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Published in Debasis Bagchi, Manashi Bagchi, Metal Toxicology Handbook, 2020
Amit Madeshiya, Pradipta Banerjee, Suman Santra, Nandini Ghosh, Sayantani Karmakar, Debasis Bagchi, Sashwati Roy, Amitava Das
The redox inert metal zinc does not directly participate in oxidation-reduction reaction. However, in some cases, zinc acts as antioxidants. Over supplementation of iron or copper, poor dietary zinc intake, and excess dietary phytate intake cause zinc deficiency [10]. Loss of appetite, delay in wound healing, poor immune function, and dermatitis are few common symptoms of zinc deficiency [10]. Zinc has important roles in the development of immune system and also helps in maintaining insulin and blood glucose concentration. Oxidation of DNA, protein, and lipids is common due to oxidative damage during zinc deficiency. ROS formation caused by zinc deficiency is associated with lipid peroxidation in lung damage, formation of conjugated dienes and liver microsomes, lipoprotein oxidation, and galactosamine-induced hepatitis in rats [10].
Effect of Zinc Supplementation on Linear Growth Velocity of Children With Short Stature
Published in Cut Adeya Adella, Stem Cell Oncology, 2018
I.T. Pujiastuti, M. Deliana, E. Mutiara, M. Lubis
Zinc supplementation is the only effective intervention strategy for treating zinc deficiency compared to other alternatives such as fortified foods, complimentary food and diet modifications. Research in Iran in 2013 showed zinc supplementation of 5 mg for 4 months in healthy children aged 9-18 years without zinc deficiency increase linear growth rate (Kaseb & Fallah, 2013). Research in Vietnam in 1999, in children aged 6-24 months who were given zinc supplementation for 11 mg per day for 3 months, found a significant increase in body length (Nasution, 2016).
Zinc and Health
Published in Frank Porter, Zinc Handbook, 1991
Zinc is one of the 16 elements essential for crop growth. Unlike the major nutrients ordinarily supplied in mixed fertilizers, zinc is required in only infinitesimal amounts. For example, an acre of healthy oats contains only about 25-30 g of zinc. Yet without this essential quantity, no crop would grow at all. Zinc deficiency is a worldwide problem. In acute form, zinc deficiency causes easily recognizable diseases in crops − for example, white bud of corn, little leaf of apple or pear, rosette of pecans or mottle leaf of citrus. Yields are low, seeds do not form and the crops may be a total failure. Deficiency of zinc and other micronutrients is increasing because of increased use of chemical fertilizers, the rise in crop yields, increased cultivation of marginal land and decreased use of animal manures. High levels of phosphate often induce zinc deficiency in corn, beans and other important crops. Superphosphates used to contain as much as 5000ppm(0.5%) zinc, because they were manufactured from zinc-contaminated sulphuric acid. Today, many phosphates for fertilizers are high purity and contain little or no zinc. Nitrogen compounds and potash, also incorporated into fertilizers, are also mostly in purified form.
Synthesis, characterization, X-ray structural analysis, DFT and BSA binding study of a Zn(II) complex, [Zn(II)Cl2(nia)2].2nia
Published in Journal of Coordination Chemistry, 2021
Anju Saini, Raj Pal Sharma, Parmjeet Kaur, Priti Bansal, Bal Krishan, Paramjeet Kaur, Valeria Ferretti, Pankaj Kandwal
Zinc is the second most abundant trace element in the human body and plays an important role in a large number of enzymatic reactions [6]. It is found that Zn is an important component of more than 300 metalloenzymes as it enhances their catalytic, structural and regulatory activities [6]. Zinc is non-toxic and flexible to form stable coordination complexes with macromolecules to carry out diverse biological functions. Zinc deficiency can cause growth effects and disorders of the central nervous system. Zinc(II) complexes have gained immense importance due to potential applications such as antidiabetic, insulin-mimetics, antiinflammatory, antimicrobial, antiproliferative, aiding as tumor photosensitizers, treatment of Alzheimer's disease, radioprotective, antibacterial, anticancer and antidandruff agents [7–11]. In Asian and African countries “Baby Zinc” has been extensively used for the treatment of deadly diarrhoea [9]. 17β-Hydroxylsteroid dehydrogenase (17BHSD) requires not only zinc but also sufficient niacin-based co-enzyme to become completely functional [12].
Transition metal complexes of novel binuclear Schiff base derived from 3,3′-diaminobenzidine: synthesis, characterization, thermal behavior, DFT, antimicrobial and molecular docking studies
Published in Journal of Coordination Chemistry, 2020
Venkittapuram Palaniswamy Radha, Subramanian Chitra, Suyambulingam Jonekirubavathi, Ill-Min Chung, Seung-Hyun Kim, Mayakrishnan Prabakaran
The azomethine linkage of Schiff bases is responsible for the biological activities such as treatment of cancer [11], as antibacterial [12], antiviral agent [13, 14], and other biological properties [15]. These complexes have several applications in absorption, chemical analysis, heterogeneous, and homogeneous catalysis, in pesticides, for oxidation and polymerization of organic compounds [16–18]. In recent years, nonplatinum-based metal therapeutics, in particular late 3d transition metal ions viz. Co(II), Ni(II), Cu(II), and Zn(II), are endogenously compatible to the living systems [19]. Those Schiff bases which form binuclear transition metal complexes are useful in studying the relation between structures and magnetic exchange interaction and to mimic bimetallic biosites in various proteins and enzymes [20, 21]. Copper is a biologically relevant element and many enzymes that depend on copper for their activity have been identified. Zinc is essential to all forms of life and a large number of diseases and congential disorders have been traced to zinc deficiency. Zinc is a natural component of insulin and it controls sugar metabolism. In this regard, there is a great interest in binucleating Schiff base ligands and their transition metal complexes.
“Our turn to eat:” Shifting gender norms and food security in the Wakiso district of Uganda
Published in Journal of Hunger & Environmental Nutrition, 2019
Amialya E. Durairaj, Constance A. Gewa, Maction K. Komwa, Lisa Pawloski
Ugandan females are at a higher risk of developing iron, vitamin A, and zinc deficiencies.2 Approximately 23% of the reproductive age women are anemic.3 An additional 36% of reproductive age women are vitamin A deficient.3 The prevalence of zinc deficiency is 20%–30% in adults.4