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Copper nanoparticles synthesis optimization using melinjo (Gnetum gnemon L.) leaves extract and beta cyclodextrin as a stabilizer
Published in Ade Gafar Abdullah, Isma Widiaty, Cep Ubad Abdullah, Medical Technology and Environmental Health, 2020
H.A. Wisnuwardhani, R.D. Shafira, Y. Lukmayani, A. Arumsari
Melinjo (Gnetum gnemon L.) is one of the local commodities that has several benefits. Melinjo is widely cultivated in Indonesia, but the usage of this plant is limited to its usage as vegetables and as a material of emping (kind of melinjo chips in Indonesia). According to Pudjiatmoko (2007), the antioxidant activity of the phenolic content in melinjo is equivalent to the synthetic antioxidant Butylated Hydroxytolune (BHT). Chemical content contained in melinjo seeds and leaves are saponins, flavonoids, and tannins while melinjo skins contain saponins and flavonoids.
The Effect of Resveratrol on Cellular Senescence in Normal and Cancer Cells: Focusing on Cancer and Age-Related Diseases
Published in Nutrition and Cancer, 2019
Hossein Farhadnejad, Hadi Emamat, Hamid Zand
Further, the decline in telomerase activity as part of molecular clock is positively associated with cellular senescence and aging (37). Therefore, incubation of resveratrol decreases cellular senescence in EPC cells via activation of telomerase related to the PI3K-Akt signaling pathway (38). In this regard, immunoblotting analysis has revealed that resveratrol can lead to phosphorylation and activation of Akt in EPCs (39). Also, resveratrol is a potential candidate for preventing H2O2-induced-oxidative stress leading to aging in endothelial cells. Resveratrol prevented this event through increasing endothelial SirT1 expression. SirT1, as a NAD-dependent histone deacetylase, is an important desired factor for longevity in normal cells (40). Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase, which in cultured endothelial cells exogenously accelerates cell senescence (41). Meanwhile, dimethylarginine dimethylaminohydrolase (DDAH) degrades ADMA (42). High glucose accelerates the senescence of endothelial cells through down-regulation of DDAH (43). Resveratrol derivative BTM-0512 inhibits this high glucose-induced cell senescence pathway (44). Resveratrol slows down the senescence process in aorta endothelial cells of rats fed high-fat/sucrose diet by down-regulating the NADPH oxidase and up-regulating SirT1 (25). In streptozotocin-induced diabetic mice, Gnetum gnemon extract, a rich source of resveratrol, protects against oxidative-stress-induced endothelial senescence via activation of SirT1 (45).