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3D analysis of the clinical results of VISTA technique combined with connective tissue graft
Published in J. Belinha, R.M. Natal Jorge, J.C. Reis Campos, Mário A.P. Vaz, João Manuel, R.S. Tavares, Biodental Engineering V, 2019
D.S. Martins, L. Azevedo, N. Santos, T. Marques, C. Alves, A. Correia
A second surgical site is created after tunnel preparation. A free gingival graft was collected from the lateral palate, with extra-oral desepithelialization, becoming a subepithelial connective tissue graft. (Zucchelli, Mele et al. 2010).
Concentrated growth factor promotes gingival regeneration through the AKT/Wnt/β-catenin and YAP signaling pathways
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Lei Qi, Lu Liu, Yue Hu, Jie Li, Jiayi Li, Ningning Cao, Fangxing Zhu, Chaoji Shi, Lei Zhang
Patients with thin gingiva biotype often experience disappointing outcomes such as gingival recession, poor postoperative stability, and unexpected aesthetic effects during orthodontic and orthognathic treatment. Hence, the gingival graft procedure is the current “gold standard” for the treatment [1]. However, this approach has various drawbacks such as donor-site damage, limited palatal mucosal tissue, and poor postoperative outcome [2–4]. Gingival regeneration is a complex developmental process, which involves the use of growth factors to establish a fully functional vascular microenvironment for tissue survival [5]. A previous study has confirmed that concentrated growth factor (CGF), a third-generation platelet concentrate derived from autologous blood, is crucial for tissue regeneration[6]. Hitherto, the function of CGF has been rarely reported with respect to gingival regeneration.
Application of drug delivery systems for the controlled delivery of growth factors to treat nervous system injury
Published in Organogenesis, 2018
Fukai Ma, Fan Wang, Ronggang Li, Jianhong Zhu
Due to collagen possesses the characteristics of low antigenecity, excellent biocompatibility and biodegradability, collagen material has been studied in clinical trials to determine its safety and effectiveness. Xenogeneic collagen matrix from porcine was used for the generation of keratinized tissue around teeth in a single-masked, randomized, controlled, split-mouth study of 30 patients.39 The results showed that the porcine collagen matrix increased keratinized tissue around teeth to a similar degree in contrast to the positive control, an autogenous free gingival graft. The study indicated the porcine collagen matrix appeared to be a suitable substitute for autogenous free gingival graft for the patients. However, the application of collagen derived DDSs for nervous system injury repairing in patients remains to be researched in the future work.
Topical simvastatin gel as a novel therapeutic modality for palatal donor site wound healing following free gingival graft procedure
Published in Acta Odontologica Scandinavica, 2018
After harvesting the free gingival graft from the palate, the donor site was irrigated with sterile saline, and haemostasis was achieved with gauze moistened in saline. Then, four different covering techniques were applied over the donor site to protect the surgical region. In group I: Simvastatin suspension (S), group II: simvastatin/chitosan gel (SC), group III: chitosan gel (C), group IV: petroleum gel (P). In group II, the donor site was covered with simvastatin/chitosan gel (10 mg/mL). The patient was instructed to apply 1 mL of the gel or the suspension three times/day for the following 7 days post-operatively. The gel/suspension was provided in 3-mL syringes and patients were instructed to apply it over the wound using cotton swap and to avoid drinking or eating for one hour after the gel application. A non-steroidal anti-inflammatory analgesic was prescribed for the patients (twice/day). The patients recorded their analgesic consumption following the surgical procedure.