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How Research Funding Can Drive the Commercialization of IK-Based Technologies: The Case of SANBio
Published in David R. Katerere, Wendy Applequist, Oluwaseyi M. Aboyade, Chamunorwa Togo, Traditional and Indigenous Knowledge for the Modern Era, 2019
Ereck Chakauya, Zvikomborero Tangawamira, Sechaba Bareetseng
Background: Marula (Sclerocarya birrea subsp. caffra) trees are in high concentrations in several areas of Botswana. With the advent of the natural products revolution, the benefits of African seed oils to human skin, hair, and nails are becoming common knowledge (Vermaak et al., 2011). The chemical composition of marula oil lends itself well to the treatment of stretch marks, scars, blemishes, and uneven skin tone. Its high antioxidative stability makes it perfectly suited for the prevention of the ageing of the skin (Komane et al., 2015). Marula processing has, however, been inefficient due to the lack of suitable technology to extract marula kernels to replace the traditional means of hand-and-stone extraction.
GC/MS analysis and potential synergistic effect of mandarin and marjoram oils on Helicobacter pylori
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Rawah H. Elkousy, Nada M. Mostafa, Ahmed M. Abd-alkhalek, Mahmoud A. El Hassab, Sara T. Al-Rashood, Wagdy M. Eldehna, Omayma A. Eldahshan
Many studies of in vitro antimicrobial activity of marjoram and mandarin oils in the literature may be probably due to the action of the major compounds which have been previously tested for their bactericidal activity, such as terpinen-4-ol, α-terpineol, and γ-terpinene were found as the predominant components of the essential oils obtained from the aerial parts of Origanum scabrum and Origanum microphyllum, both endemic species in Greece, exhibited a very interesting antimicrobial profile after they were tested against six Gram-negative and Gram-positive bacteria and three pathogenic fungi47. Furthermore, the acetone crude extract of the stem bark of Sclerocarya birrea is a promising source for anti-H pylori compounds, with terpinen-4-ol, an essential oxygenated monoterpene oil, being the most abundant agent (35.83%), and it was reported as a major mediator of the anti-H pylori activity48. The inhibitory activity of terpinen-4-ol in this study was similar to that of amoxicillin, one of the most effective drugs used in the eradication of H. pylori infections worldwide49. Additionally, trans-sabinene hydrate, terpinen-4-ol, α-terpineol, and γ-terpinene have been reported as major components of marjoram oil, which exhibited antibacterial activity against food-related bacteria like E. coli, Salmonella cholraesius, and S. aureus in fresh sausage. Because of their antimicrobial activity against food-borne bacteria EOs could be added to food products to extend their shelf life, but changes in the taste, as well as formulation problems, could represent a problem there in21.