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Clinical Effects of Pollution
Published in William J. Rea, Kalpana D. Patel, Reversibility of Chronic Disease and Hypersensitivity, Volume 5, 2017
William J. Rea, Kalpana D. Patel
Celiac disease is associated with lifelong risk of any malignancy between 8.1% and 13.3% with the risk for non-Hodgkin's lymphoma alone being 4.3%–9%.1142,1143 This risk is 19-fold higher than the risk in the general population. Selenium deficiency in association with celiac disease may be a significant factor in the increased cancer risk. Selenium deficiency is associated with increased risk to several cancers, and selenium supplements are beneficial in reducing the incidence of liver cancer and decreasing mortality in colorectal, lung, and prostate cancer.1144,1145
Selenium speciation in cereals by ultrasonic-assisted enzyme extraction and HPLC-ICP-MS
Published in Gary Bañuelos, Zhi-Qing Lin, Dongli Liang, Xue-bin Yin, Selenium Research for Environment and Human Health: Perspectives, Technologies and Advancements, 2019
S.Z. Chen, L.P. Liu, Y. Liu, T.H. Zhou
Selenium (Se) is one of the essential trace elements in human body, with a very narrow concentration range from sufficient to deficient or toxic (Olmedo et al. 2013, Sun et al. 2013). Selenium deficiency can lead to anemia, coronary heart disease, Kashin-beck disease, diabetes, and more than 40 other diseases (Rayman 2000). High levels of Se can, however, also cause chronic toxic symptoms, such as cirrhosis, liver cancer, tooth, hair and nail loss, eye irritation, and paralysis (Bem 1981, Najafi et al. 2012).
Insights into the mechanisms of arsenic-selenium interactions and the associated toxicity in plants, animals, and humans: A critical review
Published in Critical Reviews in Environmental Science and Technology, 2021
Waqar Ali, Hua Zhang, Muhammad Junaid, Kang Mao, Nan Xu, Chuanyu Chang, Atta Rasool, Muhammad Wajahat Aslam, Jamshed Ali, Zhugen Yang
Approximately 0.5 to 1 billion people worldwide suffer from Se deficiency (Jones et al., 2017), which makes them prone to several diseases, such as white muscle and Keshan disease (Shahid et al., 2018). Selenium deficiency occurs in humans when Se intake is <40 µg/d (Navarro-Alarcon & Cabrera-Vique, 2008; Winkel et al., 2011), which can cause reduced bone metabolism, growth obstruction, irregularities in thyroid function, reduced fertility, a weakened immune system, and even induce cancer (Chang et al., 2019; Gupta & Gupta, 2017; Navarro-Alarcon & Cabrera-Vique, 2008). Inorganic Se is 40 times more toxic than organic Se (Vinceti, Maraldi, Bergomi, & Malagoli, 2009). However, an intake of Se that is >400 µg/d (Winkel et al., 2011) can lead to severe toxicological effects in humans, such as skin lesions, nail and hair loss, cancer, nervous disorders, amyotrophic lateral sclerosis, diabetes, and paralytic symptoms (Chauhan et al., 2019; Fordyce, 2013).
Understanding selenium metabolism in plants and its role as a beneficial element
Published in Critical Reviews in Environmental Science and Technology, 2019
Reshu Chauhan, Surabhi Awasthi, Sudhakar Srivastava, Sanjay Dwivedi, Elizabeth A. H. Pilon-Smits, Om P. Dhankher, Rudra D. Tripathi
An insufficient intake of Se is linked to several diseases in humans like Keshan Disease and white muscle disease (Fordyce, 2013; Shi et al., 2017). Selenium deficiency in humans also makes them prone to several health risks, such as myxedematous endemic cretinism, growth retardation, impaired bone metabolism, abnormalities in thyroid function, reduced fertility and immune function, which can lead to cancers (Lobanov et al., 2009; Feng, Wei, & Tu, 2013; Gupta & Gupta, 2016). The recommended dose of Se is 50–55 µg/d by WHO and 50–70 μg/d by USDA (WHO, 2009; USDA, 2012). In humans, Se deficiency occurs when Se intake is below 40 µg/d (Winkel et al., 2011). Recently, Jones et al. (2017) reported that about 0.5 to 1 billion people are suffering from Se deficiency worldwide. On the other hand, higher dose exposure of Se can lead to adverse health problems, such as skin lesions, hair and nail loss, nervous disorders including paralytic symptoms and death (Fordyce, 2013). Inorganic Se is about 40 times more toxic than organic Se (Vinceti et al., 2013). High levels of Se (>400 µg/d) are toxic to humans (Winkel et al., 2011). The European Food Safety Authority (Scientific Committee on Food, 2006) guidelines have set the tolerable upper intake limit of Se to300 μg/d for adults, 60 µg/d for children aged 1 to 3 years and 250 µg/d for children aged 15 to 17 years.
Selenate and Selenite Induced Differential Morphophysiological Modifications to Mitigate Arsenic Toxicity and Uptake by Wheat
Published in Soil and Sediment Contamination: An International Journal, 2023
Sana Ullah, Nizamuddin Depar, Dawood Khan, Ayaz Ali Memon, Amanat Ali, Asif Naeem
On the other hand, Se is an essential and vital micronutrient for animals and human as well. The beneficial role of Se in plants is especially recognized under stress environment (Sarwar et al. 2020). The recommended dietary intake of Se for human is 55 µg day−1 and its deficiency is affecting about 1 billion people around the globe (Ali et al. 2021; Jones et al. 2017; Wang et al. 2021). Selenium deficiency resulted in male infertility, weakens immune system, cardiac diseases, inflammatory disorders, diabetes, and cancer development (Sarwar et al. 2020; Sattar 2021). In Egypt and China more than 40% diseases are related to Se deficiency in diet (Feng et al. 2021).