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Engineering Stable Spray-Dried Biologic Powder for Inhalation
Published in Anthony J. Hickey, Sandro R.P. da Rocha, Pharmaceutical Inhalation Aerosol Technology, 2019
Nicholas Carrigy, Reinhard Vehring
The change in relative humidity within packaging over the time of a stability test can be estimated from moisture sorption isotherms and the moisture vapor transmission rate of the packaging system, along with ambient conditions [317]. In practice, it is typical for moisture to transfer quickly from the dosage form to the desiccant until the relative humidity is equilibrated; thereafter, external moisture will slowly enter the packaging and increase the water content of the powder and desiccant over time [317].
Development of probiotic orodispersible tablets using mucoadhesive polymers for buccal mucoadhesion
Published in Drug Development and Industrial Pharmacy, 2020
Anja Hoffmann, Joerg T. Fischer, Rolf Daniels
As active principal a probiotic model strain, Lactobacillus plantarum Lp299v (Lp299v) was chosen. This strain had been isolated from oral mucosa [30] and it is used as starter culture in industrial production of fermented products [31,32]. Moreover, it is a well characterized bacterium with documented safety, and it is generally recognized as safe (GRAS) from the FDA [33]. For the final probiotic product high cell counts and long shelf life stability are desired. Probiotic bacteria need to be handled and processed carefully, because they can be harmed during drying and compression [34]. The probiotics in this study were used as freeze-dried material and low compression stress was applied during tabletting to maintain high cell counts [35]. Water activity and storage temperature are the main factors influencing probiotics viability [36]. Consequently, measures were taken to produce ODTs with low water activity, by using excipients for moisture-sensitive actives and providing low air humidity during production. For appropriate storage HD-PE tablet jars with low moisture vapor transmission rate were used and a desiccant pack was added to maintain low water activity [37].
Personal protective equipment during COVID-19 pandemic: a narrative review on technical aspects
Published in Expert Review of Medical Devices, 2020
Sai Saran, Mohan Gurjar, Arvind Kumar Baronia, Ayush Lohiya, Afzal Azim, Banani Poddar, Namrata S. Rao
Any fabric is comfortable only if water vapor or moisture is easily transmissible and gases like nitrogen, oxygen, and carbon-dioxide easily pass through[19]. Although ideal requirements are debatable, the fabric used for a surgical gown requires water vapor transmission rate (WVTR) or moisture transmission rate (MVTR) (grams/m2/day) of 400–600 and air permeability of at least 100 L/m2/min [19].