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List of Chemical Substances
Published in T.S.S. Dikshith, and Safety, 2016
n-Butylamine is one of the four isomeric amines of butane, the others being sec-butyl-amine, tert-butylamine, and isobutylamine. It is a highly flammable, colorless to yellow liquid. It is stable and/but incompatible with oxidizing agents, aluminium, copper, copper alloys, and acids. n-Butylamine is used in the manufacture of pesticides (such as thiocar-bazides), pharmaceuticals, and emulsifiers. It is also a precursor for the manufacture of N,N’-dibutylthiourea, a rubber vulcanization accelerator, and n-butylbenzenesulfonamide, a plasticizer of nylon.
Guanidine based copper(II) complexes: synthesis, structural elucidation, and biological evaluation
Published in Inorganic and Nano-Metal Chemistry, 2022
Muhammad Said, Hizbullah Khan, Ghulam Murtaza, Muhammad Sirajuddin, Amin Badshah, Syed Muhammad Salman, Rukhsana Gul
Organic solvents, chemicals and reagents were purchased from E. Merck, Fluka and Sigma-Aldrich. Copper(II) acetate, potassium thiocyanate, mercury(II) chloride, thionyl chloride, benzoic acid, copper(II) chloride, magnesium sulfate, 2,6-dichloroaniline, DMF, chloroform, methanol, n-hexane and p-toludine were processed without foster refinement. Triethylamine, dibutylamine, sec- butylamine, n-butylamine, isobutylamine, tert-butylamine, propylamine and isopropylamine were purified through distillation. In addition, the solvents such as alcohols, chloroform, acetone, n-hexane, dichloromethane and petroleum ether were first distilled, purified, and dried in an established manner. Finally their saturation with nitrogen, storage over molecular sieves of 4 Å and degassing was achieved.[36]
Synthesis, characterization, crystal structure, and antimicrobial studies of novel thiourea derivative ligands and their platinum complexes
Published in Journal of Coordination Chemistry, 2018
Ummuhan Solmaz, Ilkay Gumus, Gun Binzet, Omer Celik, Gulten Kavak Balci, Aylin Dogen, Hakan Arslan
Ligands were synthesized in two steps. In the first step, 4-chlorobenzoyl isothiocyanate was synthesized by reaction of 4-chlorobenzoyl chloride with an equimolar amount of potassium thiocyanate in dry acetone. In the second step, ligands (HL1–4) were obtained from reaction of 4-chlorobenzoyl isothiocyanate with a secondary amine (diethylamine, di-n-propylamine, di-n-butylamine, and diphenylamine) in dry acetone. Scheme 1 outlines the synthesis of the series of thiourea derivatives. The ligands were purified by recrystallization from an ethanol:dichloromethane mixture and characterized by elemental analysis, 1H NMR, 13C NMR and FT-IR techniques. Data of all synthesized compounds confirm the proposed structures (Figures S1, S3, S7, S9, S11, S15, S17, S19, S23, Supporting Information). The reaction of the ligands with potassium tetrachloroplatinate(II) at room temperature with an ethanol:water mixture as solvent yielded the four new complexes cis-[Pt(L1–4-S,O)2] (Scheme 2). All the new metal complexes were recrystallized from an ethanol:dichloromethane mixture and characterized by elemental analysis, 1H NMR, 13C NMR, cozy, HMQC, and FT-IR techniques (Figures S2, S4, S5, 6S, S8, S10, S12, S13, S14, S16, S18, S20, S21, S22, and S24, Supporting Information). The proposed structures given in Schemes 1 and 2 are consistent with the analytical and spectroscopic data.
New binuclear dithiocarbamate complexes [M2-µ2-bis-{(κ2S,S-S2CN(R)CH2CONHC6H4)2CH2}] (M=NiII, CuII, and ZnII): synthesis, characterization, DFT, and in vitro cytotoxic study
Published in Journal of Coordination Chemistry, 2018
Vinay K. Singh, Vineeta Pillai, Prakash Gohil, Shailykumari K. Patel, Lipi Buch
An excess amount of cyclohexyl amine (892.2 mg, 9 mmol), isopropylamine (531.9 mg, 9 mmol) or n-butylamine (658.2 mg, 9 mmol) was added to an ethanolic solution of 4,4’-bis(2-chloroacetamido)diphenylmethane (702.4 mg, 2 mmol). The reaction mixture was refluxed in the presence of catalytic amount of Et3N for 8 h and the progress was examined by TLC. The reaction mixture was cooled to room temperature and further poured on ice; precipitates obtained were filtered and washed with cold water, followed by n-hexane and diethyl ether to produce diamines L1–L3 in good yields. These samples were stored under a N2 atmosphere and further taken for analysis. The overall reaction is presented in Scheme 1.