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Screening and Pharmacological Management of Neuropathic Pain
Published in Suvardhan Kanchi, Rajasekhar Chokkareddy, Mashallah Rezakazemi, Smart Nanodevices for Point-of-Care Applications, 2022
Manu Sharma, Ranju Soni, Kakarla Raghava Reddy, Veera Sadhu, Raghavendra V. Kulkarni
Tricyclic antidepressant (TCA) drugs have shown sufficient therapeutic potential in relieving pain due to diabetic, postherpetic, and trigeminal neuralgia. Their ability to induce analgesia depends upon blockage of noradrenaline and serotonin reuptake and blockage of N-methyl-D-aspartate agonists and sodium channels [29]. Drugs like amitriptyline, venlafaxine, duloxetine, and imipramine show simultaneous inhibition of the reuptake of noradrenaline and serotonin whereas desipramine and nortriptyline are selective inhibitors of noradrenaline uptake. Continuous use of TCA is usually associated with dry mouth, constipation, nausea, vomiting, and dizziness but is of low clinical significance at doses used in neuropathic pain management [30].
Polymer-mediated electrospun nanofibrous mats on supramolecular assembly of nortriptyline in the β-cyclodextrin medium for antibacterial study
Published in Journal of Biomaterials Science, Polymer Edition, 2022
Rajaram Rajamohan, Angaiah Subramania, Yong Rok Lee
Nortriptyline, 3-(10, 11-dihydro-5H-dibenzo [a,d] cyclohepten-5-ylidene)-N-methyl-1-propanamine, is a tricyclic antidepressant drug widely used in the treatment of unipolar depression since it is a nonselective serotonin uptake inhibitor [11]. Literature survey reveals that nortriptyline is official in British Pharmacopeia [12]. One decade back, conductivity measurements have been carried out successfully to study the behavior of some selective tricyclic antidepressant drugs (TCAs), imipramine, desipramine, and amitriptyline hydrochlorides in the presence of β-cyclodextrin at 25 °C. The TCAs have been found to show an aggregation behavior in an aqueous solution. In the presence of β-CD, the TCAs form inclusion complexes with a 1:1 stoichiometric ratio [13]. To the best of our familiarity, there are no previous reports on the supramolecular assembly on the NFM moiety for the antibacterial activity. In recent years, the cyclodextrin oriented supramolecular assembly with tricyclic antidepressants like amitriptyline, nortriptyline, protriptyline, maprotiline, imipramine, chlori-pramine, doxepin-E, and doxepin-Z has been studied with the help of HPLC and powder XRD [14–17]. Supramolecular assembly between a guest and host like antidepressants has been a great interest for further applications such as drug delivery [18], and antibacterial activities. In recent years, there has been a growing interest in researching and developing new antimicrobial agents from various sources to combat microbial resistance. In all areas of the environment, especially in food packaging, they are essential. Microbial resistance within the packaging industry must be a major concern. Increase the production and availability of the material that readily controls microbial growth in food production, as well as its preservation in terms of packaging. Therefore, greater attention has been paid to the screening and evaluating methods of antimicrobial activity.