Solid-phase synthesis

Solid-phase synthesis is a method of chemical synthesis where the starting material, synthetic intermediates, and products are attached to an insoluble material, known as the support. This allows for easy physical separation of intermediates from solvents and reactants. In essence, solid-phase synthesis involves synthesizing molecules on a solid support.From: Chemistry of Peptide Synthesis [2019], Solid-phase synthesis of sulfur containing heterocycles [2018]

Combinatorial Chemistry Approach and the Taguchi Method for Phosphors

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Published in Ru-Shi Liu, Xiao-Jun Wang, Phosphor Handbook, 2022

Lei Chen, Chen Gao

The origin of combinatorial chemistry could date back to 1963, when a biochemist from Rockefeller University named Robert Bruce Merrifield developed the portioning-mixing (also named split-mix) solid-phase synthesis method for multicomponent peptides [4]. Currently, the technique of solid-phase synthesis, invented by Merrifield, has become a standard method for the synthesis of peptides and nucleotides. Consequently, Robert Bruce Merrifield has been awarded with the Nobel Prize in Chemistry in 1984 for his invention of solid-phase peptide synthesis [5].

Solid-phase synthesis of sulfur containing heterocycles

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Published in Journal of Sulfur Chemistry, 2018

Navjeet Kaur

In solid-phase synthesis, the starting material, synthetic intermediates, and products are linked to an insoluble material (the support) which enabled the simple physical separation of intermediates from solvents and reactants. The main requirement of solid-phase chemistry is a linker which is used to attach a substrate molecule to the solid phase. After the completion of reaction, the product was isolated by cleavage of the linker. The main features of solid-phase synthesis are: (i) attachment of building block to a matrix, which can be filtered, (ii) repeated cycles of chemical conversions (coupling and de-protection) are conducted, also by automation, and (iii) mostly the final product is released from the matrix. But the final product can also be de-protected while it is attached to support by proper choice of chemistry [21].

Solid-phase synthesis

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Combinatorial Chemistry Approach and the Taguchi Method for Phosphors

Solid-phase synthesis of sulfur containing heterocycles