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Nutraceuticals in Maternal Infections
Published in Priyanka Bhatt, Maryam Sadat Miraghajani, Sarvadaman Pathak, Yashwant Pathak, Nutraceuticals for Prenatal, Maternal and Offspring’s Nutritional Health, 2019
Param Patel, Sujan Patel, Parth Amin, Yashwant Pathak
There are a wide variety of plants that protect against maternal infections. Plants used by Cameroonians have been shown to have antifungal, anti-inflammatory, anti-asthmatic, antimicrobial, and antihepatotoxic effects pre-gestation. This indicates that many of these substances have benefits for both the mother and foetus. Issues such as foetal mal-positioning can be treated mainly by Senecio biafrae, which is a plant that healers use to treat maternal infections. Other plants such as Bidens pilosa and Tetrapleura tetraptera are beneficial for placental retention and foetal development [17].
Plant Species from the Atlantic Forest Biome and Their Bioactive Constituents
Published in Luzia Valentina Modolo, Mary Ann Foglio, Brazilian Medicinal Plants, 2019
Rebeca Previate Medina, Carolina Rabal Biasetto, Lidiane Gaspareto Felippe, Lilian Cherubin Correia, Marília Valli, Afif Felix Monteiro, Alberto José Cavalheiro, Ângela Regina Araújo, Ian Castro-Gamboa, Maysa Furlan, Vanderlan da Silva Bolzani, Dulce Helena Siqueira Silva
The 25 species from the Atlantic Forest are listed as follows: Anacardium occidentale (“cajueiro”), Ananas comosus (“abacaxi”), Apuleia ferrea (“pau-ferro”), Arrabidaea chica (“crajiru”), Baccharis trimera (“carqueja”), Bauhinia spp. (“pata-de-vaca”), Bidens pilosa (“picão-preto”), Casearia sylvestris (“guaçatonga”), Copaifera spp. (“Copaíba”), Cordia spp. (“erva-baleeira”), Costus spp. (“cana-do-brejo”), Erythrina mulungu (mulungu”), Eugenia uniflora (“pitanga”), Jatropha gossypiifolia (“pinhão-roxo”), Lippia sidoides (“alecrim-pimenta”), Maytenus spp. (“espinheira-santa”), Mikania spp. (“guaco”), Passiflora spp. (“maracujá”), Phyllanthus spp. (“quebra-pedra”), Portulaca pilosa (“amor-crescido”), Schinus terebinthifolius (“aroeira-vermelha”), Solanum paniculatum (“jurubeba”), Solidago microglossa (“arnica-brasileira”), Tabebuia avellanedae (“ipê-roxo”) and Vernonia spp. (“assa-peixe”).
Protecting Pancreatic β-cells from Metabolic Insults
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Ubillas et al. (2000) provided evidence that ethanol fraction of Bidens pilosa L. given to genetically obese diabetic db/db mice at 0, 8, and 24 hours orally at a dose 1g/kg evoked at 27 hours a 33% fall in glycemia.283 From this fraction, a mixture containing 2-β-d-glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-triyne and 3-β-d-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne given to db/db mice at 0, 8, and 24 hours orally at a dose of 500 mg/kg evoked at 27 hours, a 41% decrease in glycemia and this effect was equivalent to metformin at 250 mg/kg.283 Cytopiloyne or 2-β-d-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne isolated from the leaves of Bidens pilosa L. administered at single oral dose of 0.5 mg/kg to diabetic db/db mice after food intake lowered after 1 hour plasma glucose from 333.1 to 173.4 mg/dL (glimepiride at 1 mg/kg: 270.3 mg/dL), increased plasma insulin from 10.2 to 18.6 ng/mL at 1 hour (glimepiride at 1 mg/kg: 20.3 ng/mL) at 1 hour.284 This polyacetylenic glucoside given orally at a daily dose of 0.5 mg/kg for 28 days lowered glycemia from about 600 to 350 mg/dL and this effect was superior to as glimepiride 1 mg/kg/day with about 400 mg/dL and increased plasma insulin from about 4 to 16 ng/mL, an effect superior to glimepiride at 1 mg/kg/day.284 This polyacetylenic glucoside in RIN-m5F cells, increased cytoplasmic calcium, diacylglycerol, and insulin secretion.285 In must be noted that cytopiloyne attenuated the development of diabetes in non-obese diabetic mice via T cell regulation.285,286 It implies that this polyacetylene glucoside or Bidens pilosa L., if not toxic could be of value for the prevention of type 2 diabetes in metabolic syndrome.
Protective effects of Bidens pilosa on hepatoxicity and nephrotoxicity induced by carbon tetrachloride in rats
Published in Drug and Chemical Toxicology, 2021
Cristiane Martinez Ruiz Pegoraro, Gisele Alborghetti Nai, Leonardo Alves Garcia, Fernanda de Maria Serra, Juliana Apolônio Alves, Pedro Henrique Nahas Chagas, Décio Gomes de Oliveira, Marcos Alberto Zocoler
Bidens pilosa (BP) (Asteraceae) is a plant native to tropical America with anti-inflammatory properties that have been used to treat hepatitis, laryngitis, headache, and digestive disorders (Bartolome et al. 2013). Its broad pharmacological applications are attributed to its chemical composition of flavonoids, which are potent antioxidants (Abajo et al. 2004). In addition, BP is rich in polyunsaturated fatty acids, which are considered key compounds with anti-inflammatory effects (Quaglio et al. 2014). A study of Bidens frondosa using spectroscopic methods revealed the significant anti-inflammatory activity of this plant (Le et al.2015). BP was able to inhibit NF-κB (factor nuclear kappa B) expression and reduce the production of interleukin (IL)-8, tumor necrosis factor (TNF)-α and nitric oxide in vascular endothelial cells from children with Henoch-Schönlein purpura in vivo (Fei et al. 2016). This plant also exerted other beneficial effects such as hypocholesterolemic activity (Moreno-Pena et al. 2017), antidiabetic and hypoglycemic activity (Orhan et al.2016) and antiobesity effects, as well as a significant decrease in adipogenesis and lipid accumulation of lipids. Long-term effects, such as a significant decrease in the fat content and increase in the protein content, were also observed (Liang et al.2016).