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Marine Polysaccharides in Pharmaceutical Applications
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Riyasree Paul, Sourav Kabiraj, Sreejan Manna, Sougata Jana
Mahdavinia et al. have developed κ-CG- and chitosan-based beads for oral delivery of diclofenac sodium. Incorporation of iron oxide magnetic NPs resulted in a decreased swelling ability. At pH 7.4, the maximum diclofenac sodium release was reported around 82% (Mahdavinia et al. 2015). Chitosan and chondroitin sulfate were employed to develop NPs for transdermal application of ketoprofen. The synthesized NPs were incorporated in an emulgel of argan oil. Sustained release of ketoprofen was observed up to 72 hours. A skin permeation study indicated higher permeation of ketoprofen than the marketed gel (Gul et al. 2018). Aceclofenac-loaded IPN nanocarriers were developed using glutaraldehyde cross-linked chitosan and locust bean gum. An increase in locust bean gum percentage decreased the drug entrapment. An in vitro study demonstrated restricted release of aceclofenac in acidic pH (Jana and Sen 2017). Jana et al. investigated the efficacy of chitosan-albumin based NPs for transdermal delivery of aceclofenac. The synthesized NPs were further incorporated into carbopol gel for easy topical application. The drug release study indicated sustained release pattern over 8 hours. A negative zeta potential of -22.10 mV was reported. The ex vivo skin permeation exhibited sustained penetration of aceclofenac through mice skin. Thein vivo study performed in carrageenan injected rats demonstrated higher swelling inhibition of rat paw compared to the marketed gel preparation (Jana et al. 2014).
Recent Cannabinoid Delivery Systems
Published in Betty Wedman-St Louis, Cannabis as Medicine, 2019
Natascia Bruni, Carlo Della Pepa, Simonetta Oliaro-Bosso, Daniela Gastaldi, Franco Dosio, Enrica Pessione
The application of CBD with argan oil for the treatment of the pain and swelling associated with inflammation, in arthritic and rheumatic diseases, has been described by Shemanky et al. [107]. Gel, cream, and emulsion formulations were tested.
The science of nail polish, nail polish remover, and nail moisturizers
Published in Archana Singal, Shekhar Neema, Piyush Kumar, Nail Disorders, 2019
Some polishes contain additional constituents like thickening agents to make the polish easier to apply and ultraviolet filters (benozophenone-1), which help prevent discoloration when the polish is exposed to sunlight or other forms of ultraviolet light. Some brands have added natural oils like argan oil that acts as a nail-moisturizer and makes damage less noticeable and perfumes to counteract the unpleasant odor of the solvents.7
Development, optimisation, and evaluation of nanoencapsulated diacerein emulgel for potential use in osteoarthritis
Published in Journal of Microencapsulation, 2020
Bazla Siddiqui, Asim.ur. Rehman, Ihsan-Ul Haq, Nasir M. Ahmad, Naveed Ahmed
Chondroitin sulphate (CS), a biopolymer reported with innate anti-inflammatory properties, is being prescribed in OA as a nutraceutical agent for slowing down disease progression. CS is widely distributed in the extracellular matrix, playing a major role in maintaining the metabolic activity of cartilage tissue, preventing its erosion. It also interacts with cell surface glycoprotein cluster differentiation 44 (CD44), toll-like receptor (TLR4), lectin and annexin receptors and helps in targeted delivery at the site of inflammation (Monfort et al. 2008, Aubry-Rozier 2012). Chitosan (CHS), a polycationic polymer, has been extensively investigated for its therapeutic role in OA due to its excellent biocompatible nature, increased residence time in joints and anti-inflammatory properties (Janssen et al. 2014, Adnan et al. 2020). It also enhances skin permeability by modification of skin proteins (Yin et al. 2009). CHS interacts electro statistically with CS forming nanocarriers by polyion complex formation. Argan oil obtained from Argania spinosa, being used in formulating emulgel has proven its permeation enhancing effect (Gul et al. 2018) together with anti-inflammatory and anti-rheumatic properties (EL Midaoui et al. 2016, Aydin 2017, Dakiche et al. 2017).
Development of novel pH-sensitive nanoparticles loaded hydrogel for transdermal drug delivery
Published in Drug Development and Industrial Pharmacy, 2019
Maimoona Qindeel, Naveed Ahmed, Fakhara Sabir, Samiullah Khan, Asim Ur-Rehman
Results of permeation studies concluded that significant amount of drug permeated through skin in buffer medium of pH 7.4 while very little amount of drug detected in control medium with p values of 0.001. These results can confirm that NPs permeated through skin intact otherwise the drug detection would be higher in receiving medium of pH 5.5. The reason might be that ES100 shows pH dependent dissolution behavior and insoluble at acidic pH of 5.5. The amount of drug permeated per unit area was significantly increased from 600 to 1000 µg/cm2 when argan oil was used as penetration enhancer. Main component of argan oil is oleic acid that has significant role in skin penetration through lipid fluidization hence improving penetration of NPs via paracellular pathway [33,53]. However, one important thing that should be taken into account is that as permeability was measured in mice skin that exhibit relatively higher penetration as compared to human skin. So it might be possible that permeability values can be slightly low when measured across human skin.
Protective effect of Argan oil on mitochondrial function and oxidative stress against acrylamide-induced liver and kidney injury in rats
Published in Biomarkers, 2020
Rahime Er, Birsen Aydın, Vedat Şekeroğlu, Zülal Atlı Şekeroğlu
Argan oil (AO), extracted from argan-tree (Argania spinosa) fruits, is an endemic plant of south-western Morocco. It has been used as a natural cosmetic and pharmaceutical in traditional medicine for several centuries as well as a food. AO is traditionally used for skin, nail and hair care, cooking, massaging, and healing (El Abbassi et al.2014). It displays antioxidant, anti-inflammatory, anti-malarial, anti-diabetic, anti-atherosclerotic, anti-hypercholesterolemic, anti-hypertensive, anti-proliferative and anti-carcinogenic properties (Atlı Şekeroğlu et al.2017). Previous studies suggest that AO could protect against atherosclerosis and prevent cardiovascular diseases and cancer. It has been stated that polyphenols and sterols in AO showed antiproliferative and proapoptotic effects on some cancer cell lines (El Abbassi et al.2014). It contains polyunsaturated fatty acids like oleic and linoleic acids, totopherols, sterols, phenols, triterpene alcohols, carotenoids, xanthophyls and squalene (Atlı Şekeroğlu et al.2017). Chemical analysis of AO shows that the average fatty acid content of it is mainly consist of 45% monounsaturated fatty acids (MUFA) and 35% polyunsaturated fatty acids (PUFA) (Sour et al.2015). It has been stated that AO contain antioxidants for human mitochondria such as CoQ10, melatonin and tocopherols (López et al.2013). Many in vitro or in vitro studies have also shown that AO has powerful antioxidants (Khallouki et al.2003, Necib et al.2013, El Abbassi et al.2014, Eljaoudi et al.2015, Sour et al.2015). AO is traditionally prescribed as hepatoprotective agent (El Abbassi et al.2014) and it improves oxidative stress and lipid status in haemodialysis patients (Eljaoudi et al.2015).