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Traditional Malay Ulam for Healthy Ageing
Published in Goh Cheng Soon, Gerard Bodeker, Kishan Kariippanon, Healthy Ageing in Asia, 2022
Jamia Azdina Jamal, Khairana Husain
Puttarak et al. (2017) performed a systematic review and meta-analysis of the effect of Centella asiatica on cognitive abilities. A quantitative synthesis of 11 related papers found no conclusive evidence to support the effect of C. asiatica on overall cognitive performance improvement. However, C. asiatica could improve working memory. When mixed with other herbs, it could improve attentiveness and focus, executive functioning skills and information processing speed. In vitro and in vivo studies conducted by Hafiz et al. (2020) have reported that an ethanol extract (95%) of C. asiatica inhibits acetylcholinesterase, LPS-induced neuroinflammation and oxidative stress. Neuroinflammation is associated with neurodegenerative diseases such as Alzheimer’s disease (AD) and cognitive dysfunction. Agathisflavone isolated from 80% methanol extract of Anacardium occidentale leaves inhibits neuroinflammation in BV2 microglia via activation of immune-related NF-κB signalling pathway (Velagapudi et al. 2018).
Bioactive Constituents in Indian Medicinal Plants Traditionally Recognized for Brain Health Benefits
Published in Abhai Kumar, Debasis Bagchi, Antioxidants and Functional Foods for Neurodegenerative Disorders, 2021
Deepak Mundkinajeddu, Amit Agarwal, Gururaja Giligar Manjunatha, Vineet Kumar Singh
Centella asiatica is a widely available herb that has been in use for centuries in Indian systems of medicine. In India for the past 3,000 years of Ayurvedic medicine, it has been used for the purposes such as boosting memory, improving concentration, alertness, antianxiety antistress, wound healing, and as a mild diuretic (Rathee et al., 2008). It is found in most tropical and subtropical countries. It grows in swampy areas, including parts of India, Pakistan, Sri Lanka, Madagascar, South Africa, and eastern Europe. It is a tasteless, odorless plant that thrives in and around water. It has small fan-shaped green leaves with white or light purple-to-pink flowers, and it bears small oval fruit (Bown, 1995, Singh and Singh, 2002). Fresh whole plant juice is used for therapeutic purposes as “Medhya” cognitive enhancer (Acharya et al., 1994). The plant is also used as part of food items in many parts of India (Table 18.8).
Aquatic Plants Native to Africa
Published in Namrita Lall, Aquatic Plants, 2020
Karina M. Szuman, Mala V. Ranghoo-Sanmukhiya, Joyce Govinden-Soulange, Namrita Lall
Centella asiatica is a herb that is used to treat skin diseases, wound healing, and leprosy (Chopra et al. 1956). It is used for revitalizing the nerves and brain cells (Hong et al. 2005, Shetty et al. 2006).
Centella asiatica L. Urban protects against morphological aberrations induced by chronic unpredictable mild stress in rat’s hippocampus via attenuation of oxidative stress
Published in Egyptian Journal of Basic and Applied Sciences, 2022
Saravanan Jagadeesan, Samaila Musa Chiroma, Mohamad Aris Mohd Moklas, Mohamad Taufik Hidayat Baharuldin, Che Norma Mat Taib, Zulkhairi Amom, Thirupathirao Vishnumukkala, Warren Thomas, Onesimus Mahdi
Centella asiatica L. Urban (CA) is a green leafy herb that is valued for its medicinal properties and has been used in traditional medicines of many countries since ancient times [21]. The health benefits of CA have been described in Unani medicine in Sri Lanka, Ayurvedic medicine in India, Chinese traditional medicine, folk medicine in South Asian countries, and African traditional medicine [30]. Centella asiatica has been used for its neurological actions including memory-enhancing effects [31], and as a revitalizer for nerves and brain cells [32]. More broadly, CA has also been used for the treatment of headache and leprosy [33] wound healing, and memory enhancement [34]. Centella asiatica is most commonly used in many traditional medicinal practices for its neuroprotective effects [26,3536]. The ameliorative effects of CA on d-galactose and aluminum chloride-induced oxidative stress and cholinergic dysfunction causing neuronal degeneration, and cognitive impairment in male Wistar rats [37] and lead-induced toxicity in rats [38] have also been documented.
Anti-quorum sensing, antibiofilm, and antibacterial activities of extracts of Centella asiatica L. leaves, and in vitro derived leaves-calli through tissue culture: a potential for biofouling-prevention
Published in Biofouling, 2022
Mo Ahamad Khan, Haris M. Khan, Irfan Bashir Ganie, Sachin Kumar, Anwar Shahzad, Ismail Celik, Mohammad Shahid
Centella asiatica L. is a tiny succulent herb belonging to the family Apiaceae, which has several branches that root at the nodes and may be found at elevations ranging from sea level to 4400 feet. Its English name is Indian pennywort, and in the native local language, it is called Brahmi, Mandukaparni, or Gotu Kola. In traditional ayurvedic medicine, the parts of this plant such as the stem, leaves, and aerial parts are used as a brain tonic. These plant parts are also used to treat chronic diseases such as hypertension, skin diseases, urethritis, and mental disorders (Uddin et al. 2017). Centella asiatica has been reported to show antibacterial (Sieberi et al. 2020), anticonvulsant (Sudha et al. 2002), antifungal (Naz and Ahmad 2009), anti-inflammatory (George et al. 2009), antioxidant (Hamid et al. 2002), antipsoriatic (Sampson et al. 2001), antiulcer (Cheng et al. 2004), antiviral (Yoosook et al. 2000), antitumor (Bunpo et al. 2004), and insecticidal (Senthilkumar et al. 2009) activities. It is also used as a cardioprotective agent (Gnanapragasam et al. 2004) and for the treatment of venous deficiency (Pointel et al. 1987).
Asiatic acid exerts an anti-psoriatic effect in the imiquimod-induced psoriasis model in mice
Published in Immunopharmacology and Immunotoxicology, 2022
Osman Kukula, Seda Kırmızıkan, Emre Soner Tiryaki, Mustafa Nusret Çiçekli, Caner Günaydın
Imiquimod-induced psoriasis is a frequently used model to mimic psoriasis pathology in murine. Imiquimod is a toll-like receptor-7/8 agonist and is currently used to treat actinic keratosis, genital warts, and superficial basal cell carcinoma [17]. Recent studies demonstrated that imiquimod mimics psoriasis-like dermatitis by activating IL-23/IL-17 pathway [18]. Imiquimod-induced psoriasis model is accepted as the closest murine model that imitates human plaque-type psoriasis with inflammatory infiltration, redness, thickening, and skin scaling. Therefore, imiquimod is a valuable pharmacological tool to investigate compounds that might protect against psoriasis. In this study, we used the imiquimod-induced psoriasis model due to the properties mentioned above. In line with previous studies, imiquimod caused psoriasis-like dermatitis and increased serum levels of IL-17A and IL-23, which indicates its successful model development according to the previous studies [19]. However, several treatment options present in the clinics, their serious side effects and intolerance because of long-term treatment deter their use and show the urgent need for novel treatment options with fewer side effects. So, compounds derived from natural sources are accepted as ideal candidates. Therefore, we investigated the effect of asiatic acid, a well-known compound present in the Centella Asiatica. The recent works that showed wound healing and anti-inflammatory properties of Centella Asiatica and its ingredients led us to think that asiatic acid might be an effective natural compound to alleviate psoriasis pathology [20,21].