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Chemopreventive Agents
Published in David E. Thurston, Ilona Pysz, Chemistry and Pharmacology of Anticancer Drugs, 2021
Berberine is found in the stems, roots, rhizomes, and bark of berberis species such as berberis (Berberis aquifolium, also known as Oregon grape), barberry (Berberis vulgaris), and tree turmeric (Berberis aristata), from which its name is derived. However, it is also found in plants of other genera such as the Californian poppy (Eschscholzia californica), prickly poppy (Argemone mexicana), yellowroot (Xanthorhiza simplicissima), Chinese goldthread (Coptis chinensis), goldenseal (Hydrastis Canadensis), and phellodendron (Phellodendron amurense, also known as the Amur cork tree).
Selected Botanicals and Plant Products That Lower Blood Glucose (Continued)
Published in Robert Fried, Richard M. Carlton, Type 2 Diabetes, 2018
Robert Fried, Richard M. Carlton
Berberine is a naturally occurring yellow plant alkaloid extract with a long history of medicinal use in both Ayurvedic and Chinese medicine—it is also well known in Iranian medicine. It is found in the roots, rhizomes, stems, and bark of various plants including Hydrastis canadensis (goldenseal), Coptis chinensis (Coptis or goldenthread), Berberis aquifolium (Oregon grape), B. vulgaris (barberry), B. aristata (tree turmeric), and Phellodendron amurense (phellodendron), not to be confused with the unrelated household plant, philodendron (No authors listed. 2000).
Antipsoriatic Medicinal Plants
Published in José L. Martinez, Amner Muñoz-Acevedo, Mahendra Rai, Ethnobotany, 2019
José Luis Ríos, Guillermo R. Schinella, Isabel Andújar
Deng et al. (2013a,b, 2017) reviewed and evaluated the efficacy and safety of topically used plant extract preparations by psoriasis patients. A total of twelve studies were investigated, including three with Aloe vera, five with Berberis aquifolium, two with indigo naturalis, one with kukui nut oil (Aleurites moluccanus) and one with Camptotheca acuminata nut. Some of these plant extracts have partial effects on psoriasis symptoms, such as inflammation and cell proliferation. However, the clinical trials analyzed did not provide clear evidences that would support their topical use on psoriatic plaques, probably due to the small size of most studies and methodological weaknesses (Deng et al. 2013a). Similar results were obtained by the same authors after reviewing the evidence for the efficacy and safety of herbal medicines used topically in conjunction with antipsoriatic pharmacotherapy (Deng et al. 2013b). In a third study, they analyzed the efficacy and safety of oral forms of phytotherapy in psoriasis management and discussed the pharmacological actions of the plants used in clinical trials. Their results demonstrated that the most commonly used plants were Oldenlandia diffusa, Rehmannia glutinosa and Salvia miltiorrhiza, which also have anti-inflammatory, anti-proliferative and anti-oxidative properties, which are of relevance to psoriasis management (Deng et al. 2014). In a recent study, these same authors analyzed a preparation formed by different medicinal plants (PSORI-CM01, a modified form of Yinxieling) comparing the results with the original Chinese herbal formula for psoriasis Yinxieling (in tablet) and placebo, and demonstrated in a randomized, double-blinded and multicentral clinical trial, that this formula improved PASI scores and relapse rates in psoriasis vulgaris (Deng et al. 2017). The formula was then modified (PSORI-CM02) eliminating two herbs (liquorice and lithospermum), keeping the remaining five from PSORI-CM01 (Curcumae rhizoma, Radix paeoniae rubra, Rhizoma smilacis glabrae, Mume fructus, and Sarcandrae herba). PSORI-CM02 was tested as a possible suppressor of alloimmunity; results show that it inhibited murine skin allograft rejection and reduced graft-infiltration of CD3+ T cells, which led the authors to hypothetize a potential interest of this new formula against autoimmune psoriasis (Lu et al. 2018).
The effect of co-administration of berberine, resveratrol, and glibenclamide on xenobiotic metabolizing enzyme activities in diabetic rat liver
Published in Drug and Chemical Toxicology, 2022
Azra Bozcaarmutlu, Canan Sapmaz, Ömer Bozdoğan, Aysel Kükner, Leyla Kılınç, Salih Tunç Kaya, Oğulcan Talat Özarslan, Didem Ekşioğlu
There are several plant-derived substances in the form of dietary supplements in drug stores. The effects of most of these products have not been well defined in the presence of a prescribed drug and metabolic disease. Berberine is a bioactive alkaloid found in the roots of many plants including Berberis vulgaris, Berberis aquifolium, Berberis aristata, Hydrastis Canadensis, Rhizoma coptidis, and Coptis chinensis (Chander et al. 2017, Chandirasegaran et al. 2018). It has been used in traditional Chinese medicine for centuries in the treatment of liver disorders, diarrhea, and gastroenteritis (Zhao et al. 2008). In addition to these properties, anti-tumor, anti-microbial, anti-HIV, anti-fungus, antioxidant, cholesterol lowering, and immunosuppressive effects of berberine have been shown (Gudima et al. 1994, Küpeli et al. 2002, Kim et al. 2003, Tran et al. 2003, Volleková et al. 2003, Kettmann et al. 2004, Kong et al. 2004, Racková et al. 2004, Cheng et al. 2006). It is also known that berberine has a hypoglycemic effect (Tang et al. 2006).
Co-encapsulation of metformin and ginger into the liposomes: in vitro characterization and in vivo anti-psoriasis evaluation
Published in Drug Development and Industrial Pharmacy, 2021
Kiana Jenabikordi, Behzad Sharif Makhmal Zadeh, Anahita Rezaie
In addition to Conventional Medicines, medicinal plants have been utilized for the treatment of psoriasis. Aloe vera juice, capsaicin, indigo naturalis, and Berberis aquifolium are the most studied medicinal preparations for the treatment of psoriasis [14].