Analyzing the association between aortic regurgitation and atherosclerosis: is pulse pressure a cause of atherosclerosis?
Published in Clinical and Experimental Hypertension, 2018
Seijiro Shimada, Masayosi Matsuura, Takahiro Yamaguchi, Junkichi Hama
Assuming that PP is a risk factor of ASCVD, atherosclerosis should be progressive in diseases that are accompanied by increases in PP. Corrigan’s pulse, de Musset’s sign, Duroziez’s sign, Hill’s sign, Müller’s sign, Quincke’s sign, and Traube’s sign are findings observed in patients with aortic regurgitation (AR), which is inseparable from increased PP. Thus, increase in PP is a characteristic of AR. Consequently, if PP is a risk factor for ASCVD, then atherosclerosis should be progressive in AR. However, few studies have investigated the relationship between AR and atherosclerosis. Therefore, we performed a cross-sectional study of the relationship between AR and atherosclerosis using carotid intima-media thickness (IMT) and pulse wave velocity (PWV), which are regarded as excellent predictors of ASCVD (12–15).