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Stepwise implementation of a low-cost and portable radiofrequency hyperthermia system for in vitro/in vivo cancer studies
Published in Instrumentation Science & Technology, 2021
Fatih Senturk, I. Cengiz Kocum, Goknur Guler Ozturk
All components of the radiofrequency power generator are shown in Figure S12. The radiofrequency power system generates 400 W that was monitored by a standing wave ratio (SWR) meter (Figure S12j). After implementing and testing the RF power generator and matching network, water-cooled coils were constructed with solenoid and pancake geometries. The radiofrequency power generator output was connected to a water-cooled solenoid or pancake coil to generate magnetic fields that were transmitted to the biological samples. The radiofrequency coils were manufactured from round copper tubing rather than copper wire since tubing allows the use of flowing cooling water. The impedance matching between the coil and radiofrequency generator was adjusted by tuning the matching network. While the RF-HT system was in operation, it was monitored by a thermal camera (FLIR E6, Sweden) to avoid large temperature increases (Figure S13b). A thermal image of cell culture medium (Figure S13d) was observed immediately after removing the culture flask maintained at humidified atmosphere at 37 °C and 5% CO2 from the incubator (Heraeus, Germany).