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Managing Pain in the Presence of Autoimmune Disease
Published in Sahar Swidan, Matthew Bennett, Advanced Therapeutics in Pain Medicine, 2020
For a very long time, people have used colloidal silver to treat infections. Silver is a great antimicrobial. Colloidal silver, however, is not very powerful and has to be used in high doses. It can never be used for long durations as it can produce toxic levels that can actually turn people blue. This is not good. Silver preparations formulated like the pH structured silver solution, a nanosilver, are able to work well at low doses. Thus, people could use much more every day then we would ever need to use and use it for many decades and never come close to a toxic level. Typically, because mycoplasma likes to create pain issues and brain problems, the recommendation is to continue the nanosilver until the pain and brain issues are gone. If, after stopping the silver solution, the person starts to backslide, including feeling the pain returning, then restart the silver solution immediately. Use it for 2 more months and then try to come off it again. This can be repeated as often as necessary until the person feels fine without it. Then we know all the chronic infections are gone. Typically, any other infection will be gone by the time the mycoplasma has been cleared. Dosing often times starts at 4 ounces once a day (done as a swish and swallow for 1–2 minutes) for 4 days, then 2 ounces a day.
Skin manifestations of poisoning
Published in Biju Vasudevan, Rajesh Verma, Dermatological Emergencies, 2019
Large doses of inorganic silver salts such as silver nitrate if ingested have a corrosive effect on the GI tract leading to abdominal pain, vomiting, and diarrhea. Respiratory tract irritation occurs if inhaled. Severe toxicity may progress to decreased blood pressure, depressed respiration, convulsions, and shock [47], although these corrosive effects are likely to be due to the nitrate in the compound rather than to the silver itself [47]. Organic silver compounds, such as colloidal silver, are less toxic but may have effects like pleural edema, hemolysis, and coma if consumed in large doses [49].
Bioinspired Synthesis of Silver Nanoparticles: Characterisation, Mechanism and Applications
Published in Huiliang Cao, Silver Nanoparticles for Antibacterial Devices, 2017
Neeraj S. Thakur, Bharat P. Dwivedee, Uttam C. Banerjee, Jayeeta Bhaumik
Metal nanoparticles have been studied and applied in many areas including the biomedical, agricultural and electronic fields (Mittal et al. 2013). Several products of colloidal silver are already in the market. Research on new, eco-friendly and cheaper methods has been initiated. Biological production of metal nanoparticles has been studied by many researchers owing to the convenience of the method that produces small particles stabilised by protein. However, the mechanism involved in this production has not yet been elucidated, although hypothetical mechanisms have been proposed in the literature (Mittal et al. 2014). Thus, this chapter discusses the various mechanisms provided for the biological synthesis of silver nanoparticles (AgNPs) by plants, fungi and bacteria. One thing that is clear is that the mechanistic aspects in some of the biological systems need more detailed studies.
Preparation and characterization of hydroxyapatite nanoparticles doped with nickel, tin, and molybdate ions for their antimicrobial effects
Published in Drug Development and Industrial Pharmacy, 2023
Maryam Mollaei, Jaleh Varshosaz
Metal ions like Ag+, Cu2+, and Zn2+ are commonly used as antimicrobial agents [28]. Low concentrations of these ions are not harmful to mammals, but they can cause cytotoxicity and allergies at high concentrations [6]. Infection raises the cost of care enormously because it requires further surgery and prolongs the recovery of the patient. There is no appropriate protection for the use of antibiotics in implants or for oral use before surgery [9]. In fact, incorrect antibiotics or low doses of antibiotics may create resistant bacterial strains that are difficult to treat [24,29,30]. Doping synthetic materials with some metal ions (such as Ag+, Cu2+, and Zn2+) is more suitable because they display antimicrobial activity at the implanting site and are not harmful at low concentrations [9]. For the activity of nanoparticles as antibacterial agents, electrostatic interaction between negatively charged bacterial cells and positively charged nanoparticles is important [31]. Several in vitro studies have shown that silver, copper, and zinc ions play a significant role in preventing or minimizing bacterial adhesion in implant coatings [22,24,32,33]. The biocidal activity of colloidal silver nanoparticles depends on their particle size, the smaller the particles, the greater the antimicrobial effect [34]. However, the problems of nanoparticle aggregation are well known. Using nanoparticles available at various substrate is a common approach to avoid this disadvantage [22].
Gestational exposure to silver nanoparticles enhances immune adaptation and protection against streptozotocin-induced diabetic nephropathy in mice offspring
Published in Nanotoxicology, 2022
Ratnakar Tiwari, Radha Dutt Singh, Sukhveer Singh, Diksha Singh, Anurag Kumar Srivastav, Mahadeo Kumar, Vikas Srivastava
The increasing availability of nanomaterial-containing goods on the market necessitates the toxicological evaluation of AgNPs for human and environmental health safety. Daily oral intake of AgNPs depends on the usage of AgNPs containing products and there is very limited data that predicts the AgNPs exposure range. The quantity of silver exposure from AgNPs containing supplements and foods can be several times higher than typical silver exposure. Silver exposure can go up to 450–600 µg/day by consuming 15–20 mL of 10–30 mg/L colloidal silver products (Leino et al. 2021). Previous studies have employed oral exposures ranging from 0.25 mg/kg body weight/day to 300 mg/kg body weight/day in mice and documented substantial effects starting at 1 mg/kg body weight/day (Jia et al. 2017; Nallanthighal et al. 2017; Park et al. 2010). We selected 0.5 mg/kg body weight/day as a low dose and 2 mg/kg body weight/day as a high dose based on our previous study (Tiwari et al. 2021) and relevant literature to better understand the long-term effects of prenatal AgNPs exposure on offspring.
Serum ceruloplasmin monitoring in a case of silver intoxication due to intravenous silver infusion
Published in Clinical Toxicology, 2022
Chun-yiu Law, Siu-chung Leung, Florence Loong, Tsz-ki Ling, Ka-chung Wong, Nike Kwai-cheung Lau, Sik-hon Tsui, Ching-lung Lai, Ching-wan Lam
The medicinal use of silver is mainly in wound treatment. To-date, silver is being packaged as a dietary supplement and is available online in the form of colloidal silver. Colloidal silver refers to tiny silver particles of 1 µm to 1 nm in diameter prepared in liquid. Silver particle of less than 100 nm diameter is regarded as nanoparticles [1]. The beneficial effects of colloidal silver are controversial [2] while there is an increasing concern about its safety profile [3,4]. In animal studies, silver is widely distributed in multiple organs and tissues upon exposure [5]. In humans, a well-known silver depositional effect, argyria was first described in 1840 as a slate-grey skin discoloration. Data on toxicity after injection of silver are scarce. Here, we report a case of chronic silver infusion and its potential toxic effects.