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Inflammatory Bowel Disease
Published in Mary J. Marian, Gerard E. Mullin, Integrating Nutrition Into Practice, 2017
Wheatgrass juice (triticum aestivum) has antioxidant properties [112] and has been used for the treatment of thalassemias and intestinal diseases for some time now. The main component of wheatgrass is pigenin, which has been shown to block production of proinflammatory cytokines IL-1β, IL-8, and TNF through inactivation of NFκB [113]. A randomized, double-blind, placebo-controlled trial was performed to determine the efficacy of wheatgrass for the treatment of active distal UC. Twenty-three patients were treated for 1 month with either 100 mL of wheatgrass juice or placebo. Treatment with wheatgrass juice was associated with reduction in overall disease activity and degree of rectal bleeding. There was some mild nausea reported with wheatgrass intake. The authors concluded that wheatgrass juice is safe and effective in the treatment of active distal UC [114].
Naringin abrogates angiotensin-converting enzyme (ACE) activity and podocin signalling pathway in cobalt chloride-induced nephrotoxicity and hypertension
Published in Biomarkers, 2023
Ademola Adetokunbo Oyagbemi, Temitayo Olabisi Ajibade, Oluwaseun Olanrewaju Esan, Moses Olusola Adetona, Ayobami Deborah Obisesan, Adewumi Victoria Adeogun, Omolola Victoria Awoyomi, Joseph Ayotunde Badejo, Aduragbenro Deborah A. Adedapo, Temidayo Olutayo Omobowale, Olayinka Israel Olaleye, Olufunke Eunice Ola-Davies, Adebowale Benard Saba, Adeolu Alex Adedapo, Sanah Malomile Nkadimeng, Lyndy Joy McGaw, Prudence Ngalula Kayoka-Kabongo, Momoh Audu Yakubu, Evaristus Nwulia, Oluwafemi Omoniyi Oguntibeju
Naringin, like other flavonoids has a potent free radical scavenging ability. Both Naringin and its aglycone, naringenin have been demonstrated to be potent scavengers of superoxide and hydroxyl radicals (Kong et al.2020, Akamo et al.2021). Extensive studies on Naringin have revealed its anti-inflammatory, anti-cancer, anti-genotoxic, cardioprotective, and ability to improve metabolic syndrome (Yilmaz et al. 2016, Luo et al.2021a; Prakash et al.2022, Rivoira et al.2022, Yadav et al.2022, Liu et al.2022b). Natural products and some pharmacological preparations have been extensively reported to offer protection against kidney injury by anti-inflammatory and anti-oxidative mechanisms (Du et al.2020, Gao et al.2020, Wang et al.2021, Zhou et al.2021, Luo et al.2021b; Wen et al.2022). Hebbani et al. (2020), Mis et al. (2019) and Comba et al. (2017) also reported from their findings the use of wheatgrass as antioxidants against DNA damage in experimental renal failure.
Nephro-protective activity of wheatgrass juice against alcohol-induced oxidative damage in rats
Published in Toxicology Mechanisms and Methods, 2020
Ananda Vardhan Hebbani, Saradamma Bulle, Venkateswarlu Reddy Kanu, Asha Balachandrababu Malini, Vaddi Damodara Reddy, Varadacharyulu Nallan Chakravarthula
Grass of Triticum aestivum (family: Poaceae), commonly known as wheat grass is being reported for its therapeutic and nutritional potentials (Mujoriya and Bodla 2011). Fresh wheatgrass juice is reported to be a rich repository of iron, phosphorus, magnesium, manganese, copper & zinc (Plaza et al. 2003; Padalia et al. 2010). Wheatgrass juice is also shown to be a rich source of tocopherols with many other phytochemical compounds like anthraquinones, saponins, flavonoids, tannins, alkaloids, terpenoids, and phenolics with tremendous antioxidant potential (Durairaj et al. 2014; Suriyavathana and Roopavathi 2016), hypolipidemic (Kothari et al. 2011), hypoglycemic (Shaikh et al. 2011), and hepatoprotective (Durairaj et al. 2015) properties. Also, the WJ has been shown to be a healthy dietary supplementation with better antioxidant potential in comparison to Spirulina (Shyam et al. 2007). Antiproliferative and apoptotic activities of the wheatgrass on myeloid leukemia cells lines (Das et al. 2016; Aydos et al. 2011) and its protection against hematological toxicity related to chemotherapy in patients with breast cancer is being reported (Bar-Sela et al. 2007).
Inhibition of metastasis and angiogenesis in Hep-2 cells by wheatgrass extract – an in vitro and in silico approach
Published in Toxicology Mechanisms and Methods, 2018
Garima Shakya, Sangeetha Balasubramanian, Muddasarul Hoda, Rukkumani Rajagopalan
Wheatgrass (WG) is a young tender grass of common wheat (Triticum aestivum). When it is germinated for the period of 6–10 days, it is at the peak of nutrients like phenols, flavonoids, antioxidants, minerals and various other enzymes. WG also contains vitamin A, B1, C and E, β-carotene, ferulic acid, vanilic acid, many minerals and trace elements including iron, phosphorous, magnesium, manganese, calcium, iodine, selenium, copper and zinc. Certain antioxidant enzymes like superoxide dismutase and cytochrome oxidase are also present in WG. Various reports have shown that WG has several medicinal and therapeutic properties like antioxidant, anticancer, anti-ulcerative, anti-arthritic and blood building activity in thalassemia. It is also reported to act as a detoxifying agent, anti-asthmatic and anti-allergic agent. Earlier WG was consumed in the form of juice because of its widespread therapeutic potential. WG is now commercially available in market in tablet and powdered form as a health supplement (Padalia et al. 2010; Singh et al. 2012; Garima et al. 2014).