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Improved Silymarin Characteristics for Clinical Applications by Novel Drug Delivery Systems
Published in Madhu Gupta, Durgesh Nandini Chauhan, Vikas Sharma, Nagendra Singh Chauhan, Novel Drug Delivery Systems for Phytoconstituents, 2020
Maryam Tabarzad, Fatemeh Ghorbani-Bidkorbeh, Tahereh Hosseinabadi
Successful niosomal formulations containing sorbitan monostearate (Sp 60) or sorbitan monopalmitate (Sp 40) as non-ionic surfactant, and cholesterol were prepared with efficient encapsulation of silymarin that showed spherical shape and a bilayered structure. In vitro biphasic release profiles with an initial fast release followed by a period of slow release were observed. On rats, an in vivo study proved the significantly improved hepatoprotective effect of niosomal formulations. Subcutaneous administration of these formulations might increase drug bioavailability. Histopathological investigation confirmed the safety of these niosomal formulations (El-Ridy et al., 2012).
Advances in Capsule Formulation Development and Technology
Published in Larry L. Augsburger, Stephen W. Hoag, Pharmaceutical Dosage Forms, 2017
Larry L. Augsburger, Stephen W. Hoag
Lipid-based drug delivery systems can be complex compositions of three main classes of components: lipids, surfactants, and, possibly, cosolvents.25,26 The lipid may be a single lipid or a blend of fatty materials. The most important lipids are fatty acids or their derivatives (e.g., mono-, di-, and triglycerides, and propylene glycol esters). They are either solid or liquid at room temperature, depending on their chain length and degree of unsaturation of the fatty acid chains. The presence of the surfactant (emulsifier) assists in the breakup and dispersion of the capsule content in gastrointestinal fluids. Typically, these are the non-ionic type (e.g., polyoxyl 40 stearate, polysorbate 80, and sorbitan monopalmitate) of varying HLB values. Cosolvents (e.g., alcohol, polyethylene glycol 400, and propylene glycol) may be included to help solubilize the drug substance.
An examination of carbopol hydrogel/organogel bigels of thymoquinone prepared by microwave irradiation method
Published in Drug Development and Industrial Pharmacy, 2020
Evren Algin Yapar, Sakine Tuncay Tanriverdi, Gulsen Aybar Tural, Zinar Pınar Gümüş, Ezgi Turunç, Evren Homan Gokce
Bigels were characterized with different techniques aiming at investigating the material microstructure and the mutual position of the structured phases [31]. Rheological methods were used by Behera et al. [32], Satapathy et al. [33], and Singh et al. [34]. Behera et al. [32] prepared bigels by conventional heating varying the concentrations of PVA and PVP solutions. Sorbitan monopalmitate was dissolved in sun flower oil at 50 °C to form a clear mixture of oil and gelator. Similar to this study, the results of the current study revealed that the viscosity of the bigels increased with the increasing polymer ratio and exhibited a shear – thinning phenomena. Satapathy et al. [33] prepared bigels with sesame oil, tween 80, gelatin, and glutaraldehyde with conventional heating method. Similar to data determined by the mentioned study, bigel formulations prepared were also intact, and not completely deformed.
Evaluation of bilosomes as nanocarriers for transdermal delivery of tizanidine hydrochloride: in vitro and ex vivo optimization
Published in Journal of Liposome Research, 2019
Rawia M. Khalil, Ahmed Abdelbary, Silvia Kocova El-Arini, Mona Basha, Hadeer A. El-Hashemy
TZN was kindly donated as a gift sample by Hi pharm Co., Cairo, Egypt. Span 20® (sp20) (sorbitan monolaurate), Span 40® (sp40) (sorbitan monopalmitate), Span 60® (sp60) (sorbitan monostearate), Carboxy methylcellulose (CMC), and cellulose membrane with molecular weight cutoff 12 000–14 000 were purchased from Sigma-Aldrich (St. Louis, MO). Cholesterol PB (95%) (CH) was supplied by Panreac (Barcelona, Spain). Sodium Deoxycholate (SDC) was purchased from BDH laboratory reagents, England (Safat, Kuwait). Chloroform, HPLC, was purchased from Alpha Chemical, Mumbai, India. Potassium dihydrogen phosphate and disodium hydrogen phosphate were of analytical grade.
Topical delivery of l -ascorbic acid spanlastics for stability enhancement and treatment of UVB induced damaged skin
Published in Drug Delivery, 2021
Mona Elhabak, Samar Ibrahim, Samar M. Abouelatta
d-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) was gifted by Isochem (France). LAA was supplied by El-Gomhouria Co. (Egypt). Sorbitan monopalmitate (span 40), sorbitan monostearate (span 60), polyoxyethylene sorbitan monostearate (tween 60), polyoxyethylene sorbitan monooleate (tween 80), polyvinyl alcohol (PVA), methanol, and absolute alcohol (97%) were provided from El-Nasr Pharmaceutical Co. (Egypt). Spectra Por semipermeable membrane tubing (MWCO 12,000–14,000) was obtained from Spectrum Laboratories Inc. (Rancho Dominguez, CA).