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Micronutrients in Improvement of the Standard Therapy in Cancer
Published in Kedar N. Prasad, Micronutrients in Health and Disease, 2019
These results suggest that therapeutic doses of antioxidants or phytochemicals inhibit the growth of cancer cells by bypassing Nrf2-mediated elevation of cytoprotective enzymes and by increasing the levels of proapoptotic pathways. Some of them inhibit cancer growth by inhibiting Nrf2 function, while tert-butylhydroquinone increases the survival of cancer cells. Additional studies on growth-inhibitory effects of individual antioxidants and their potential mechanisms are described here.
Selected Functional Foods That Combat the Effects of Hyperglycemia and Chronic Inflammation
Published in Robert Fried, Richard M. Carlton, Type 2 Diabetes, 2018
Robert Fried, Richard M. Carlton
The journal Marine Drugs published a review titled “Looking beyond the terrestrial: The potential of seaweed derived bioactives to treat non-communicable diseases” (Collins, Fitzgerald, Stanton et al. 2016). The review details the antioxidant and antidiabetic properties of consumable substances in seaweed. In particular, interest in using naturally obtained antioxidants for diabetic treatment has increased due to the inadequacy of synthetic antioxidants such as butylated hydroxyanisol(BHA), butylated hydroxytoluene (BHT) and tert-butylhydroquinone(TBHQ) that are available commercially (Chakraborty, Praveen, Vijayan et al. 2013).
Antioxidant properties and application information
Published in Roger L. McMullen, Antioxidants and the Skin, 2018
tert-Butylhydroquinone (TBHQ) is a synthetic antioxidant that is used to prevent oxidation and stabilize formulations. In addition to its utility in cosmetics, it is a common ingredient in foods, which is added to prevent lipid peroxidation of fats and oils.
Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis
Published in Renal Failure, 2019
Dao-Jing Gong, Lei Wang, Yuan-Yuan Yang, Jian-Jian Zhang, Xiu-Heng Liu
Adult male Sprague Dawley rats weighing 200–220 g were purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd. (Beijing, China). This study was approved by the Committee of the Animal Experimental Center of Wuhan University, and the procedures were conducted in accordance with the Guidelines of the Care and Use of Laboratory Animals. All rats were raised under specific pathogen-free conditions (23 ± 3°C; relative humidity 40–70%) under a 12-h light/dark cycle. All rats were adaptively fed with free access to water and standard rat chow for 1 week before the experiment. To induce RI/RI in a high glucose environment, we randomly divided the rats into four groups (n = 8 per group): (1) normal sham (NS), (2) normal I/R (NI/R), (3) diabetic sham (DS), and (4) diabetic I/R (DI/R). To further demonstrate the effect of tert-butylhydroquinone (TBHQ) on RI/RI in a high glucose condition, we randomly distributed the confirmed diabetic rats into three groups (n = 8 per group): (1) DS, (2) DI/R, and (3) DI/R + TBHQ. After an overnight fast, rats in the diabetic groups were injected intraperitoneally (i.p.) with a single dose of 65 mg/kg STZ (Sigma-Aldrich, St. Louis, MO, USA) dissolved in citrate buffer (0.1 mM, pH 4.5), and rats in the control groups received an equal volume of citrate buffer. Three days after STZ administration, blood was obtained from the tail vein to measure blood glucose level with a glucometer (Terumo, Tokyo, Japan). Animals with random plasma glucose >16.7 mM for three consecutive readings were considered diabetic [26]; these animals were supplied with sufficient normal diet and water ad libitum and housed for another 8 weeks before renal I/R.
Regulation of P-glycoprotein by Bajijiasu in vitro and in vivo by activating the Nrf2-mediated signalling pathway
Published in Pharmaceutical Biology, 2019
Xin Yang, Guoyan Hu, Lijuan Lv, Ting Liu, Longkai Qi, Guozhan Huang, Dongqing You, Jun Zhao
Rhodamine 123, doxorubicin, verapamil, and tert-butylhydroquinone (tBHQ) were purchased from Sigma-Aldrich (St. Louis, MO). Primary antibodies against human P-gp, Keap1 and Nrf2 were purchased from Abcam, Inc. (Cambridge, MA). Primary antibodies against human β-actin and histone H3, siNrf2, and siControl were obtained from Santa Cruz Biotechnologies Inc. (Santa Cruz, CA). Lipofectamine 2000 and TRIZOL were obtained from Invitrogen (Carlsbad, CA). All other chemicals and solvents used were of analytical reagent grade or better.
Evaluation of genotoxic potential of tert-butylquinone and its derivatives in prokaryotic and eukaryotic test models
Published in Drug and Chemical Toxicology, 2020
Jelena Đorđević, Stoimir Kolarević, Jovana Jovanović, Jovana Kostić-Vuković, Irena Novaković, Marko Jeremić, Dušan Sladić, Branka Vuković-Gačić
The study of Bergmann et al. (1992) indicated that tert-butylsemiquinone anion radical is formed from tert-butylhydroquinone and from tert-butylquinone in rat liver microsomes, in the presence of oxygen, the quinone and, less extensively, the hydroquinone induce excess production of superoxide in microsomes. Therefore, experiments in SOS/umuC assay were in parallel performed with addition of S9 fraction. However, S9 fraction has not significantly increased genotoxic potential of compounds.