Wang et al. 2020), is valued as a rich source of polysaccharides, hemicellulose, lignin, and fatty acids and has been reported exhibit various pharmacological (e.g., antibacterial, antioxidant, immune-enhancing and anti-inflammatory) effects (Yan et al. 2018). Extracts of the cortices or leaves of E. ulmoides can regulate OP caused by ovariectomy (Zhang et al. 2009; 2012). Aucubin (AU) (structure in Figure S1), an iridoid glycoside present in all parts of E. ulmoides, and also found in Rehmannia glutinosa Gaertner (Orobanchaceae) and plantain [Musa paradisiacae Linn (Plantaginaceae)], has anti-inflammatory, antioxidant, and hepatoprotective effects (Shen et al. 2019). Our research group has demonstrated that AU slows the development of OP by promoting osteoblast differentiation in MG63 cells and in mice with dexamethasone (Dex)-induced OP (Li et al. 2018, 2020). However, the effects of AU on the osteoclast differentiation have not been systematically explored in cells or in OP mice.
DEC-205 receptor-mediated long-circling nanoliposome as an antigen and Eucommia ulmoides polysaccharide delivery system enhances the immune response via facilitating dendritic cells maturation
Published in Drug Delivery, 2020
Haibo Feng, Xiaonong Yang, Jing Fan, Linzi Zhang, Qianqian Liu, Dongkun Chai
Over the past few years, various studies have demonstrated the adjuvant effect of a myriad of traditional Chinese medicinal plant polysaccharides on the antigen-specific humoral and cellular immune responses in pathogenic infections (Feng et al., 2013, 2015; Sun et al., 2018). Plant polysaccharides have several advantages over other adjuvants, such as better safety and tolerability, and easy to manufacture formulation. Thus, the plant polysaccharides have the potential of being used as adjuvants for the vaccines against infectious agents and malignancies. The Eucommia ulmoides Oliv. (EU) is Chinese traditional medicine with multiple pharmacological activities. In our previous study, we have found that the polysaccharides extracted from E. ulmoides Oliv. (EUPS) regulated DCs maturation and served as an immune-enhancer; besides, it activated the DCs, and promoted the antigen-specific humoral and cellular response (Feng et al., 2016).
Molecular mechanistic insight into the anti-hyperuricemic effect of Eucommia ulmoides in mice and rats
Published in Pharmaceutical Biology, 2019
Cong Fang, Lanying Chen, Mingzhen He, Yingying Luo, Mengjing Zhou, Ni Zhang, Jinfeng Yuan, Huiling Wang, Yongyan Xie
Eucommia ulmoides Oliver (Eucommiaceae), a Chinese traditional medicine, is used as a tonic in China, Japan, Korea, and other countries (He et al. 2014). E. ulmoides contains enriched chemical components such as lignans, iridoids, phenylpropanoids, flavonoids, and phenol, which possess various medicinal properties (Hussain et al. 2016; Yan et al. 2018). It has been used as a functional food to strengthen muscles, improve liver and kidney function, and increase life expectancy (Yen and Hsieh 2000). E. ulmoides also has a protective effect on renal function in mice and rats (Niu et al. 2016; Do et al. 2018). Geniposidic acid and chlorogenic acid are used to authenticate E. ulmoides, according to the Chinese Pharmacopoeia. Geniposidic acid, chlorogenic acid, geniposide, pinoresinol diglucoside, rutin, and quercetin are the primary components of E. ulmoides (He et al. 2014). Previous studies have demonstrated that chlorogenic acid, rutin, and quercetin exert an anti-hyperuricaemia effect in hyperuricemic mice (Hu et al. 2012; Chen et al. 2013; Meng et al. 2014; Xie et al. 2015; Ferraz-Filha et al. 2017). Therefore, we hypothesized that it may have a protective effect on hyperuricaemia.