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Medicinal Mushrooms
Published in Anil K. Sharma, Raj K. Keservani, Surya Prakash Gautam, Herbal Product Development, 2020
Temitope A. Oyedepo, Adetoun E. Morakinyo
The antioxidant activity of edible mushrooms could be directly applied to daily life because it is associated with natural prevention of oxidative stress which is often as a result of lifestyle habits (Sakano et al., 2009). A number of in vitro and in vivo studies have reported antioxidant potentials of various mushroom species that enable them to neutralize free radicals (Ferreira et al., 2009). Assays involving chromogen compounds (e.g., ABTS and DPPH methods) are the most commonly used methods to measure mushrooms antioxidant activity (Sánchez, 2016). The findings of those studies demonstrated that the antioxidant components are found in fruit bodies, mycelium and culture both of the mushrooms. These often show good activity as a scavenger of DPPH radical and reactive oxygen species (hydroxyl radical, superoxide radical, and hypochlorous acid). They also act as an xanthine oxidase inhibitor which has indications for various therapeutic procedures, including cancer therapy since inhibition of Xanthine Oxidase can inhibit the oxidation of 6-mercaptopurine and potentiate antitumor properties (Pacher et al., 2006; Ribeiro et al., 2007). The metabolites responsible for the antioxidant activities include polysaccharides, phenolic compounds, carotenoids, ergosterol, tocopherols, ascorbic acid and many others (Sánchez, 2016; Zhang et al., 2016a).
Heterometallic Cu(II)-M(II) (M = Mg, Ca and Sr) complexes with a N,O-donor ligand in situ generated from topiroxostat
Published in Journal of Coordination Chemistry, 2020
Xiang Chang, Li-Ting Jiang, Sheng-Chun Chen, Ming-Yang He, Qun Chen
Families of active pharmaceutical ingredients (APIs) are promising building blocks for the construction of functional solids, including metal complexes [12] and organic cocrystals [13], because of their rich coordination modes and multiple hydrogen-bonding sites as well as modified physical and biological properties. For instance, a variety of coordination polymers have been prepared from the API-based organic ligands, such as the anti-inflammatory drug olsalazine [14], the antibiotics of nalidixic acid [15], sarafloxacin [16], letrozole [17], pipemidic acid [18], fluconazole [19], and norfloxacin [20]. In our previous work, we employed the selective xanthine oxidase inhibitor topiroxostat to build two discrete copper(II) complexes [21]. However, coordination polymers with topiroxostat ligand have not been reported so far. Therefore, it is a challenge to construct infinite coordination networks derived from topiroxostat.