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Proteins and Proteomics
Published in Firdos Alam Khan, Biotechnology Fundamentals, 2020
Top-down proteomics is a method of protein identification that uses an ion-trapping mass spectrometer to store an isolated protein ion for mass measurement and tandem mass spectrometry analysis. The name is derived from the similar approach to DNA sequencing. Proteins are typically ionized by ESI and trapped in a Fourier transform ion cyclotron resonance (Penning trap) or quadruple ion trap (Paul trap) mass spectrometer. Fragmentation for tandem mass spectrometry is accomplished by electron capture dissociation or electron transfer dissociation.
Proteins and proteomics
Published in Firdos Alam Khan, Biotechnology Fundamentals, 2018
Top-down proteomics is a method of protein identification that uses an ion-trapping mass spectrometer to store an isolated protein ion for mass measurement and tandem mass spectrometry analysis. The name is derived from the similar approach to DNA sequencing. Proteins are typically ionized by ESI and trapped in a Fourier transform ion cyclotron resonance (Penning trap) or quadruple ion trap (Paul trap) mass spectrometer. Fragmentation for tandem mass spectrometry is accomplished by electron capture dissociation or electron transfer dissociation.
Detection Technology
Published in Rick Houghton, William Bennett, Emergency Characterization of Unknown Materials, 2020
Rick Houghton, William Bennett
An orbitrap mass analyzer is another type of cyclotron mass analyzer that uses an electrostatically charged spindle to trap ions, as opposed to the traditional Penning trap described with the Fourier transform mass analyzer. As the ions orbit the spindle, they oscillate along the spindle axis. Detector plates similar to those described with the Fourier transform mass analyzer collect information, which is processed by Fourier transformation to generate a spectrum.
Sideband cooling of small ion Coulomb crystals in a Penning trap
Published in Journal of Modern Optics, 2018
G. Stutter, P. Hrmo, V. Jarlaud, M. K. Joshi, J. F. Goodwin, R. C. Thompson
Ion Coulomb crystals (ICCs) consisting of cold, trapped atomic ions are a widely used and highly versatile experimental platform [1]. The level of control achievable with ICCs makes them a suitable choice for many applications in atomic and molecular physics, including quantum computation and simulation [2–4], cavity QED [5], atomic clocks [6] and precision measurements [7]. Penning traps use a combination of static electric and magnetic fields to confine charged particles. Such traps are often used in experiments where large magnetic fields are required, for example in quantum simulation [2], non-neutral plasma physics [8], precision measurements of masses and magnetic moments [9], and for experiments on particle beamlines (where their large, open electrode structures and large trap depths are an advantage) [10,11].
The quantum theory of the Penning trap
Published in Journal of Modern Optics, 2018
F. Crimin, B. M. Garraway, J. Verdú
Confinement of charged particles in a Penning trap is provided a static electric field and axial magnetic field . In an ideal circular Penning trap, the associated electric potential of the former provides the quadrupole