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Extraction, Isolation and Utilisation of Bioactive Compounds from Waste Generated by the Olive Oil Industry
Published in Quan V. Vuong, Utilisation of Bioactive Compounds from Agricultural and Food Waste, 2017
J. Lozano-Sánchez, I. Cea Pavez, E. González-Cáceres, H. Núñez Kalasic, P. Robert Canales, A. Segura Carretero
In a recent study, the potential use of the combination of super/subcritical fluids to produce extracts enriched in oleuropein from olive leaves was tested. The phenolic compounds from olive leaves were extracted with PLE and SFE. The effect of the techniques was studied upon the yield, oleuropein content and scavenging radical activity. The serial combination of SFE-CO2 modified by 5 per cent ethanol and subcritical water afforded high extract yield (44.1 per cent), high recovery of oleuropein (4.6 per cent) and good antioxidant activity. It was suggested that the removal of non-polar compounds with SFE-CO2 resulted in enrichment of the residue of oleuropein, which was then extracted with PLE by subcritical water (Xynos et al. 2012). Table 4 summarizes the extraction methods applied to different olive byproducts.
Oleuropein attenuates the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-perturbing effects on pancreatic β-cells
Published in Journal of Environmental Science and Health, Part A, 2021
Eun Mi Choi, Kwang Sik Suh, Soo Jin Yun, Jinsun Park, So Young Park, Sang Ouk Chin, Suk Chon
Oleuropein is a phenolic compound that is mainly found in olive leaves and fruits. This compound exhibits many pharmacologic and biological benefits and is primarily responsible for the antioxidant properties.[10,11] Oleuropein has anti-diabetic functions such as reducing serum glucose level and attenuated impaired glucose tolerance in diabetic rodent models.[12,13] Supplementation with olive leaf extract containing oleuropein improved insulin sensitivity and pancreatic beta cell secretory capacity in overweight middle-aged men.[14] However, the effects and mechanisms of action associated with pharmacological application of oleuropein for treatment of TCDD-induced toxicity remain to be elucidated. In view of the above considerations, the aim of the present research was to investigate the protective effects of oleuropein against TCDD toxicity in the pancreatic beta-cell line.
Special designed deep eutectic solvents for the recovery of high added-value products from olive leaf: a sustainable environment for bioactive materials
Published in Preparative Biochemistry & Biotechnology, 2021
Selin Şahin, Ebru Kurtulbaş, Mehmet Bilgin
Olive tree is one of the oldest cultivated trees in the world. In fact, it was mentioned in the holy books of the three great religions as a symbol of fertility, peace, reason, longevity and maturity. Its use dates back to ancient times, when the winners of the Olympic Games were crowned with olive leaves.[1] It has been a symbol of peace, salvation and abundance for centuries. The olive branch is officially the symbol of peace in the United Nations.[2] On the other hand, olive and its by-products have been transferred from generation to generation as traditional medicines in Spain, Italy, France, Greece, Israel, Algeria, Tunisia, Turkey and Mediterranean islands.[3] Pharmacologically, its most effective by-product is olive leaf.[4] Olive leaf extract has been suggested as natural additive for drug and cosmetic industries due to its phythochemical content which shows antioxidative, antimicrobial, antiinflammatory, anticancer, antiatherogenic, and hypoglycemic properties.[5–7] Due to its huge health benefits, it has been studied thoroughly.[8] Supercritical fluid extraction method has been studied by using supercitical CO2 modified by ethanol, methanol and water.[9.10] Şahin and Samli (2013) used ultrasound for the polyphenols extraction by means of ethanol-water solution.[11] As a green approach, solvent-free microwave technology have been also reported for the extraction of olive leaf extract rich in oleuropein.[12]
Biosynthesis, characterization and antioxidant activity of oleuropein-mediated silver nanoparticles
Published in Inorganic and Nano-Metal Chemistry, 2020
Nusret Genc, Ilyas Yildiz, Radia Chaoui, Ramazan Erenler, Cengiz Temiz, Mahfuz Elmastas
Plants have been used extensively from ancient times due to their significant bioactive contents.[6–12] The olive tree known as Olea europaea L. belongs to the Oleaceae family, is native to warm temperature regions of the world. Olive leaves have been employed for their medicinal properties for years. Olive oil has a preventive effect and it significantly declines the risk of cancer. In addition, consumption of olive oil decreases the considerable the risk of developing breast cancer as well as digestive system cancer.[13] The olive oil contains phenolic acids and derivatives, phenolic alcohols, secoiridoids, lignans, and flavonoids.[14] Oleuropein is found in olive leaves as a major product.[15] Oleuropein is an ester of hydroxytyrosol including an oleosidic skeleton and a carbohydrate group. Oleuropein has been reported to have antioxidant, anticancer, anti-inflammatory, cardioprotective, cardioprotective, hepatoprotective effects.[15–17] Paramagnetic nano-oleuropein was synthesized and it revealed the inhibition of AGS cancer cells.[18] Although the antibacterial activity of the olive leaves-mediated silver nanoparticles was investigated,[19] there was not any study on silver nanoparticles using oleuropein as a natural product isolated from olive leaves. Herein, silver nanoparticles using oleuropein were synthesized, characterized and their antioxidant activity was investigated.