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Therapeutic Nanostructures for Improved Wound Healing
Published in Bhaskar Mazumder, Subhabrata Ray, Paulami Pal, Yashwant Pathak, Nanotechnology, 2019
Lalduhsanga Pachuau, Pranab Jyoti Das, Bhaskar Mazumder
Seed oil from Nigella sativa, a black cumin, has been used traditionally as a therapy for several diseases and ailments. An active constituent from the plant, thymoquinone, has been reported to possess an antioxidant property through powerful radical scavenging activity (Guler et al., 2014). When N. sativa emulsion without any enrichment was equated against the N. sativa oil enriched with Calendula officinalis extract and lipoic acid-capped gold nanoparticles (AuNP–LA) through nanoemulsification, improved antioxidant and wound healing properties were observed.
In vitro studies to analyze the stability and bioavailability of thymoquinone encapsulated in the developed nanocarrier
Published in Journal of Dispersion Science and Technology, 2020
Vignesh Kumar S, Renuka Devi P, Hemananthan E
In the past few decades, research in the use of thymoquinone as a pharmaceutical or nutraceutical agent is gaining lot of importance in pharmaceutical and food formulations.[1] Thymoquinone - a natural antioxidant extracted and purified from the black seed of the plant Nigella sativa L. has been identified to cure many inflammatory disorders with its antioxidant, anti-inflammatory, anti-infective, neuroprotective, antiviral and anti-carcinogenic properties.[2] The efficacy of Nigella sativa seed extract to suppress coughs, disintegrate renal calculi, impede the carcinogenic process, treat abdominal pain, diarrhea, flatulence and polio was acknowledged to thymoquinone, being the primary constituent of the seeds.[3,4] Apart from Nigella sativa L. seeds, thymoquinone was identified in plants such as Callitris quadrivalvis, Monarda fistulosa, Juniperus cedrus, Tetraclinis articulata and Nepeta leucophylla relatively in a lower amount.[5] The anti-inflammatory property of thymoquinone was by the inhibition of cyclooxygenase and 5-lipoxygenase pathways of arachidonate metabolism. In case of tumors, thymoquinone reduced glutathione levels in a dose-dependent manner and induced reactive oxygen species generation.[6] Poor stability and bioavailability of thymoquinone serves as a barrier for translating it to therapeutic or nutraceutical applications. Hence it is essential to formulate a new carrier to improve its stability and bioavailability.
Antibacterial electrospun nanomat from nigella/PVA system embedded with silver
Published in The Journal of The Textile Institute, 2021
Ayub Ali, Syed Maminul Islam, Md. Mohebbullah, Md. Nur Uddin, Md. Tofazzal Hossain, Sonjit Kumar Saha, Mohammad Salman Ibna Jamal
As the particle diameter decreased, the particle specific surface increased, conducive to the adsorption of bacteria and action with the thiol to kill the bacteria. Besides, the presence of Thymoquinone (TQ) and Thymohydroquinone (THQ) constituents from nigella seeds also contributed to the formation of inhibition zone (Forouzanfar et al., 2014). This indicates that, there was a synergistic antibacterial affect which comes from nigella extract and silver nanoparticles. Besides, the mesho structures of the developed nanomat can prevent the penetration of any bacteria due to the presence of tiny pores and hence preclude the surrounding infections effectively (Unnithan et al., 2012).