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Anatomical Criteria for the Biopsy Diagnosis of Alzheimer Disease
Published in Robert E. Becker, Ezio Giacobini, Alzheimer Disease, 2020
The Bielschowsky stain and, in the author’s experience, the von Braunmuhl stain show both these structures well, but are not easy to perform. Some immunostaining methods have been found to demonstrate only a proportion of traditionally stained NFT and SP, at least in paraffin sections, so are not suitable for obtaining a reliable estimate of their total numbers.(Connolly et al. 1987; Duykaerts et al. 1987) On the other hand, one immunoreaction, with an antibody to beta amyloid protein, shows areas of focal cortical staining in a much larger proportion of elderly brains than is affected by conventional SP and NFT formation (Davies et al. 1988). If this reaction was used indiscriminately it might be expected to overestimate the prevalence of AD. Thus, Davies et al. (1988) found cortical foci of reactivity with this antibody in nearly 80% of autopsy brains from unselected subjects at the end of the ninth decade, whereas only 19% of the same brains showed AD pathology using conventional stains.
Adansonia digitata ameliorates lead-induced memory impairments in rats by reducing glutamate concentration and oxidative stress
Published in Egyptian Journal of Basic and Applied Sciences, 2022
Eduitem S. Otong, Sunday A. Musa, Barnabas Danborno, Sohnap J. Sambo, Nathan I. Dibal
Bielschowsky stain showed normal neuronal organization and well-organized neuronal processes in the control group (Figure 3). By contrast, architectural distortion and neuronal processes degeneration were observed in Pb-treated rats (Figure 3). Mild distortion and loss of the neuronal processes were noticed in the CA1 region of AD250mg + Pb, AD500mg + Pb and DMSA + Pb-treated rats (Figure 3) when compared with the control group. Degeneration and severe neuronal loss were observed in the CA3 region of Pb, AD250mg + Pb, AD500mg + Pb and DMSA + Pb treated (Figure 3).