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Greener Synthesis of Potential Drugs
Published in Ahindra Nag, Greener Synthesis of Organic Compounds, Drugs and Natural Products, 2022
Renata Studzińska, Renata Kołodziejska, Daria Kupczyk
Benzofuran is considered a very important oxygen-containing heterocyclic compound due to its diverse biological profile. Many of the clinically approved medicines are synthetic and naturally occurring substituted benzofuran derivatives, which display various biological activities including antitumor, antiarrhytmic, antidepressant, antihyperglycemic, antimicrobial, antibiotic, antiparasitic [161].
New multi-fluorinated benzofuran liquid crystals with large dielectric anisotropy and improved solubility
Published in Liquid Crystals, 2022
Jian Li, Lingchao Mo, Zhaoyi Che, Juanli Li, Minggang Hu, Danyang Wan, Zhongwei An
The reference compounds with 5,6-difluoro-benzofuran ring (1 r~4 r) give dielectric anisotropies of 14.1~17.6. Further fluorination of the benzene ring leads to a significant increase in dielectric anisotropy, and the dielectric anisotropies of compounds with tetrafluoro substituents reach 21.7~30.9. According to our knowledge, the dielectric anisotropy of conventional tetrafluoro liquid crystals based on benzene or cyclohexane ring is usually less than 20, for example, the dielectric anisotropy of terphenyl 15 is 19.5. As shown in Figure 7, the dielectric anisotropies of tetrafluoro benzofuran liquid crystals designed in this paper are much larger than that of conventional liquid crystals. These compounds have relatively large birefringence, and the birefringence of biphenyl substituted benzofuran compound 5 even reaches to 0.34.
5,6-Difluorobenzofuran: a new core for the design of liquid crystal compound with large dielectric anisotropy and broad nematic range
Published in Liquid Crystals, 2021
Jian Li, Zhaoyi Che, Lingchao Mo, Xiaozhe Yang, Minggang Hu, Zhongwei An, Aiai Gao, Weisong Du, Deng Deng
For phenyl-substituted benzofuran compounds (1, 2), no mesomorphic phase was found during the heating process and smectic B phase appears during the cooling process. While for cyclohexylphenyl-substituted benzofuran compounds (3, 4) and bicyclohexyl-substituted benzofuran compounds (5, 6), it was found that nematic phase appears during both heating and cooling process. The melting points of bicyclohexyl-substituted benzofuran compounds are lower than that of the corresponding cyclohexylphenyl-substituted benzofuran compounds, and the nematic ranges are broader.