China
Africa
Explore chapters and articles related to this topic
Moringa oleifera (Drumstick)
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
The reduction in the ability of cancer cells to work successfully could be because of the phenolic constituents, particularly isopropyl isothiocyanate, D-allose and eugenol. Eugenol plays a considerable role in the MDAMB231 (breast cancer cells) apoptosis by means of the Bax protein overexpression; it may also provoke apoptosis by means of the E2f1/survivin downregulation in cancer cells of the breast. The hydroxycinnamic acid and hydroxybenzoic acid derivatives in leaf extract of Moringa oleifera could have a potential role in managing and preventing cancer, as stated in numerous studies. The in silico and in vitro outcomes revealed that 4-hydroxy 3-methoxy cinnamic acid, quercetin, P-coumaric acid and gallic acid demonstrated strong anticancerous properties and fine treatment potential against the malignant tumour (Mumtaz et al., 2021).
Monographs of fragrance chemicals and extracts that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Results of studies testing cinnamic acid in consecutive patients suspected of contact dermatitis (routine testing) and those of testing in groups of selected patients (e.g. patients allergic to propolis, individuals reacting to Myroxylon pereirae resin (in which cinnamic acid may be present in concentrations of 3–30% [2]) are shown in table 3.35.1.
Anti-Inflammatory Properties of Bioactive Compounds from Medicinal Plants
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Health Benefits of Secondary Phytocompounds from Plant and Marine Sources, 2021
Muhammad Imran, Abdur Rauf, Anees Ahmed Khalil, Saud Bawazeer, Seema Patel, Zafar Ali Shah
Cinnamon comprises of numerous bioactive constituents like cinnamic acid, cinnamaldehyde, and cinnamate. Bioactive compounds of cinnamon improve with appearance of dark color due to aging of cinnamon. Various essential oils (α-thujene, cinnamyl acetate, L-bornyl acetate, eugenol, E-nerolidol, trans-cinnamaldehyde, L-borneol, terpinolene, caryophyllene oxide, α-terpineol, b-caryophyllene, and α-cubebene) are present in cinnamon extracts. The 2′-hydroxycinnamaldehyde is known to inhibit the formation of nitric oxide by retarding the initiation of NF-κB, signifying the anti-inflammatory potential of this compound. Several bioactive components present in C. ramulus revealed potent anti-inflammatory characteristics due to inhibitory action on expression of NO, iNOSandCOX-2 production in CNS (central nervous system). Therefore, C. ramulus could be a potent nutraceutical agent responsible for preventing neuro-degenerative ailments caused due to inflammation [36].
Research progress of coumarins and their derivatives in the treatment of diabetes
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Yinbo Pan, Teng Liu, Xiaojing Wang, Jie Sun
Cinnamic acid is a natural compound extracted from cinnamon oil. In recent years, the research of this kind of compound and its derivatives in the treatment of type 2 diabetes has become more and more extensive Based on this, Xu et al.41 combined substituted cinnamic acid with 4-hydroxycoumarin (Figure 9, Table 5) and 7-hydroxycoumarin (Figure 10, Table 6), and evaluated the inhibitory effects of these compounds on α-glucosidase. It was found that the inhibitory activity of these compounds on α-glucosidase was much higher than that of cinnamic acid and coumarin, and the inhibitory effect of substituted cinnamic acid combined with 4-hydroxycoumarin on α-glucosidase was better than that of 7-hydroxycoumarin. In addition, the introduction of electron-donating groups such as methyl can enhance its inhibitory activity. Molecular docking studies also confirmed that the synthesised derivatives can be effectively inserted into the active bag of α-glucosidase. Therefore, these compounds may be a promising α-glucosidase inhibitor.
Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Yao Chen, Jie Zhu, Jun Mo, Hongyu Yang, Xueyang Jiang, Hongzhi Lin, Kai Gu, Yuqiong Pei, Liang Wu, Renxiang Tan, Jing Hou, Jingyi Chen, Yang Lv, Yaoyao Bian, Haopeng Sun
The cinnamic acid is a naturally originated compound with diverse biological activity. We notice that several derivatives of cinnamic acid, such as ferulic acid, caffeic acid, are reported to benefit the treatment of AD for many reasons. More importantly, we observe that the cinnamic acid moiety can serve as a good scaffold to insert into the narrow groove of the AChE active site, forming intermolecular interactions with residues in the PAS. Therefore, we consider that cinnamic acid moiety is a good fragment for designing CAS-PAS dual site ChEs inhibitor. However, as a PAS binder, the structural modification of this moiety is not fully analysed previously. Herein, we designed a series of tacrine-cinnamic acid hybrids, and discussed the SAR for these compounds as dual site ChEs inhibitors.
Preventive effect of Euphorbia royleana Boiss on diabetes induced by streptozotocin via modulating oxidative stress and deoxyribonucleic acid damage
Published in Toxin Reviews, 2021
Mehroz Zafar, Ali Sharif, Darosham Khan, Bushra Akhtar, Faqir Muhammad, Muhammad Furqan Akhtar, Tuktum Fatima
The present study exhibited a better tolerability to glucose. An improved anti-hyperglycemic inhibition factor was observed for the 500 mg/kg BW group as compared to glibenclamide-treated group. This reduction in the glucose level in hyperglycemic rat’s plasma might be attributed to the detected caffeic acid and cinnamic acid. The results confirmed the previous claims, where gallic acid was stated for triggering insulin secretion from pancreatic cells (Rahman et al.2011, Khan et al.2020). Cinnamic acid was reported to increase glucose uptake and improve insulin sensitivity in adipose and skeletal tissues, thereby improving glycogen synthesis in the liver (Mohammed and Islam 2018).