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Nanostructures for Improving the Oral Bioavailability of Herbal Medicines
Published in Bhaskar Mazumder, Subhabrata Ray, Paulami Pal, Yashwant Pathak, Nanotechnology, 2019
Nanodispersion of taxifolin dihydrate, a naturally occurring flavonoid, prepared by co-precipitation-lyophilization resulted in the aggregation of free spherical particles with a mean size of about 150 nm and the prepared dispersion significantly enhanced the dissolution of taxifolin as a 90% taxifolin release was observed within the first 30 minutes (Shikov et al., 2009). The oral bioavailability of naringenin, a bioactive flavonoid, was also reported to be significantly enhanced after formulation into nanocrystals by the supercritical antisolvent method (Zhang et al., 2013). Compared to the coarse naringenin powder, the nanocrystal formulation exhibited a significantly decreased Tmax, with a 3.6-fold higher Cmax and 3.4-fold higher AUC.
Exploring the Hidden Ethnobotanical Treasures for Treating or Managing Chronic Alcoholism
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Natural Products Pharmacology and Phytochemicals for Health Care, 2021
Sameer A. Hedaoo, Debarshi Kar Mahapatra
Chemical constituents: The plant contains at least seven flavolignans and the flavonoid taxifolin. The most important flavolignans present include silybin, silydianin, and silychristine. Silybin represents between 50% and 70% of the extract from silymarin.
Phenolic compounds and antioxidants from Eucalyptus camaldulensis as affected by some extraction conditions, a preparative optimization for GC-MS analysis
Published in Preparative Biochemistry & Biotechnology, 2019
Alyaa Nasr, Tehmina Saleem Khan, Guo-Ping Zhu
Although the maximum values of phenolics and tannins were ascribed to the leaf and bud extracts; the plant seed of E. camaldulensis showed appreciable contents of phenolics with corresponding antioxidant activities. Regardless of the solvent concentration; the highest averaged values of phenolic compounds and H2O2 scavenging were recorded for the seed, which also came the second after the plant leaf, with a comparable amount of tannins. Also, the GC-MS analysis revealed that seed recorded the highest relative abundances of most detected phenolic compounds including gallic acid. El-Ghorab et al.[70] showed that gallic acid and ellagic acid were considered as the main antioxidant compounds in the leaf-ethanolic extract of E. camaldulensis with substantial antioxidant activities, however, the plant seed was not investigated in their study. Tricetin and taxifolin were highly detectable in the four organs of E. camaldulensis; triticin was reported to maintain anticancer properties on human breast adeno-carcinoma MCF-7 cells,[79] while taxifolin has been shown to inhibit the ovarian cancer cell growth in a dose-dependent manner.[80]