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Heavy Metal Poisoning
Published in Charles Theisler, Adjuvant Medical Care, 2023
Ascorbic Acid: Vitamin C supplements and vitamin C rich fruits such as gooseberries provide protection against metal induced hepatotoxicity.1 Apart from its well-established antioxidant properties, vitamin C has been reported to act as a chelating agent of lead (Pb), with a similar potency to that of EDTA. Probably due to this chelating capacity, a significant decrease in blood Pb was observed in a study of 75 adult smokers receiving 1 gm vitamin C daily for one week.2
Meat
Published in Christopher Cumo, Ancestral Diets and Nutrition, 2020
By increasing mobility, the horse prompted Plains Indians to concentrate on bison, which they had hunted since roughly 8000 BCE.112 During much of the nineteenth century, firearms could not be reloaded quickly enough for the hunt, a problem that breechloading rifles solved around 1870. In addition to meat, Plains Indians ate prairie turnips (Psoralea esculenta), wild artichokes (Cynara cardunculus), wild onions (Allium canadense), chokecherries (Prunus virginiana), gooseberries (Ribes uva-crispa), buffaloberries (Shepherdia species), elderberries (Sambucus nigra), wild plums (Prunus americana), sand cherries (Prunus pumila), ground beans (Falcata comosa), sunflower seeds (Helianthus annuus), prickly pears (Opuntia species), and nuts from several tree species. Trade expanded diets to include corn, beans (Phaseolus vulgaris, P. lunatus, P. acutifolius, and P. coccineus), and squashes (Cucurbita species).
Fruits, Vegetables and Tubers
Published in Bill Pritchard, Rodomiro Ortiz, Meera Shekar, Routledge Handbook of Food and Nutrition Security, 2016
A wide range of other temperate zone berry crops add variety and interest to the world’s fruit basket. They include crops of the genus Vaccinium (blueberries and cranberries), Rubus (raspberries and blackberries) and Ribes (currants and gooseberries). The total production of these fruits amounts to roughly 3.3 MMT.
Possible radioprotection of submandibular glands in gamma-irradiated rats using kaempferol: a histopathological and immunohistochemical study
Published in International Journal of Radiation Biology, 2023
Salwa Farid Ahmed, Noura Mohammed Bakr, Nora Abdelgawad, Dina W. Bashir
Kaempferol, a natural flavonol-type flavonoid, is found in various fruits and vegetables including beans, broccoli, cabbage, gooseberries, grapes, kale, strawberries, tomatoes, citrus fruits, brussels sprouts, apples, grapefruits, and different medicinal plants (Li et al. 2015; Sharifi-Rad et al. 2018). Kaempferol and its glycosylated derivative exert several pharmacological activities, including antioxidant (Suchal et al. 2016), antidiabetic (Chandramohan et al. 2015), anticancer (Yi et al. 2016), and anti-inflammatory effects (Ren et al. 2019). It plays a positive modulating role in inflammatory-mediated conditions, such as cancers, cardiovascular, and neurodegenerative diseases by inhibiting inflammatory cell function and downregulating of pro-inflammatory cytokines and chemokines (Devi et al. 2015). Therefore, this study was designed to evaluate the possible protective effects of kaempferol on the SMGs of rats exposed to fractionated gamma irradiation similar to fractionated therapeutic protocols used in humans.
Aldose reductase inhibitors: 2013-present
Published in Expert Opinion on Therapeutic Patents, 2019
Luca Quattrini, Concettina La Motta
To develop a novel class of ALR2 inhibitors, Daniel Labarbera and Mark Petrash took inspiration from β-glucogallin 51, 1-O-galloyl-β-D-glucose (Figure 8), naturally occurring in gooseberries, Emblica officinalis [90,91] and previously described by the same authors as an effective ALR2 inhibitor [92]. Moving from the natural hit, they obtained a novel series of polyphenolic compounds, 52–57 (Figure 8), by tying together the two key portion of 51, namely the sugar moiety and the phenolic ring, with different heteroaromatic linkages. Among the synthesized compounds, the β-glucogallin amide 52 proved to be active against the target enzyme, showing no inhibitory efficacy against the related aldo-keto reductases AKR1B10 and AKR1A1. Moreover, it demonstrated to block sorbitol accumulation both in Raw264.7 murine macrophages and in lens obtained from PAR40 transgenic mice, expressing human ALR2, once excised and cultured ex vivo. These experimental results provide the evidence that the analogs of β-glucogallin proposed by the authors might be profitably exploited for the prevention, the treatment and the prophylaxis of chronic diabetic complications, in particular, those affecting the visual system.