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Role of Natural Agents in the Management of Diabetes
Published in Rohit Dutt, Anil K. Sharma, Raj K. Keservani, Vandana Garg, Promising Drug Molecules of Natural Origin, 2020
Monika Elżbieta Jach, Anna Serefko
In a preclinical study with rats fed a high-fructose diet, supplementation of the water extract of G. alypum revealed improvement of plasma triglycerides and lipid peroxidation (Taleb-Dida et al., 2011). A lyophilized ethanolic extract of Tasselgha (1 g/kg a day) reduced glycaemia, values of liver and plasma lipids, levels of VLDL-LDL- and HDL-cholesterol, and lipid peroxidation and ameliorated the reverse transport of cholesterol in the diabetic group (Djellouli et al., 2014). In a comparative study, the impact of oral administration of water extracts of Rubus fructicosis (0–6 g/kg) and G. alypum leaves (2–10.5 g/kg a day) on blood glucose concentration was analyzed in normal and diabetic models. In non-diabetic rats, single, and repeated intake of R. fructicosis reduced significantly concentration of blood glucose, while the therapy with G. alypum did not modify this blood parameter. In diabetic rats, single, and repeated intake of both R. fructicosis and G. alypum caused a significant lessened the levels of blood glucose. The plant treatments did not have an influence on insulin secretion in all groups of rats, showing that the lowering mechanism of blood glucose concentration by these plants is extra-pancreatic, at least for the doses used. Additionally, an acute toxicity study revealed that the water extract of Tasselgha water extract might be considered relatively safe, since the LD50 value was over 14.5 g/kg (Jouad et al., 2002).
GC-MS Analysis of Methanolic Extract of Rubus ellipticus
Published in Parimelazhagan Thangaraj, Phytomedicine, 2020
Elizabeth George, Blassan P. George, Sajeesh Thankarajan, Parimelazhagan Thangaraj, Kasipandi Muniyandi, Saikumar Sathyanarayanan
Rubus is one of the largest genera in the family Rosaceae, and the members are well known as wild edibles with high nutritional and curative values (George et al. 2013; Srivastava et al. 2010). R. ellipticus is used mainly among tribals for gynecological problems, stomach problems, diarrhea, curing bone fracture, relieving stomach worms in children, anti-fertility activity in males, and for edible purposes (Maity et al. 2004; Gupta and Sharma 2006; Pradhan and Badola 2008).
Increasing the Sensitivity of Adipocytes and Skeletal Muscle Cells to Insulin
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Aqueous extract of leaves of Rubus fruticosus L. given orally to Wistar rats at a single dose of 100 mg/kg evoked a reduction of plasma glucose after 2 hours.104 The extract given orally to streptozotocin-induced diabetic Wistar rats at a dose of 100 mg/kg/day for 9 days evoked a reduction of plasma glucose by about 75% similarly to metformin at 500 mg/kg/day.104 This extract had no effect on plasma insulin104 implying, at least, increased glucose uptake by skeletal muscles and adipose tissues.
The effects and molecular mechanism of heat stress on spermatogenesis and the mitigation measures
Published in Systems Biology in Reproductive Medicine, 2022
Yuanyuan Gao, Chen Wang, Kaixian Wang, Chaofan He, Ke Hu, Meng Liang
Rubus apetalus is aqueous and methanolic extracts of R. apetalus, which is a medicinal plant with a powerful antioxidant potential (Li et al. 2021). Research has shown that rubus apetalus boosts fertility potential in cryptorchid rats. Undescended testicles are associated with significant decreases in sperm weight and density, sperm motility, testicular protein, LH, FSH, and testosterone. The observations from the cryptorchidic rat model obtained from surgery showed that the perivascular fibers in the testicles of cryptorchid mice increased significantly, the diameter of the curved seminal ducts and the thickness of the germ cell layer decreased, and the pregnancy index and fertility index decreased. Cryptorchidism induces oxidative stress by increasing LPO and decreasing the activities of SOD and CAT (Karhagomba et al. 2013). In the experiment using the rat model of cryptorchidism, when feeding rubus apetalus extract, for 2 weeks, 4 weeks, and 8 weeks, the cryptorchid rats showed significantly increased sperm vitality and density; in addition, compared with untreated rats with cryptorchidism, levels of testicular protein, pregnancy index, and fertility index increased significantly after treatment for cryptorchidism (Alumeti Munyali et al. 2020).
Effect of Raspberry Ketone on Normal, Obese and Health-Compromised Obese Mice: A Preliminary Study
Published in Journal of Dietary Supplements, 2021
Tahir Maqbool Mir, Guoyi Ma, Zulfiqar Ali, Ikhlas A. Khan, Mohammad K. Ashfaq
Fruits of Rubus idaeus L. commonly known as red raspberries are widely available and possess both nutritional and medicinal properties. They possess several essential micronutrients, dietary fibers, and phenolic components, especially raspberry ketone ellagitannins, and anthocyanins. Scientific reports indicate that raspberries are being used in the treatment of diabetes mellitus, cancer, cardiovascular disorders, obesity, and neurodegeneration (Burton-Freeman et al. 2016; Kristo et al. 2016; Noratto et al. 2016). Raspberry ketone is an aromatic compound predominantly found in raspberries and also in other fruits, including black raspberries and kiwifruit (Ulbricht et al. 2011). It is widely used as a fragrance in cosmetics and flavoring agent in foodstuff. Several reports have demonstrated its lipolytic and anti-obesity activities (Morimoto et al. 2005; Leu et al. 2018; Mehanna et al. 2018). In the present study, we induced obesity in mice by feeding them for 10 weeks on a high-fat diet. Increases in body weight and fat storage was noted in accordance with the previously published reports (Morimoto et al. 2005; Mukai et al. 2016). In addition, we explored the possible adverse effects of consumption of RK during normal obese and health compromised obese condition in mice.
Influence of spray drying on bioactive compounds of blackberry pulp microencapsulated with arrowroot starch and gum arabic mixture
Published in Journal of Microencapsulation, 2020
Gislaine Ferreira Nogueira, Cyntia Trevisan Soares, Luiz Gabriel Pereira Martin, Farayde Matta Fakhouri, Rafael Augustus de Oliveira
Blackberry, originally from Asia, is currently produced in countries of Europe, North America and South America, growing in regions of cold weather (Ferrari et al. 2012). In addition to its attractive colour and flavour characteristics, blackberry (Rubus fruticosus) cv. Tupy is a fruit rich in phenolic compounds, such as phenolic acids, tannins and anthocyanins, which have high antioxidant activity (Machado et al. 2015). Studies with fruits rich in phenolic compounds, specifically anthocyanins, have shown that these bioactive compounds provide functional benefits for humans, reducing free radicals that carry chain reactions able to damage cells, acting in the prevention of certain cancers and cardiovascular diseases, and also acting on the immune system, due to their antioxidant action (Masisi et al. 2016, Leung 2008).